PrEParados: A Multi-Level Social Network Model to Increase PrEP Enrollment by Latino MSM Self-Identified as Gay, Bisexual

PrEParados：一种多层次社交网络模型，可提高自认是同性恋、双性恋的拉丁裔 MSM 的 PrEP 注册率

• 批准号: 10310530
• 负责人: Mariano Juan Kanamori Nishimura
• 金额: $ 54.27万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10310530
• 关键词: AIDS prevention; Address; Adherence; Alcohol consumption; Area; Bisexual; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinic; Communication; County; Development; Diphosphates; Disclosure; Drug usage; Ego; Emotional Bonds; Enrollment; Ensure; Epidemic; Ethnic group; Frequencies; Friends; Friendships; Future; Gays; General Population; Geography; HIV; HIV risk; Health; Hearing; Incidence; Information Services; Intervention; Knowledge; Latino; Latino Population; Learning; Measures; Mediation; Modeling; Motivation; Network-based; Outcome; Participant; Perception; Persons; Pharmaceutical Preparations; Population; Prevention Measures; Prevention strategy; Research Personnel; Respondent; Safe Sex; Sample Size; Sampling; Seeds; Sexual Health; Sexual Partners; Social Network; Structure; Study of Latinos; Subgroup; System; Tenofovir; Testing; Universities; Unmarried person; Work; base; cohesion; community organizations; male; men; men who have sex with men; metropolitan; network models; novel strategies; pre-exposure prophylaxis; pressure; programs; racial and ethnic; recruit; sex; sexual encounter; social; uptake

PROJECT SUMMARY PrEParados is a three-year developmental R01 study that will determine how social networks impact PrEP uptake and adherence among Latino men who have sex with men (LMSM), both those who self-identify as gay, and the unstudied group of LMSM who self-identify as bisexual/straight. This study will be implemented in Miami-Dade County (Miami), the epicenter of the HIV epidemic in the US. Among racial/ethnic groups in Miami, LMSM have the highest HIV incidence. Despite PrEP being the most effective HIV prevention measure currently available, few eligible LMSM in Miami are enrolled in a PrEP program (only 6% in 2018). Our preliminary study (N=130) suggests that social network structures may be contributing to LMSM’s low PrEP use. In that study of LMSM self-identified as gay, we discovered a large proportion of sexual encounters involved bisexual/straight LMSM. Self-identified bisexual/straight LMSM are a bridge between MSM—in whom the HIV epidemic is concentrated—and the general population in Miami. Before developing interventions, we need to implement this R01, which studies a larger sample to identify network configurations and dynamics impacting HIV risk among LMSM by their sexual self-identification (gay or bisexual/straight). To inform future interventions, our study will examine how social network structural factors suppress or promote access, encouragement, uptake, and adherence to PrEP. These findings will allow better deployment of accurate information and interventions, resulting in increased PrEP initiation and adherence amongst LMSM. PrEParados will study three social networks: 1) Friendship Networks—to identify social network mechanisms that promote PrEP use among LMSM friends in Miami. 2) Sexual Networks—to distinguish homophily and dyadic characteristics and dynamics associated with PrEP communication between sexual partners. 3) Venue Networks—to determine affiliations with geographic and online venues that could increase PrEP knowledge. Our established partnerships with Latinos Salud, Miami-Dade County Health Department PrEP Clinic, and the University of Miami’s Mobile PrEP Clinic and Rapid Access Wellness Clinic will provide access to 8,000+ LMSM, including 1,500+ PrEP users and 500+ who self-identify as bisexual/straight. This R01 study will provide new information that will allow PrEP interventions to include social network components and be tailored based on LMSM’s sexual self-identification. These new interventions could then serve as models for PrEP programs targeting males from other hard to reach populations.

项目摘要 Preeads是一项为期三年的发展R01研究，将决定社交网络如何影响PREP 与男人发生性关系的拉丁裔男人（LMSM）的吸收和遵守 同性恋者和未研究的LMSM群体，他们自我识别为双性恋/异性恋。这项研究将在 迈阿密戴德县（迈阿密），美国艾滋病毒流行的中心。在种族/族裔中 迈阿密，LMSM的HIV事件最高。尽管准备是最有效的HIV预防措施 目前可用的是，迈阿密很少有合格的LMSM参加PREP计划（2018年只有6％）。我们的 初步研究（n = 130）表明，社交网络结构可能有助于LMSM的低预备 使用。在对LMSM自我识别为同性恋的研究中，我们发现了很大一部分性交 涉及双性恋/直lmsm。自我识别的双性恋/直lmsm是MSM之间的桥梁 艾滋病毒的流行集中在迈阿密。在制定干预措施之前，我们 需要实施此R01，该R01研究了更大的样本以识别网络配置和动态 通过其性自我认同（同性恋或双性恋/直率）影响LMSM中的艾滋病毒风险。告知未来 干预措施，我们的研究将研究社交网络结构因素如何抑制或促进访问， 鼓励，吸收和遵守准备。这些发现将使精确部署更好 信息和干预措施，导致LMSM之间的准备计划和依从性增加。 Preeads将研究三个社交网络：1）友谊网络 - 确定社交网络机制 这促进了迈阿密LMSM朋友的准备使用。 2）性网络 - 与同质区分开 与性伴侣之间的准备沟通相关的二元特征和动态。 3）场地 网络 - 确定可能会增加准备知识的地理和在线场地的关联公司。 我们与拉丁裔萨鲁德（Latinos Salud），迈阿密戴德县卫生部预科诊所和 迈阿密大学的移动预科诊所和Rapid Access Wellness Clinic将提供8,000多个 LMSM，包括1,500多名预备用户和500多名自我识别为双性恋/直的用户。这项R01研究将 提供新信息，以允许准备干预措施包括社交网络组件并成为 根据LMSM的性自我认同量身定制。这些新干预措施然后可以作为模型 针对其他难以达到人口的男性的准备计划。