CORE--CELL AND ANIMAL MODEL

核心--细胞和动物模型

• 批准号: 6893686
• 负责人: RANDALL H KRAMER
• 金额: $ 6.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6893686
• 关键词: biomedical facility; cell line; disease /disorder model; keratinocyte; laboratory mouse; mouth neoplasms; neoplastic growth; squamous cell carcinoma; tissue /cell culture; transfection

Important parts of several of the individually proposed research programs of this Program Project depend on the use of human oral squamous cell carcinoma cells and animal models for oral cancer development and progression. The Cell and Animal Model Core will provide the material required for these studies. Both malignant and normal keratinocyte cell lines, which are essential tools for the proposed studies are available. In addition, Core B will assist in the transfection of cells using retroviral vectors and in the performance of tumor invasion and migration assays. Another important task of the Core Facility will to make available several different animal models of oral cancer for the study of development, progression and invasion/metastasis.

该计划项目的几个单独提出的研究计划的重要部分取决于人类口腔鳞状细胞癌细胞和动物模型在口腔癌发生和进展中的使用。细胞和动物模型核心将提供这些研究所需的材料。 恶性和正常角质形成细胞系都是拟议研究的重要工具。此外，Core B 将协助使用逆转录病毒载体转染细胞以及进行肿瘤侵袭和迁移测定。核心设施的另一项重要任务是提供几种不同的口腔癌动物模型，用于研究其发展、进展和侵袭/转移。