Neuroimaging-Based Brain and Spinal Cord Biomarkers for Cervical Radiculopathy

基于神经影像的脑和脊髓颈神经根病生物标志物

• 批准号: 10472715
• 负责人: Kenneth Arnold Weber
• 金额: $ 17.4万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10472715
• 关键词: Acute Pain; Address; Affect; Age; American; Area; Attention; Award; Base of the Brain; Biological Markers; Brain; Brain Stem; Brain imaging; Cell Nucleus; Cervical Radiculopathies; Cervical nerves; Cervical spinal cord structure; Clinical; Clinical Management; Clinical Research; Computing Methodologies; Data Analyses; Development; Disease; Etiology; Faculty; Failure; Functional disorder; Funding; Goals; Grant; Healthcare Systems; Household; Image; Individual; Investigation; K-Series Research Career Programs; Knowledge; Lead; Left; Link; Magnetic Resonance; Maintenance; Measures; Medical Imaging; Mentors; Methods; Modeling; Motor; Musculoskeletal Pain; Neck; Neuraxis; Neurobiology; Neuronal Plasticity; Neurosciences; Pain; Pain Research; Pain intensity; Pathology; Patient imaging; Patients; Pattern; Peripheral; Plant Roots; Positioning Attribute; Prevalence; Process; Prognostic Factor; Public Health; Randomized Controlled Trials; Recovery; Research; Research Personnel; Research Training; Rest; Role; Sampling; Sensory; Severities; Side; Spinal Cord; Structure; Synaptic Transmission; Techniques; Thalamic structure; Training; Upper Extremity; Work; Writing; base; career development; chronic pain; chronic pain management; chronic pain patient; chronic painful condition; clinical pain; cohort; design; diffusion weighted; disability; falls; improved; in vivo; individualized medicine; innovation; irritation; machine learning prediction; multidisciplinary; neural network; neuroimaging; neurotransmission; novel; pain chronification; pain model; pain reduction; patient oriented research; programs; recruit; relating to nervous system; sex; skills; spinal cord imaging; statistical learning; success; tenure track

Chronic pain is a widespread problem that affects a third of Americans and greatly burdens the health care system. Despite its prevalence, chronic pain remains poorly understood, and the current clinical strategies are minimally effective. The application of advanced neuroimaging techniques to the study of chronic pain has significantly increased our understanding of the brain’s role in the development and maintenance of chronic pain, and through these studies, researchers have uncovered previously unknown neural processes involved in pain chronification. The spinal cord is the caudal extension of the brainstem and is actively involved in the modulation and transmission of neural signals between the body and the brain. Alterations in the neural processing in the spinal cord are also thought to have an integral role in pain chronification. Recent advancements in spinal cord neuroimaging have made the quantitative study of the spinal cord’s role in chronic pain possible. Expanding the neuroimaging-based investigation of chronic pain to the spinal cord will provide a complete perspective of the central processes underlying pain chronification. In this mentored career development award (K23), Dr. Weber will identify, characterize, and longitudinally track neuroimaging-based biomarkers for chronic pain in the brain and spinal cord using cervical radiculopathy as a model condition for chronic pain. Cervical radiculopathy is a common cause of neck and upper limb pain and provides a unique opportunity to scientifically study chronic pain in a homogenous patient sample. In Aims 1 and 2, Dr. Weber will identify differences in the brain and spinal cord networks between patients with chronic pain due to right-sided cervical radiculopathy and age- and sex-matched healthy controls. In Aim 3, clinical measures in the same cohort of cervical radiculopathy patients will be longitudinally tracked at 3, 6, 9, and 12 months after the imaging session, and neuroimaging-based prognostic factors contributing to pain reduction in cervical radiculopathy will be identified. In the same cohort of patients, the imaging will be repeated at 12 months, and the links between the changes in the brain and spinal cord and recovery will be explored. This research will move the pain field forward by further elucidating the neural processes underlying chronic pain and its recovery. Throughout the award period, Dr. Weber will obtain new skills and expertise in conducting clinical studies including randomized controlled trials and applying advanced computational methods to clinical pain research. Additionally, Dr. Weber will gain further training in advanced neuroimaging methods, pain neurobiology, career development, and grant writing. To accomplish the proposed research and training, Dr. Weber has assembled a multi-disciplinary team of world-class mentors who are committed to his success. This training will build on Dr. Weber’s clinical background and doctoral research training in neuroscience and ultimately provide him with the knowledge and skillset to establish an independent research program, in which, he will lead impactful scientific research that intersects neuroimaging and clinical pain research.

