Investigation of Embodiment for Upper Limb Amputees

上肢截肢者的躯体化研究

• 批准号: 10709524
• 负责人: Jacob Segil
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2026-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709524
• 关键词: Affect; Algorithms; Amputation; Amputees; Anxiety; Appearance; Area; Award; Back; Biomechanics; Body part; Chronic; Clinical; Cosmetics; Data; Data Collection; Data Set; Device or Instrument Development; Devices; Disabled Persons; Dorsal; Economics; Electrodes; Esthesia; Feedback; Future; Goals; Hand; Health Care Research; Illusions; Impairment; Implant; Individual; Investigation; Investments; K-Series Research Career Programs; Laboratories; Laboratory Study; Limb Prosthesis; Limb structure; Location; Measurement; Measures; Mechanics; Medical Device; Medical center; Mental Depression; Mentors; Mentorship; Methodology; Methods; Mission; Monitor; Myoelectric prosthesis; Numbness; Outcome Measure; Patients; Peripheral Nerve Stimulation; Peripheral Nerves; Persons; Physical Medicine; Physical Rehabilitation; Physiological; Procedures; Prosthesis; Protocols documentation; Psychophysics; Publications; Recording of previous events; Research; Rest; Rubber; Scientist; Sensory; Services; Social isolation; Surface; Surveys; System; Tactile; Technology; Testing; Time; Training; Travel; United States Department of Veterans Affairs; Upper Extremity; Veterans; Work; career; design; experience; experimental study; functional improvement; grasp; improved; invention; limb amputation; multimodality; myoelectric control; neural; neural implant; novel; physically handicapped; powered prosthesis; pressure; prosthetic hand; psychosocial; recruit; rehabilitation research; research and development; restoration; self esteem; sensor; sensory feedback; sensory prosthesis; somatosensory; tool; transradial amputee

Project Summary Today, prosthetic hands are numb. They provide no tactile or proprioceptive sensory information back to the user. The lack of sensory feedback has been shown to reduce the utility of a prosthesis by half. The prosthesis is seen as a tool, not as an incorporated part of the body schema. Only now are there chronically-implantable technologies which can provide physiologically appropriate sensory feedback to upper limb amputees to recreate tactile and proprioceptive percepts. These sensations are the building blocks to enable the embodiment of the device. Furthermore, newly developed outcome measures are now available which can detail the improved embodiment such neural interfaces can create. My mission is to enable the embodiment of artificial devices using peripheral nerve stimulation and thereby close the gap between the experience of our intact physiological systems and those using prosthetic remedies. This investigation of embodiment for upper limb amputees is organized into three main areas of work including 1) normative data collection, 2) device development, and 3) characterization of embodiment using peripheral nerve stimulation. The normative data collection will quantify the embodiment of conventional cosmetic, body-powered, and myoelectric prosthetic hand options using a modified Rubber Hand Illusion protocol (Specific Aim 1). This thrust will ask how does the amount of embodiment vary among conventional prosthetic hands as well as probe the relationship between agency and embodiment. The device development project entails the design of multi-modal sensors in order to study full-hand embodiment (Specific Aim 2). The ability to measure and then elicit sensation on the passive surfaces of the hand (palm, ulnar border, and dorsal surface) has never been explored. Here, a multi-modal sensor which can detect proximity, contact, and force will be integrated into a commercially available prosthetic hand in order to provide detailed measurements across the palm, ulnar border, and dorsal surfaces in order to study embodiment in more depth. Finally, the characterization of embodiment using peripheral nerve stimulation will take place over a multiple subject factorial experiment which quantifies the effects of quantity and spatial parameters of the peripheral nerve stimulation on the embodiment of prosthetic hands (Specific Aim 3). This study asks what somatosensory percepts from the hand are most critical for embodiment by varying the parameters of the peripheral nerve stimulation (quantity and spatiality) and measuring the level of embodiment in each case. This investigation will be the first thorough (multiple subjects with peripheral nerve interfaces), systematic (paired factorial design), and exhaustive (using all electrodes in the neural interface) study to be performed. Finally, an additional goal to the scientific mission of this proposal is the creation of the Neural Interface and Sensory Restoration Laboratory in the Rocky Mountain Regional VA Medical Center. I will direct this laboratory to be a complementary entity to Dr. Tyler’s Functional Neural Interface Laboratory to study peripheral nerve interfaces with upper limb amputees in the VA RR&D division. Now, more advanced methodologies can be explored and more scientific breakthroughs can be initiated with the goal of providing Veterans with amputation an artificial limb, as opposed to just a prosthetic tool.

项目概要 如今，假手已麻木，无法提供触觉或本体感觉。 向用户返回信息的缺乏已被证明会降低效用。 假肢被视为一种工具，而不是身体的一部分。 直到现在才有可以长期植入的技术。 为上肢截肢者提供生理上适当的感觉反馈，以重建触觉和触觉 这些感觉是实现具体化的基石。 此外，现在可以使用新开发的结果测量方法。 详细介绍这种神经接口可以创建的改进实施例，我的任务是实现。 使用周围神经刺激的人工装置的实施例，从而缩小间隙 我们完整的生理系统的经验和使用假肢疗法的经验之间的差异。 对上肢截肢者的外观调查分为三个主要领域： 工作包括 1) 规范数据收集，2) 设备开发，以及 3) 表征 使用周围神经刺激的实施例将量化规范数据收集。 传统美容、身体动力和肌电假手的体现 使用修改后的橡胶手错觉协议的选项（具体目标 1）。 传统假手之间的变化量如何？ 探究代理与实施例之间的关系。 需要设计多模态传感器以研究全手实施例（具体目标 2) 测量并引发手部被动表面（手掌、 尺骨边界和背侧表面）从未被探索过。 可以检测接近、接触和力将被集成到商用 假手，以便提供手掌、尺骨边界和 背面，以便更深入地研究实施例最后，表征。 使用周围神经刺激的实施例将在多个受试者阶乘上进行 量化外围设备数量和空间参数影响的实验 对假手实施例的神经刺激（具体目标 3）。 通过改变手的体感感知对于体现来说最关键 周围神经刺激的参数（数量和空间）并测量 该调查将是第一次彻底（多个主题）。 具有周围神经接口）、系统性（配对因子设计）和详尽性（使用所有 神经接口中的电极）进行研究。 最后，该提案的科学使命的另一个目标是创建神经网络 落基山地区 VA 医疗中心界面和感觉恢复实验室 我将指导该实验室成为泰勒博士功能实验室的补充实体。 神经接口实验室研究上肢截肢者的周围神经接口 现在，VA RR&D 部门可以探索更先进的方法等等。 可以启动科学突破，目标是为退伍军人提供截肢和 假肢，而不仅仅是假肢工具。