A Data Resource for Analyzing Blood and Marrow Transplants

用于分析血液和骨髓移植的数据资源

• 批准号: 10369638
• 负责人: Bronwen Shaw
• 金额: $ 438.22万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369638
• 关键词: Address; Aftercare; Area; Biological; Biological Specimen Banks; Blood; Bone Marrow Transplantation; Cell Therapy; Cells; Cellular immunotherapy; Characteristics; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Data; Data Analyses; Data Collection; Databases; Development; Diagnosis; Disease; Donor person; Eligibility Determination; Funding; Generations; Genetic; Goals; HLA Antigens; Health Services; Hematopoietic Stem Cell Transplantation; Immunologics; Impairment; Individual; Infrastructure; International; Investigation; Link; Longterm Follow-up; Malignant - descriptor; Marrow; Medicine; Non-Malignant; Oligonucleotides; Organ; Outcome; Patient Outcomes Assessments; Patients; Play; Procedures; Process; Productivity; Prognostic Factor; Provider; Publications; Quality of life; Registries; Request for Applications; Research; Research Personnel; Research Support; Resolution; Resource Development; Resources; Risk; Role; Sampling; Science; Scientist; Series; Source; Specimen; Techniques; Technology; Time; Toxic effect; Transplant Recipients; Treatment-Related Cancer; United States; clinical database; clinical decision-making; clinical practice; data exchange; data resource; data sharing; design; genome sequencing; healthcare community; hematopoietic cell transplantation; improved; innovation; international center; novel; operation; patient subsets; policy implication; programs; randomized trial; repository; research study; simulation; stem; transplant registry; transplantation therapy; treatment comparison; treatment effect; treatment strategy; whole genome

PROJECT SUMMARY/ABSTRACT The Center for International Blood and Marrow Transplant Research (CIBMTR) is a clinical research program dedicated to addressing important issues in the field of hematopoietic cell transplantation (HCT). CIBMTR maintains a large outcomes registry with information for >475,000 HCT recipients in >420 centers and provides statistical support for analyzing those data. A separately funded Research Repository of donor-recipient specimens linked to these clinical data is available for a large subset of patients, as are data generated from analyses of these specimens, including high-resolution human leukocyte antigen (HLA) data and whole genome sequencing. Use of this Resource by thousands of investigators around the world during the current and previous funding cycles have contributed to >1,100 publications on important issues, to improved global collaboration in data exchange and HCT research and to increase the amount of data available to providers and patients for clinical decision-making. With renewal of U24-CA76518, CIBMTR will continue to build on the infrastructure made possible by this support to facilitate in-depth exploration of clinical, immunologic, genetic, quality of life, and health services issues related to HCT. This application proposes to enhance this Resource and to advance its utility through the following Specific Aims: Resource Development: Maintain and enhance CIBMTR’s high-quality clinical database and state-of-the-art statistical support to address important issues in HCT and related fields through continued development of state-of-the-art data collection, management and sharing technologies and procedures, expansion of infrastructure to capture patient-reported outcomes and cellular therapies, development and application of novel statistical techniques, and collaboration with national and international networks in HCT and related fields. Resource Utilization: Increase use of data and statistical resources maintained by the CIBMTR to support studies in malignant and non-malignant diseases with important clinical and policy implications, and enhance processes to prioritize and complete these studies.

项目概要/摘要 国际血液和骨髓移植研究中心 (CIBMTR) 是一个临床研究项目 致力于解决造血细胞移植（CIBMTR）领域的重要问题。 维护着一个大型结果登记处，其中包含超过 420 个中心的超过 475,000 名 HCT 接受者的信息，并提供 用于分析这些数据的统计支持。捐赠者-接受者单独资助的研究存储库。 与这些临床数据相关的样本可供大部分患者使用，生成的数据也是如此 对这些样本进行分析，包括高分辨率人类白细胞抗原 (HLA) 数据和整体 当前，世界各地数以千计的研究人员使用该资源。 和之前的资助周期已促成超过 1,100 份关于重要问题的出版物，以改善全球 数据交换和 HCT 研究方面的合作，并增加提供者可用的数据量 随着 U24-CA76518 的更新，CIBMTR 将继续在 U24-CA76518 的基础上发展。 这种支持使基础设施成为可能，以促进临床、免疫学、遗传、 与 HCT 相关的生活质量和健康服务问题 本申请旨在增强该资源。 并通过以下具体目标提高其效用： 资源开发：维护和增强 CIBMTR 的高质量临床数据库和最先进的技术 通过持续发展统计支持来解决 HCT 及相关领域的重要问题 最先进的数据收集、管理和共享技术和程序，扩展 捕获患者报告的结果和细胞疗法的基础设施、开发和应用 新颖的统计技术，以及与 HCT 和相关领域的国家和国际网络的合作 字段。 资源利用：增加对 CIBMTR 维护的数据和统计资源的使用，以支持 具有重要临床和政策意义的恶性和非恶性疾病研究，并加强 确定优先顺序并完成这些研究的流程。