SUPPORT FOR THYROID CANCER AND OTHER THYROID DISEASES IN BELARUS

对白俄罗斯甲状腺癌和其他甲状腺疾病的支持

• 批准号: 10352179
• 负责人: ALEXANDER ROZHKO
• 金额: $ 15.38万
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2022-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10352179
• 关键词: Accidents; Address; Affect; Age; Area; Behavior; Belarus; Benign; Chernobyl Nuclear Accident; Clinical Data; Contracts; Data; Data Set; Disease; Dose; Evaluation; Exposure to; Hypothyroidism; Individual; Lesion; Life; Malignant Neoplasms; Malignant neoplasm of thyroid; Measurement; Measures; Medical; Mothers; Nodule; Pathology; Persons; Questionnaires; Radiation; Radioactive Iodine; Registries; Study Subject; Surveys; Thyroid Diseases; Thyroid Gland; Thyroiditis; Time; Uncertainty; Update; Vital Status; base; cohort; dietary; epidemiologic data; epidemiology study; follow-up; in utero; memory recall; neoplasm registry; nuclear power; screening; tumor

The contract is for the continuation of the “Study of Thyroid Cancer and Other Thyroid Diseases in Belarus”, a large-scale epidemiological study detecting thyroid and other pathology in persons who have been exposed to radiation as released by the accident at the Chernobyl Nuclear Power Station in April 26, 1986. The study involves two cohorts: (1) the “main cohort” that was established in the late 1990s and consists of 11,732 subjects who were age 18 or under at the time of the accident, had their dose to the thyroid gland measured, and lived in the Chernobyl affected areas in Belarus; and (2) the “in utero cohort” that was established in 2017 and consists of 2.965 persons who were exposed to Chernobyl fallout radiation in utero and early post-natal life. The main emphasis of this contract is to conduct medical screening for thyroid cancer and diseases in the recently established in-utero cohort. The main cohort, after having undergone three cycles of thyroid screening, transitioned to linkage-based passive follow-up. The specific objectives are: for the in utero cohort, (1) to conduct medical screening for thyroid cancer and thyroid non-cancer disease; (2) to evaluate the reliability of questionnaire-based doses previously reconstructed; for both the main and in utero cohorts: (3) to maintain passive follow-up to update occurrences of thyroid cancer, other cancer and thyroid non-cancer disease, through linkage with the Chernobyl State Registry and the National Belarusian Cancer Registry, (4) update demographic, clinical and epidemiologic data through a mail survey. Medical screening of in utero cohort focuses on thyroid cancer but also ascertain a wide spectrum of benign lesions, including benign tumors, nodules, functional changes (hyper- or hypothyroidism, thyroiditis, etc.), which have been associated with radioiodine exposure. Another important aspect of the study is the evaluation of uncertainty of questionnaire-based doses due to memory recall. NCI’s previous study shows that if dose-related measurements are available for study subjects, the quality of individual behavior and dietary data has, in general, a small influence on the results of the retrospective dose assessment. However, direct thyroid measurements are available only for around 15% of mothers of in utero cohort subjects; evaluation of uncertainty in doses due to possibly poor memory recall is important for this study. Another task for the contract is to update the dataset for the main and in-utero cohort with information obtained as a result of record linkage to the State Chernobyl Registry and National Belarusian Cancer Registry. We are also updating vital status and last known address for the subjects of main cohort through a mail survey.

该合同是为了延续“对白俄罗斯的甲状腺癌和其他甲状腺疾病的研究”，这是一项大规模的流行病学研究，检测到甲状腺和其他病理学的人，这些人暴露于事故中，在1986年4月26日的Chernobyl核电站在1986年4月26日的Chernobyl核电站上释放了辐射。在事故发生时，有11,732名年龄在18岁或以下的受试者中，他们的剂量对甲状腺进行了测量，并生活在白俄罗斯的切尔诺贝利受影响地区； （2）成立于2017年的“子宫同伴”，由2.965人组成，这些人暴露于子宫内和产后生命早期的切尔诺贝利辐射辐射。该合同的主要重点是在最近建立的UTERO人群中对甲状腺癌和疾病进行医学筛查。主要队列经过了三个甲状腺筛查周期后，转变为基于连锁的被动随访。 特定目标是：对于子宫同伴，（1）进行甲状腺癌和甲状腺非癌症的医学筛查； （2）评估先前重建的基于问卷的剂量的可靠性；对于主要和子宫同伴：（3）通过与切尔诺贝利州登记册和国家白俄罗斯癌症注册表的联系，（4）通过邮件调查更新人口统计学，临床和流行病学数据，以维持更新甲状腺癌，其他癌症和甲状腺非癌症发生的情况。 子宫群中的医学筛查集中在甲状腺癌上，但也确定了与良性病变的广泛良性病变，包括良性肿瘤，结节，功能变化（高甲状腺功能或甲状腺功能减退，甲状腺炎等），这些变化与放射性碘的暴露有关。该研究的另一个重要方面是评估由于记忆记忆而导致的基于问卷的剂量的不确定性。 NCI先前的研究表明，如果可用于研究对象，则个人行为和饮食数据的质量通常对回顾性剂量评估的结果产生了很小的影响。但是，直接的甲状腺测量仅适用于大约15％的子宫同类受试者的母亲。评估可能由于记忆不佳而导致的剂量不确定性对于这项研究很重要。 该合同的另一个任务是通过与州切尔诺贝利注册中心和国家白俄罗斯癌症注册表的记录联系而获得的主要和UTERO队列的数据集。我们还通过邮件调查来更新主体主题的重要状态和最后已知地址。