Mentored Clinical Scientist Research Career Development Award

指导临床科学家研究职业发展奖

• 批准号: 9517094
• 负责人: Alexander M Friedman
• 金额: $ 16.61万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9517094
• 关键词: Adherence; Agreement; Antibiotics; Area; Biometry; Birth; Caring; Cesarean section; Characteristics; Childbirth; Clinical; Clinical Research; Clinical Trials; Complex; Coronary Artery Bypass; Data; Data Set; Development; Discipline of obstetrics; Epidemiologist; Epidemiology; Faculty; Fetal Distress; Fetal Heart Rate; Foundations; Goals; Gynecologic Oncologist; Health; Health Services Research; Healthcare; Hospitals; Human; Individual; Induced Labor; International; Intervention; Journals; K-Series Research Career Programs; Knowledge; Lead; Leadership; Measurement; Measures; Mechanics; Medical; Mentors; Mentorship; Methodology; Modeling; Morbidity - disease rate; Myocardial Infarction; Neonatal; Operative Surgical Procedures; Outcome; Outcomes Research; Patients; Performance; Perinatal; Physicians; Pneumonia; Population Research; Process Measure; Prophylactic treatment; Prostaglandins; Provider; Quality of Care; Recommendation; Reporting; Reproduction; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Risk Reduction; Scientist; Source; Statistical Methods; Streptococcus Group B; System; Thromboembolism; Time; Training; Trial of Labor; Vaginal delivery procedure; Variant; Venous; Woman; Work; adverse outcome; base; clinically relevant; comparative effectiveness; effectiveness research; experience; high risk; improved; innovation; intrapartum; lectures; mortality; neonatal outcome; novel; population based; preference; public health relevance; randomized trial; skills; symposium; translational scientist

 DESCRIPTION (provided by applicant): The purpose of this application for a Mentored Clinical Scientist Research Career Development Award (K08) is to allow the applicant sufficient protected time to 1) develop the statistical and methodological skills necessary to perform high quality health services research, 2) develop additional skills in study design and implementation, and 3) further develop leadership and management skills to lead a productive research team. In the long term, Dr. Friedman hopes to: 1) identify areas of sub-optimal care and health care variation using administrative datasets and data from large clinical trials, 2) identify optimal cae improvement strategies within the context of comparative effectiveness research, and 3) perform clinical research to assess the validity and benefit of quality improvement initiatives. Specifically, Dr. Friedman's plan includes a focus on developing an expertise in causal inference methodology, a framework of analysis that will allow him uniquely poised to perform high-impact research in his field. Through formal biostatistical training, active participation in analysis of complex datasets, close mentorship by Dr. Cande Ananth and Dr. Jason Wright, attending lectures, journal clubs, conferences, and symposia, and performing the research analysis evaluating intrapartum care quality outlined in the application, Dr. Friedman hopes to substantially enhance his capabilities as a researcher. Dr. Friedman has identified Dr. Wright and Dr. Ananth because of their expertise in epidemiology, biostatistics, and health outcomes research as well as their long track record of successfully mentoring junior faculty. Dr. Ananth is an internationally renowned perinatal epidemiologist whose research work focuses on developing and applying innovative statistical approaches to studies in human reproduction. Dr. Jason Wright is a gynecologic oncologist, experienced clinical trialist, translational researcher, and epidemiologist. Dr. Wright and Dr. Ananth are both committed to working closely with Dr. Friedman. With increased knowledge of the complexities of biostatistics and research methodology, Dr. Friedman will gain the ability to independently perform high-quality health outcomes research. He has identified a senior advisory panel to oversee his progress and will meet quarterly with this group. The research strategy for this application is a novel population-based care quality study evaluating candidate measures for quality of intrapartum care. To summarize the study, Dr. Friedman notes that little is known about baseline adherence to obstetric practices that may be representative of care quality during labor and childbirth and how physician, provider, and patient factors influence adherence. Given that there is no agreement on how to best measure the quality of obstetric care, valid measures of intrapartum care quality are urgently needed. With his excellent mentorship team, Dr. Friedman's research plan may result in clinically relevant and useful findings that improve maternal care.

