Hot Flashes and Neurovascular Function in Women

女性潮热与神经血管功能

• 批准号: 10358626
• 负责人: Sarah Elizabeth Baker
• 金额: $ 16.26万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10358626
• 关键词: Adrenergic Agents; Aging; Area; Arteries; Baroreflex; Blood; Blood Vessels; Blood flow; Brain; Carbon Dioxide; Cardiovascular Diseases; Cerebrum; Clinical Trials; Complement; Cutaneous; Development; Endothelium; Evaluation; Feeling; Frequencies; Functional disorder; Goals; Hot flushes; Hypertension; Impaired cognition; Impairment; Incidence; Intervention; Knowledge; Learning; Life; Link; Lipids; Measures; Mediating; Menopause; Mentorship; Monitor; Mood Disorders; Muscle; Nerve; Obesity; Peripheral; Phenotype; Physiological; Physiology; Play; Prevention; Property; Regulation; Research; Resistance; Resolution; Rest; Risk; Risk Factors; Role; Running; Skeletal Muscle; Skin; Sleep; Sleep Disorders; Smooth Muscle; Stimulus; Sweating; Symptoms; System; Technical Expertise; Techniques; Tissues; Training; Vascular Endothelium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Vasomotor; White Matter Hyperintensity; Woman; Women' s Health; Work; cardiovascular disorder risk; career; career development; cerebrovascular; clinically relevant; design; diaries; effective intervention; experience; experimental study; heart rate variability; innovation; insight; middle age; neurotransmitter release; neurovascular; novel; prevent; response; stressor

PROJECT SUMMARY/ABSTRACT Vasomotor symptoms (hot flashes) associated with menopause consist of rapid and intense sweating, peripheral vasodilation, and an exaggerated feeling of internal heat. Over 70% of women experience hot flashes at some point during menopause, which significantly impacts day to day life. Furthermore, hot flash frequency is related to increased risk of hypertension, cardiovascular disease (CVD), sleep, and mood disorders--even when controlling for traditional cardiovascular disease risk factors (obesity, hypertension, lipids, etc.). As such, the overall goal of this application is to determine autonomic neurovascular function in midlife women with and without vasomotor symptoms (hot flashes). For the purposes of this application we will define neurovascular function as a concept that encompasses sympathetic outflow, the responses of blood vessels to neurotransmitters released by the sympathetic nerves and the intrinsic properties of the vascular endothelium and smooth muscle. It is thus related to the regulation of tissue blood flow. In this context, neurovascular function is critically important to women’s health and aging. Aim 1 will compare microvascular function in women with objectively assessed low and high frequency hot flashes. Aim 2 will determine autonomic function and reactivity in women with objectively assessed low and high frequency hot flashes. Finally, Aim 3 will characterize cerebrovascular function in women with objectively assessed low and high frequency hot flashes. Importantly, this work will provide the first comprehensive and mechanistic evaluation of autonomic and neurovascular function in midlife women including those undergoing menopause. Understanding how the neurovascular physiology of women relates to hot flashes will inform hypertension and cardiovascular disease (CVD) treatment and prevention options, as the presence of hot flashes are a CVD risk factor beyond traditional CVD risk factors and as such, is likely to be an important determinant for a woman’s health. Thus, the Applicant’s long-term goal is to develop interventions to reduce the incidence of cardiovascular disease in women with hot flashes. The proposed studies will build on the Applicant’s previous training and the mentorship team, formal course work on running clinical trials, and technical training plan will provide opportunities to gain additional knowledge in a new area and learn new experimental techniques and approaches. Finally, this work will generate an investigative niche that will complement the Applicant’s intellectual and technical skills that will facilitate the launch of her independent career.

项目摘要/摘要 与更年期相关的血管舒缩符号（潮热）包括快速而强烈的出汗， 外围血管舒张和内部热量的夸张感觉。超过70％的女性体验热 更年期期间的某个时刻闪烁，这显着影响了日常生活。此外，热潮 频率与高血压，心血管疾病（CVD），睡眠和情绪的风险增加有关 疾病 - 甚至在控制传统的心血管疾病危险因素时（肥胖，高血压， 脂质等）。因此，此应用的总体目标是确定自主神经血管功能 有和没有血管舒缩症状的中年妇女（潮热）。出于本申请的目的，我们将 将神经血管功能定义为包含交感神经出口的概念，是血液的反应 通过交感神经系统释放的神经递质的血管和血管的内在特性 内皮和平滑肌。因此，它与组织血流的调节有关。在这种情况下， 神经血管功能对妇女的健康和衰老至关重要。 AIM 1将比较微血管 具有客观评估低频和高频热闪光的女性的功能。 AIM 2将确定 具有客观评估低频和高频潮热的女性的自主功能和反应性。 最后，AIM 3将表征具有客观评估低和高的女性的脑血管功能 频率热闪烁。重要的是，这项工作将提供首个对 中年妇女在内的自主和神经血管功能，包括经历绝经的妇女。 了解与炎热相关的女性神经血管生理学如何为高血压和 心血管疾病（CVD）治疗和预防选择，因为潮热的存在是CVD风险 超出传统CVD风险因素的因素，因此可能是女性的重要决定因素 健康。这就是申请人的长期目标是制定干预措施，以减少事件 潮热的女性心血管疾病。拟议的研究将基于申请人以前的 培训和精神船队，进行临床试验的正式课程工作以及技术培训计划将 提供机会在新领域获得更多知识，并学习新的实验技术和 方法。最后，这项工作将产生一个调查性利基，将完成申请人的 智力和技术技能将有助于她独立职业的启动。