A comparison of environmental and genetic risks for schizophrenia and bipolar disorder: A Swedish national study

精神分裂症和双相情感障碍的环境和遗传风险比较：瑞典国家研究

基本信息

批准号：
10369024
负责人：
Sarah E Bergen
金额：
$ 29.54万
依托单位：
KAROLINSKA INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-18 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10369024
关键词：
Address Affect Age of Onset Attention Bipolar Disorder Birth Clinical Data Development Diagnosis Disease Environmental Exposure Environmental Impact Environmental Risk Factor Etiology Family Family history of Foundations Genes Genetic Genetic Risk Genotype Heritability Individual Infection Inherited Investigation Longevity Measures Molecular Genetics Pathway interactions Population Prevention Prevention strategy Public Health Recording of previous events Registries Reporting Research Resources Risk Risk Factors Role Sampling Scandinavian Schizophrenia Shapes Single Nucleotide Polymorphism Sweden Testing Work base childhood adversity comparative disorder risk genetic architecture genetic risk assessment genetic risk factor indexing informant marijuana use migration novel obstetrical complication personal narratives risk prediction schizophrenia risk severe psychiatric disorder societal costs therapeutic target

项目摘要

Abstract In this study we seek to understand how environmental factors influence the risk of developing schizophrenia (SZ) and bipolar disorder (BD) and how these risk factors interact with genetic risk for these disorders. SZ and BD are of major public health importance owing to their profound personal and societal costs. Major advances have been made in understanding the genetic architectures and specific loci conferring risk for these disorders individually and jointly. While robust, replicated findings for environmental risk factors for SZ have been identified, these have failed to materialize for BD. We intend to address to address this imbalance through parallel investigations of environmental risk for SZ and BD and explore possible interactions with genetic risk for these disorders. For this work, we will utilize data from the Swedish National Registers which contain data across the lifespan for the Swedish population (>10 million). Our first aim seeks to assess the impact of environmental risk factors on the development of SZ or BD and whether these are shared or divergent. These will include: urban living, infections, obstetric complications, migration, childhood adversity, cannabis use, and winter or spring birth. Additionally, an individual’s genes may differentially affect sensitivity to environmental exposures. Therefore, we will use both indirect (family history) and direct (molecular genetic) assessments of genetic risk for SZ and BD in relation to environmental exposures. Registry information available for this study is accurate and complete out to third degree relatives for total population measures of family history for these disorders (Aim 2). Existing molecular genetic data collected in Sweden for 10,059 SZ cases, 11,052 BD cases, and 22,138 controls will be used for analyses of directly measured genetic risk (Aim 3). Concurrent examination of BD and SZ will allow for direct comparisons of how environmental exposures act independently and in conjunction with genetic risk to shape these diagnoses. Elucidating the mechanisms which give rise to these related conditions may reveal opportunities for prevention efforts and therapeutic targets to ultimately reduce the personal and societal burdens of these devastating disorders.

抽象的在这项研究中，我们试图了解环境因素如何影响发展风险精神分裂症 (SZ) 和双相情感障碍 (BD) 以及这些危险因素如何与这些疾病的遗传风险相互作用 SZ 和 BD 因其深刻的个人和社会影响而具有重大的公共卫生重要性。在了解遗传结构和特定基因座方面取得了重大进展。单独和共同赋予这些疾病的风险，而环境方面的研究结果却是可靠的、可重复的。 SZ 的风险因素已确定，但 BD 的风险因素尚未实现。通过对深圳和BD的环境风险进行并行调查来解决这种不平衡，并探索与这些疾病的遗传风险可能存在相互作用。对于这项工作，我们将利用瑞典国家登记册中的数据，其中包含整个国家的数据瑞典人口的寿命（>1000 万）我们的首要目标是评估环境的影响。 SZ 或 BD 发展的风险因素以及这些风险因素是共同的还是不同的，其中包括：城市生活、感染、产科并发症、移民、童年逆境、大麻使用以及冬季或春天出生此外，个体的基因可能会不同地影响对环境暴露的敏感性。因此，我们将使用间接（家族史）和直接（分子遗传学）遗传评估本研究可获得的 SZ 和 BD 与环境暴露相关的风险。准确、完整地向三级亲属提供其家族史的总人口测量数据疾病（目标 2），在瑞典收集了 10,059 例 SZ 病例、11,052 例 BD 病例。病例，22,138 个对照将用于分析直接测量的遗传风险（目标 3）。同时检查 BD 和 SZ 将能够直接比较环境暴露的行为独立地并结合遗传风险来阐明这些诊断的机制。引起这些相关病症的因素可能会揭示预防和治疗的机会最终减少这些破坏性疾病给个人和社会带来的负担的目标。