Proteomics Laboratory Shared Resources

蛋白质组学实验室共享资源

• 批准号: 10358547
• 负责人: Beatrix Magdalena Ueberheide
• 金额: $ 6.52万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10358547
• 关键词: Biochemistry; Biological; Cancer Center; Cancer Center Support Grant; Collaborations; Custom; Data Analyses; Doctor of Philosophy; Education; Educational process of instructing; Ensure; Experimental Designs; Individual; Label; Laboratories; Mass Spectrum Analysis; Mission; Molecular; Paper; Peptides; Pharmacology; Post-Translational Protein Processing; Postdoctoral Fellow; Preparation; Protein Analysis; Proteomics; Proteomics Shared Resource; Publications; Research; Research Personnel; Resource Sharing; Resources; Sampling; Scientist; Students; Technical Expertise; Techniques; Technology; Training; base; data analysis pipeline; experience; graduate student; hands on instruction; innovation; instrumentation; member; method development; novel; operation; professor; protein complex

Abstract/Project Summary PROTEOMICS RESOURCE LABORATORY SHARED RESOURCE (PRL) The Proteomics Resource Laboratory (PRL) provides support for mass spectrometry-based proteomics analysis for all Perlmutter Cancer Center (PCC) investigators through a centralized facility, with state-of-the-art instrumentation and highly specialized technical expertise. Under the direction of Dr. Beatrix Ueberheide, a well-established expert in biological mass spectromety, PRL was established 5 years ago to expand upon the successful Proteomics Core. PRL aids scientific discovery at PCC by providing access to specialized expertise and state-of-the-art instrumentation for the analysis of proteins and peptides using mass spectrometry (MS). A special focus of the laboratory is assistance with experimental design and full support for downstream data analysis, often involving innovative data analysis pipelines. Significant economies of scale are achieved by this centralization of resources. PRL achieves its mission via four Specific Aims: Aim 1) To provide mass spectrometry-based, state-of-the-art proteomics technologies to PCC investigators and full downstream data analysis support; Aim 2) To provide highly customized support tailored to specific projects and research questions of PCC investigators; Aim 3) To develop and implement novel techniques to ensure continued support of state-of-the-art proteomics technology for PCC investigators; Aim 4) To provide education to graduate students and post-doctoral researchers on proteomics techniques through graduate teaching and close collaboration with PCC investigators.

摘要/项目摘要 蛋白质组学资源实验室共享资源（PRL） 蛋白质组学资源实验室（PRL）为基于质谱的支持提供了支持 所有Perlmutter癌症中心（PCC）研究人员的蛋白质组学分析通过集中式研究者 设施，具有最先进的仪器和高度专业的技术专长。在下面 Beatrix Ueberheide博士的指导，生物质量的良好专家 Spectromety，PRL成立于5年前，以扩展成功的蛋白质组学 核。 PRL通过提供专业专业知识的访问权限来帮助PCC的科学发现和 最先进的仪器，用于使用质量分析蛋白质和肽的仪器 光谱法（MS）。实验室的特别重点是实验设计和 全面支持下游数据分析，通常涉及创新的数据分析管道。 通过这种资源集中化，可以实现重要的规模经济。 PRL成就 它通过四个特定目标的使命：目标1）提供基于质谱的最先进 PCC研究人员和完整的下游数据分析支持的蛋白质组学技术；目的 2）提供针对特定项目和研究问题的高度定制的支持 PCC调查人员；目标3）开发和实施新技术以确保继续 支持PCC研究人员最先进的蛋白质组学技术；目标4）提供 对蛋白质组学技术的研究生和博士后研究人员的教育 通过研究生教学和与PCC调查人员的密切合作。