Pediatric Cardiovascular and Pulmonary Research Training Program

儿科心血管和肺研究培训计划

• 批准号: 9214237
• 负责人: THOMAS W FERKOL
• 金额: $ 36.88万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9214237
• 关键词: Cardiovascular system; Childhood; Lung; Research Training; Training Programs

 DESCRIPTION (provided by applicant): This is a new application or a training program designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of childhood diseases related to cardiovascular and pulmonary biology. The need for a training program in the cellular/molecular basis of cardiovascular and pulmonary disease, especially of physician scientists interested in childhood diseases, is based upon clear evidence of a small, national pool of such individuals as faculty or trainees. Currently, few pediatric cardiology or pulmonary fellowship programs in American medical centers provide adequate training in this area of research, either at the bench or in structured clinical investigation. Our program is designed to address this need from two important perspectives: 1) To allow pediatric and other clinical fellows with an interest in basic research to develop research competence and career training; 2) To attract and train talented basic scientists to study mechanism related to childhood diseases. Our program restructuring reflects a rethinking of a training program that for 16 years successfully trained scientists and clinicians in areas of basic and clinical research. This new program has been shaped by feedback from reviewers of the previous program, by advice from our faculty and program advisors, by past trainees, and by the formation of new core programs at Washington University that allow us to expand the training experience of our trainees. In addition to continuing our strong training in developmental/cell biology and the molecular basis of disease, our new program will take advantage of institutional strengths in genetics, stem cell biology, genomics, and bioinformatics-all of which are components of the foundation of modern research. We have adopted a training curriculum for 4 postdoctoral (multiple PGY levels) and 2 predoctoral fellows with an uninterrupted 2-3 year block of full-time investigation. This is combined with an integrated and multidisciplinary set of didactic seminars, journal clubs and formal courses that are selected by the trainee in consultation with the mentor/program administrators to provide individualized education in key aspects of cardiopulmonary development and disease. Our objectives are: 1) to provide extensive mentoring to the trainee for career development and for developing independent research plans that focus on pediatric diseases; 2) to promote training in basic cell and molecular biology, genomics, and bioinformatics together with clinical translational research; 3) to guide the trainees' development so that, after the completion of training, successful competition for independent funding is likely.

 描述（由申请人提供）：这是一个新的应用程序或培训计划，旨在吸引和培训博士前和博士后研究人员进行与心血管和肺部生物学相关的儿童疾病的基础研究。需要细胞/分子培训计划。心血管和肺部疾病的基础，特别是对儿童疾病感兴趣的医师科学家的基础，是基于一小部分全国性的个人（如教师或实习生）的明确证据。目前，美国医疗中心很少有儿科心脏病学或肺部奖学金计划提供足够的证据。该领域的培训研究，无论是在实验室还是在结构化的临床研究中。 该计划旨在从两个重要角度满足这一需求：1）让对基础研究感兴趣的儿科和其他临床研究员发展研究能力和职业培训；2）吸引和培训有才华的基础科学家来研究与儿童相关的机制。我们的项目重组反映了对 16 年来在基础和临床研究领域成功培训科学家和主教的培训项目的重新思考。这个新项目是根据之前项目评审者的反馈以及我们的教员和专家的建议制定的。项目顾问、过去的学员、通过在华盛顿大学建立新的核心项目，使我们能够扩大学员的培训经验 除了继续我们在发育/细胞生物学和疾病分子基础方面的强大培训外，我们的新项目还将利用机构优势。我们在遗传学、干细胞生物学、基因组学和生物信息学方面的优势——所有这些都是现代研究基础的组成部分，我们采用了针对 4 名博士后（多个 PGY 级别）和 2 名博士前研究员的培训课程，并提供不间断的 2-3 个课程。一年的全日制调查与一套综合的、多学科的教学研讨会、期刊俱乐部和正式课程相结合，这些课程由学员与导师/项目管理人员协商选择，以提供心肺发育关键方面的个性化教育。我们的目标是：1) 为学员​​的职业发展和制定专注于儿科疾病的独立研究计划提供广泛的指导；2) 促进基础细胞和分子生物学、基因组学和生物信息学以及临床的培训；翻译的研究；3）指导受训者的发展，以便在培训完成后，有可能成功竞争独立资助。