TJU Modernization of Bluemle Life Science Building Sanitation Facility

TJU Bluemle 生命科学大楼卫生设施现代化改造

• 批准号: 9119941
• 负责人: Judith S Daviau
• 金额: $ 50万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-21 至 2018-03-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119941
• 关键词: Ambulances; Animal Model; Animals; Area; Biological Sciences; Cardiac Surgery procedures; Caring; Censuses; Development; Environmental Impact; Equipment; Event; Faculty; Floor; Funding; Health; Health Risk Appraisals; Heart-Lung Machine; Housing; Human; Human Resources; IACUC; Immune; Immunocompromised Host; Infection; Laboratory Research; Longevity; Medicine; Military Personnel; Modeling; Modernization; Mus; Pathway interactions; Performance; Preventive Medicine; Principal Investigator; Protocols documentation; Research; Research Personnel; Rodent; Sanitation; Savings; Site; System; Systems Development; Tendon structure; Time; Transgenic Organisms; United States; Universities; Vaccines; War; Yellow Fever; animal care; animal facility; animal resource; medical schools; pathogen; programs

 DESCRIPTION (provided by applicant): This application seeks funding for a new tunnel washer and double door autoclave for the Bluemle Life Science Building (BLSB) animal facility at Thomas Jefferson University. Thomas Jefferson University (TJU) is one of the oldest academic health centers in the United States, with establishment of its Jefferson Medical College in 1824 (renamed the Sidney Kimmel Medical College at Jefferson in 2014). A number of alumni and faculty of Jefferson have made significant contributions to or have been involved in notable events in medicine. Among these are the development, during the Civil War, of the first military field ambulance system; discovery of the cause of yellow fever; development of the heart lung machine; performance of the world's first open heart surgery, development of the first preventative medicine health risk appraisal system and development of the first artificial tendon. TJU is dedicated to the humane care and use of animals in research and as such, operates USDA-, OLAW- and AAALAC-accredited facilities. A significant portion of the research portfolio includes the use of animal models. Currently there are 125 principal investigators conducting research under 376 IACUC-approved protocols on campus. Animal Resources currently operates a 24/7/365 facility in BLSB in approximately 16,700 sq. ft. of housing and animal care support space in a centralized configuration on the eleventh floor. The Bluemle Life Science Building (BLSB), built in 1991, houses the majority of rodents used in wet bench laboratory research. BLSB facilities represent about 62% of the entire TJU animal program by current census. Many of the current animal models are now transgenic and/or immunocompromised rodents. In addition to these models, investigators are now employing the use of pathogens, both human and murine, to identify immune pathways and potential vaccine target sites. This type of research poses challenges to both the animal care personnel and the researcher. It is imperative that the caging used is appropriately sanitized to protect the animals from unwanted confounding infections. Likewise it is critical that any real or potential hazardous agents are destroyed prior to entering common cage sanitation areas. Equipment which has exceeded its expected longevity results in multiple inefficiencies both in operational disruption and energy utilization. This application is requesting the replacement of existing tunnel washer and double-door autoclave that have been in use for more than 20 years. The procurement and installation of this equipment will result in increased personnel efficiency, less down time, significant operational savings and decreased negative environmental impact.

 描述（由申请人提供）：本申请为托马斯·杰斐逊大学 (TJU) 的 Bluemle 生命科学大楼 (BLSB) 动物设施寻求资金，该大学是最古老的学术健康中心之一。在美国，杰斐逊医学院于 1824 年成立（2014 年更名为杰斐逊西德尼·金梅尔医学院），杰斐逊医学院的许多校友和教职人员都为该学院做出了重大贡献。其中包括在内战期间开发出第一个军事野战救护系统；发现了黄热病的病因；开发了世界上第一个心脏直视手术；第一个预防医学健康风险评估系统的开发和第一个人工肌腱的开发致力于在研究中对动物进行人道护理和使用，因此，运营着经 USDA、OLAW 和 AAALAC 认证的设施。研究组合的目前，校园内有 125 名主要研究人员根据 376 个 IACUC 批准的协议进行研究，动物资源目前在 BLSB 运营着一个 24/7/365 的设施，拥有约 16,700 平方英尺的住房和动物护理支持。 Bluemle 生命科学大楼 (BLSB) 建于 1991 年，是湿台实验室研究中使用的大部分啮齿动物的集中空间。根据目前的普查，BLSB 设施约占整个 TJU 动物项目的 62%。除了这些模型之外，研究人员现在还使用人类和鼠类病原体。 ，以确定免疫途径和潜在的疫苗目标位点，这种类型的研究对动物护理人员和研究人员都提出了挑战，必须对所用的笼子进行适当的消毒，以保护动物免受不必要的混杂感染。任何实际或潜在的危险物质在进入普通笼式卫生区域之前都会被销毁。超出其预期寿命的设备会导致运行中断和能源利用效率低下。该设备的采购和安装将提高人员效率、减少停机时间、显着节省运营成本并减少对环境的负面影响。