Emotional Systems in Attention-Deficit/Hyperactivity Disorder

注意力缺陷/多动症的情绪系统

基本信息

批准号：
10368147
负责人：
Erica D Musser
金额：
$ 17.68万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-01 至 2025-03-01
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10368147
关键词：
Address Affect Amygdaloid structure Analysis of Covariance Arousal Attention Attention deficit hyperactivity disorder Autonomic nervous system Basic Science Behavior Behavioral Child Child Mental Health Childhood Clinical Cognition Disorders Data Analyses Development Diagnosis Disease Electrocardiogram Emotional Emotions Ethics Etiology Functional Magnetic Resonance Imaging Functional disorder Future Goals Heterogeneity Individual Insula of Reil Intervention Link Measures Mental Health Methods Modeling Nervous System Physiology Neuraxis Neurosecretory Systems Nucleus Accumbens Parasympathetic Nervous System Participant Pathway interactions Patient Self-Report Physiological Prevalence Process Psychiatry Psychology Psychophysiology Regulation Research Research Activity Respiration Rewards Role Route Sinus Arrhythmia Statistical Data Interpretation System Time Training Training Activity Translational Research Unconscious State Ventral Striatum Work Youth aged clinical care clinical diagnosis cognitive reappraisal computerized data processing data acquisition design disease classification emotion dysregulation emotion regulation emotional functioning executive function improved indexing neurobiological mechanism neuroimaging novel personalized approach positive emotional state programs respiratory response skill acquisition statistics theories

项目摘要

Project Summary/Abstract Attention-deficit/hyperactivity disorder (ADHD) is among the most common reasons for childhood mental health referral with a prevalence of 7.8-11%. Despite progress in the domains of basic and translational science, diagnosis and treatment of ADHD remain controversial, etiologies remain uncertain, and clinical prediction remains poor. A multi-method approach to examine mechanisms underlying the disorder is needed to inform both etiological studies and clinical planning. Although ADHD has often been conceptualized as a cognitive disorder with emphasis on attention, executive function, and temporal processing, work by the applicant and others has established the need to integrate emotion regulation into conceptualization of the disorder and clinical care. The ultimate goals of the proposed research and training activities are to develop an independent program of research examining emotion regulation in youth with ADHD, while utilizing multiple methods and tapping into multiple levels of analysis, including behavioral, as well as autonomic and central nervous system functioning. The applicant is already well-versed in behavioral and autonomic levels of analysis as these factors relate to emotional functioning in ADHD. Thus, the proposed training emphasizes skill development in: 1) neuroimaging (i.e., fMRI) task development and data acquisition 2) neuroimaging (i.e., fMRI) data processing and analysis, 3) advanced statistical analysis, 4) training in ethics and professional development. The proposed study seeks to examine the individual and combined effects of emotion regulatory systems (i.e., behavioral, autonomic and central nervous systems) across the domains of negative emotion, positive emotion, and effortful emotion regulation in ADHD. 120 child participants (70 with ADHD; aged 7-12 years) will complete an emotion induction and regulation task (EIRT). Participants will complete the EIRT while in an fMRI scanner with electrocardiogram and respiratory activity are recorded continuously (to index autonomic nervous system activity). This acquisition of this data will allow the applicant to address two inter-related aims, including to: Examine implicit (i.e., automatic, emotion reactivity) regulation of both negative and positive emotion (Aim 1), Examine explicit (i.e., effortful) emotion regulation of both negative and positive emotion (Aim 2) in youth with and without ADHD. These aims will be able to be addressed at multiple levels of analysis. The ultimate goal of this work over time will be to help sharpen psychiatric nosology and provide improved clinical diagnosis, characterization, and prediction, while also moving psychology and psychiatry toward more personalized approaches to treatment and to spur novel interventions.

项目摘要/摘要注意力缺陷/多动症（ADHD）是儿童精神的最常见原因之一健康转诊的患病率为7.8-11％。尽管基本和翻译领域取得了进展 ADHD的科学，诊断和治疗仍然有争议，病因仍然不确定，临床预测仍然很差。需要一种检查疾病基础机制的多方法方法为病因研究和临床计划提供信息。尽管多动症经常被概念化为认知障碍，重点是关注，执行功能和时间处理，由申请人和其他人已经确定了将情绪调节整合到概念化的需要疾病和临床护理。拟议的研究和培训活动的最终目标是开发独立研究研究多动症青年的情绪调节的独立计划，同时使用多个方法并利用多个级别的分析，包括行为，自主和中心神经系统功能。申请人已经在行为和自主层面上都精通分析这些因素与多动症中的情绪功能有关。因此，拟议的培训强调技能开发：1）神经影像学（即fMRI）任务开发和数据获取2）神经影像学（即 fMRI）数据处理和分析，3）高级统计分析，4）道德和专业培训发展。拟议的研究旨在检查情绪调节系统的个体和联合效果（即行为，自主神经和中枢神经系统）跨越负面情绪的领域，积极情绪和努力的情绪调节。 120名儿童参与者（70岁的ADHD； 7-12岁）将完成情感诱导和调节任务（EIRT）。参与者将在fMRI中完成EIRT 具有心电图和呼吸活性的扫描仪连续记录（索引自主神经神经系统活动）。对这些数据的收购将允许申请人解决两个相互关联的目的，包括到：检查隐性（即自动，情感反应性）对负面情绪和积极情绪的调节（目标 1），检查青年人对负面情绪和积极情绪的明确（即努力）情绪调节（目标2）有和没有多动症。这些目标将能够在多个分析层面上解决。最终随着时间的推移，这项工作的目标将是帮助提高精神病病学并提供改进的临床诊断，表征和预测，同时也将心理学和精神病学转向更个性化治疗方法和刺激新干预措施。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Talking about emotions: Effects of emotion-focused interviewing on children's physiological regulation of stress and discussion of the subjective elements of a stressful experience.

DOI：
10.1016/j.jecp.2020.104920
发表时间：
2020-10
期刊：
Journal of experimental child psychology
影响因子：
2.6
作者：
Klemfuss JZ;Musser ED
通讯作者：
Musser ED

Child maltreatment in the time of COVID-19: Changes in the Florida foster care system surrounding the COVID-19 safer-at-home order.

DOI：
10.1016/j.chiabu.2021.104945
发表时间：
2021-06
期刊：
Child abuse & neglect
影响因子：
4.8
作者：
Musser ED;Riopelle C;Latham R
通讯作者：
Latham R

Correction to: Role of empathy in the perception of medical errors in patient encounters: a preliminary study.

更正：同理心在患者遭遇医疗错误的认知中的作用：初步研究。

DOI：
10.1186/s13104-019-4518-3
发表时间：
2019
期刊：
BMC research notes
影响因子：
1.8
作者：
Hannan,Jean;Sanchez,Gabriel;Musser,EricaD;Ward-Peterson,Melissa;Azutillo,Elizabeth;Goldin,Deana;Lara,EdgarGarcia;Luna,AniuskaM;Galynker,Igor;Foster,Adriana
通讯作者：
Foster,Adriana

Child maltreatment online education for healthcare and social service providers: Implications for the COVID-19 context and beyond.