慢性疼痛是美国人的第三个问题，造成了医疗系统的负担。 RCHER在疼痛的调制和大脑中的调制和传播中都涉及疼痛的过程。脊髓在慢性的可能性。 ，使用宫颈疗法作为颈部疼痛的模型状况，用于大脑和脊髓的纵向生物标志物是颈部疼痛的常见原因。韦伯·韦伯（Weber Weber）的一个疾病样本。将在3、6、9个基于神经影像学的预后因素进行纵向跟踪，从而在同一患者中识别出有助于减轻宫颈自由病的疼痛的预后因素。进一步阐明神经过程在整个奖项期间恢复。为了获得成功的屁股导师将以韦伯博士的临床背景和神经科学的博士研究培训为基础神经影像学和临床疼痛研究。

项目成果

New insights into intrinsic foot muscle morphology and composition using ultra-high-field (7-Tesla) magnetic resonance imaging.

• DOI: 10.1186/s12891-020-03926-7
• 发表时间: 2021-01-21
• 期刊: BMC musculoskeletal disorders
• 影响因子: 2.3
• 作者: Franettovich Smith MM;Elliott JM;Al-Najjar A;Weber KA 2nd;Hoggarth MA;Vicenzino B;Hodges PW;Collins NJ
• 通讯作者: Collins NJ

Are Magnetic Resonance Imaging Technologies Crucial to Our Understanding of Spinal Conditions?

• DOI: 10.2519/jospt.2019.8793
• 发表时间: 2019-05-01
• 期刊: JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
• 影响因子: 6.1
• 作者: Crawford, Rebecca J.;Fortin, Maryse;Elliott, James M.
• 通讯作者: Elliott, James M.

The Problem of Pain in the United States: A Population-Based Characterization of Biopsychosocial Correlates of High Impact Chronic Pain Using the National Health Interview Survey.

美国的疼痛问题：使用国家健康访谈调查对高影响慢性疼痛的生物心理社会相关性进行基于人群的表征。

• DOI: 10.1016/j.jpain.2023.03.008
• 发表时间: 2023
• 期刊: The journal of pain
• 作者: Falasinnu,Titilola;Hossain,MdBelal;Weber2nd,KennethArnold;Helmick,CharlesG;Karim,MohammadEhsanul;Mackey,Sean
• 通讯作者: Mackey,Sean

Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury.

• DOI: 10.1016/j.apmr.2021.07.792
• 发表时间: 2022-01
• 期刊: Archives of physical medicine and rehabilitation
• 影响因子: 4.3
• 作者: Smith AC;O'Dell DR;Albin SR;Berliner JC;Dungan D;Robinson E;Elliott JM;Carballido-Gamio J;Stevens-Lapsley J;Weber KA
• 通讯作者: Weber KA

Generic acquisition protocol for quantitative MRI of the spinal cord.

• DOI: 10.1038/s41596-021-00588-0
• 发表时间: 2021-10
• 期刊: Nature protocols
• 影响因子: 14.8
• 作者: Cohen-Adad J;Alonso-Ortiz E;Abramovic M;Arneitz C;Atcheson N;Barlow L;Barry RL;Barth M;Battiston M;Büchel C;Budde M;Callot V;Combes AJE;De Leener B;Descoteaux M;de Sousa PL;Dostál M;Doyon J;Dvorak A;Eippert F;Epperson KR;Epperson KS;Freund P;Finsterbusch J;Foias A;Fratini M;Fukunaga I;Wheeler-Kingshott CAMG;Germani G;Gilbert G;Giove F;Gros C;Grussu F;Hagiwara A;Henry PG;Horák T;Hori M;Joers J;Kamiya K;Karbasforoushan H;Keřkovský M;Khatibi A;Kim JW;Kinany N;Kitzler H;Kolind S;Kong Y;Kudlička P;Kuntke P;Kurniawan ND;Kusmia S;Labounek R;Laganà MM;Laule C;Law CS;Lenglet C;Leutritz T;Liu Y;Llufriu S;Mackey S;Martinez-Heras E;Mattera L;Nestrasil I;O'Grady KP;Papinutto N;Papp D;Pareto D;Parrish TB;Pichiecchio A;Prados F;Rovira À;Ruitenberg MJ;Samson RS;Savini G;Seif M;Seifert AC;Smith AK;Smith SA;Smith ZA;Solana E;Suzuki Y;Tackley G;Tinnermann A;Valošek J;Van De Ville D;Yiannakas MC;Weber KA 2nd;Weiskopf N;Wise RG;Wyss PO;Xu J
• 通讯作者: Xu J