 描述（由应用程序提供）：本申请的目的是指导临床科学家研究职业发展奖（K08），是为了使适当的足够保护的时间到1）开发进行高质量卫生服务研究所需的统计和方法学技能，2）开发研究设计和实施方面的其他技能，以及3）进一步的发展领导能力和管理技能，以领导一名有效的研究团队。从长远来看，弗里德曼博士希望：1）使用管理数据集和大型临床试验中的行政数据集和数据来确定次级护理和医疗保健变化的领域，2）在比较有效性研究的背景下确定最佳的CAE改进策略，3）进行临床研究，以评估质量改善倡议的有效性和益处。具体来说，弗里德曼（Friedman）博士的计划包括着眼于发展催化推理方法的专业知识，这是一个分析框架，它将使他在自己的领域中唯一中毒，从而在他的领域进行高影响力的研究。通过正式的生物稳定培训，积极参与复杂数据集的分析，Cande Ananth博士和Jason Wright博士的紧密心态，参加了讲座，期刊俱乐部，会议和聊天室，并进行研究分析，评估了弗里德曼博士在应用程序中概述的全部护理质量，弗里德曼博士希望实质上可以增强他的能力作为研究的能力。弗里德曼（Friedman）博士确定了赖特（Wright）博士和阿南斯（Ananth）博士，因为他们在流行病学，生物统计学和健康成果研究方面具有专业知识，以及他们成功心理的初级教师的长期记录。 Ananth博士是 国际知名的围产期流行病学家的研究工作着重于开发和应用创新的统计方法来进行人类生殖研究。杰森·赖特（Jason Wright）博士是妇科肿瘤学家，经验丰富的临床试验者，翻译研究人员和流行病学家。 Wright博士和Ananth博士都致力于与Friedman博士紧密合作。随着对生物统计学和研究方法的复杂性的了解，弗里德曼博士将获得独立执行高质量健康结果研究的能力。他已经确定了一个高级咨询小组来监督他的进度，并将季度与这个小组会面。该应用程序的研究策略是一项基于人群的新型护理质量研究，评估了候选手段护理质量的措施。总结这项研究，弗里德曼博士指出，对基线遵守产科实践的了解知之甚少，这种实践可能代表劳动和分娩期间的护理质量，以及身体，提供者和患者因素如何影响依从性。考虑到如何最好地衡量产科护理的质量，迫切需要迫切需要对产前护理质量的有效度量的共识。弗里德曼（Friedman）博士的研究计划凭借出色的心态团队，可能会导致临床相关和有用的发现，以改善物物护理。

项目成果

Hospital delivery volume, severe obstetrical morbidity, and failure to rescue.

• DOI: 10.1016/j.ajog.2016.07.039
• 发表时间: 2016-12
• 期刊: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
• 影响因子: 9.8
• 作者: Friedman, Alexander M.;Ananth, Cande V.;Huang, Yongmei;D'Alton, Mary E.;Wright, Jason D.
• 通讯作者: Wright, Jason D.

Maternal Outcomes by Race for Women Aged 40 Years or Older.

40 岁或以上女性按种族划分的产妇结果。

• DOI: 10.1097/aog.0000000000002751
• 发表时间: 2018
• 期刊: Obstetrics and gynecology
• 影响因子: 7.2
• 作者: Booker,WhitneyA;Gyamfi-Bannerman,Cynthia;Sheen,Jean-Ju;Wright,JasonD;Siddiq,Zainab;D'Alton,MaryE;Friedman,AlexanderM
• 通讯作者: Friedman,AlexanderM

Oral Opioid Use during Vaginal Delivery Hospitalizations.

阴道分娩住院期间口服阿片类药物的使用。

• DOI: 10.1055/s-0039-1678566
• 发表时间: 2020
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Mourad,Mirella;Landau,Ruth;Wright,JasonD;Siddiq,Zainab;Duffy,CassandraR;Kern-Goldberger,AdinaR;D'Alton,MaryE;Friedman,AlexanderM
• 通讯作者: Friedman,AlexanderM

Fragmentation of postoperative care after surgical management of ovarian cancer at 30 days and 90 days.

卵巢癌手术治疗后 30 天和 90 天的术后护理的碎片化。

• DOI: 10.1016/j.ajog.2019.09.005
• 发表时间: 2020
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Cham,Stephanie;Wen,Timothy;Friedman,Alexander;Wright,JasonD
• 通讯作者: Wright,JasonD

Postpartum readmissions among women with opioid use disorder.

患有阿片类药物使用障碍的女性产后再入院。

• DOI: 10.1016/j.ajogmf.2019.02.004
• 发表时间: 2019
• 期刊: American journal of obstetrics & gynecology MFM
• 影响因子: 6.3
• 作者: Wen,Timothy;Batista,Naralys;Wright,JasonD;D'Alton,MaryE;Attenello,FrankJ;Mack,WilliamJ;Friedman,AlexanderM
• 通讯作者: Friedman,AlexanderM