Pilot Projects Program Core

试点项目核心计划

• 批准号: 10438749
• 负责人: Heloise. ANNE Pereira
• 金额: $ 56.24万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10438749
• 关键词: Address; Affect; American Indians; Arthritis; Autoimmunity; Award; Basic Science; Cardiovascular Diseases; Cardiovascular system; Categories; Cessation of life; Clinical; Clinical Research; Clinical Sciences; Communities; Community Developments; Community Outreach; Country; County; Critiques; Development; Diabetes Mellitus; Diagnosis; Disease; Environment; Evaluation; Extramural Activities; Faculty; Feedback; Female; Financial Support; Fostering; Foundations; Funding; Funding Agency; Funding Opportunities; Future; Generations; Goals; Grant; Growth and Development function; Health; Health Benefit; Health Priorities; Howard Temin Award; Individual; Infrastructure; Institution; Leadership; Life Expectancy; Malignant Neoplasms; Medical Research; Mentors; Mentorship; Minority Groups; Mission; Modeling; Obesity; Oklahoma; Outcome; Patients; Personal Satisfaction; Phase Transition; Pilot Projects; Population; Prevalence; Principal Investigator; Program Sustainability; Publishing; Research; Research Design; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Rural Population; Scientist; Secure; Services; Severity of illness; Source; Structure; Talents; Testing; Tobacco use; Training; Translating; Translational Research; Tribes; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Writing; bridge program; care providers; career; career development; clinical care; clinical development; clinical infrastructure; community engaged research; community engagement; disability; health disparity; improved; innovation; medical schools; meetings; multidisciplinary; novel; opioid abuse; practical application; prevent; programs; response; rural dwellers; success; translational research program; tribal institution

Despite recent improvements, Oklahoma continues to have high rates of tobacco use, obesity, cancer deaths, and cardiovascular deaths, arthritis disability and an opioid abuse crisis. The mission of the OSCTR Pilot Projects Program (PPP) is to accelerate discoveries into Oklahoma's health priorities by fostering innovative and collaborative clinical and translational research (CTR) projects, leading to nationally and federally funded independent research programs. Our current pilot program has received 169 applications and funded 28 with >50% female and 37.5% of these PIs from under-represented minority populations. These pilot recipients have been immensely successful garnering a total of $17.2 M of PI-level extramural funding to these new investigators or a $7.60 ROI. To do this the PPP provides pilot project funding (Aim 1), coordinates infrastructure support and mentoring for pilot investigators (Aim 2), and identifies promising but unfunded junior investigators for additional mentoring (Aim 3). This strategy is built on the hypothesis that providing junior investigators with CTR funding, infrastructure, and mentorship will coalesce a new generation of well-trained, well-funded CTR scientists equipped to translate scientific discoveries into improved clinical care and patient well-being. In all of these functions, the PPP prioritizes research that addresses prominent health issues in Oklahoma and other IDeA states. To build on these early successes, maintain this dramatically different new trajectory for OSCTR new investigators and in response to Evaluation Core and EAC feedback, the PPP has expanded from one to three award types. CTR Pilot Awards, as previous, provide 12 months of funding for at least five novel research projects per year. To address the need for interim support while analyzing, publishing, and seeking extramural funding for pilot projects, competitive Pilot Sustainability Bridge Awards will provide 6 additional months of funding for up to 3 pilot recipients per year. Finally, to better support the unique needs of our partners, the Community-Engaged Research Exploratory Awards provide 6 months of funding for projects initiating new partnerships with non-academic institutions, such as tribal institutions, community development agencies, county health improvement organizations, health departments, and primary care providers. In addition to these OSCTR-funded awards, the PPP leverages other local funding programs when possible to provide larger or additional awards in each category. Beyond providing financial support, the PPP provides an environment that nurtures the continued success of these junior investigators. Upon funding, the Pilot Kickoff Meeting introduces awardees to the OSCTR Cores, Directors, and other awardees, and helps them critique each other's proposals. Throughout the award, investigators will receive structured mentoring (Professional Development Core) and training in scientific writing to foster career development and growth toward independence. The PPP assists current and past awardees, as well as promising but unfunded applicants, to identify additional funding sources and develop a strategy for securing independent, national funding.

尽管最近有所改善，但俄克拉荷马州的烟草使用率仍然很高，肥胖，癌症死亡， 以及心血管死亡，关节炎疾病和阿片类药物滥用危机。 OSCTR飞行员的任务 项目计划（PPP）是通过培养创新的，将发现加速进入俄克拉荷马州的健康优先事项 以及协作临床和转化研究（CTR）项目，导致全国和联邦政府资助 独立研究计划。我们当前的试点计划已收到169份申请，并资助了28个 > 50％的女性和37.5％的PI来自代表性不足的少数群体。这些飞行员​​收件人有 获得了巨大的成功，总共获得了$ 17.2 m的Pi-Level壁外资金 调查人员或7.60美元的投资回报率。为此，PPP提供试点项目资金（AIM 1），坐标 试点调查人员的基础设施支持和指导（AIM 2），并确定有希望但无资金的初级 调查人员进行额外指导（AIM 3）。该策略建立在提供初级的假设的基础上 CTR资金，基础设施和指导的调查人员将合并新一代训练有素的， 资金充足的CTR科学家，能够将科学发现转化为改善的临床护理和患者 福利。在所有这些功能中，PPP优先考虑解决研究中重大健康问题的研究 俄克拉荷马州和其他想法状态。为了建立这些早期的成功，请保持这种截然不同的新事物 OSCTR新研究人员的轨迹，并响应评估核心和EAC反馈，PPP具有 从一种奖励类型扩展到三种。以前，CTR飞行员奖提供了12个月的AT资金 每年至少五个新颖的研究项目。在分析，发布， 并寻求针对试点项目的壁外资金，竞争性的飞行员可持续发展桥将提供6个 每年最多3个试点接收者的额外资金。最后，更好地支持 我们的合作伙伴，社区参与的研究探索奖为项目提供6个月的资金 与非学术机构（例如部落机构，社区发展）建立新的伙伴关系 机构，县健康改善组织，卫生部门和初级保健提供者。在 除了这些OSCTR资助的奖项外，PPP在可能的情况下利用其他本地资助计划 在每个类别中提供更大或其他奖项。除了提供财政支持之外，PPP提供了 培育这些初级调查人员持续成功的环境。资金后，飞行员开球 会议向OSCTR核心，董事和其他获奖者介绍获奖者，并帮助他们批评 彼此的建议。在整个奖项中，调查人员将获得结构化的指导（专业人士 发展核心）和科学写作培训，以促进职业发展和成长 独立。 PPP协助当前和过去的获奖者以及有希望但没有资金的申请人 确定额外的资金来源，并制定确保独立的国家资金的战略。