Family Centered Approaches to Promoting Cascade Screening for Hereditary Cancer Syndromes among African Americans

以家庭为中心的方法促进非裔美国人遗传性癌症综合征的级联筛查

基本信息

批准号：
10708884
负责人：
Katrina Renee Ellis
金额：
$ 17.28万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-21 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10708884
关键词：
Active Learning Adult African American African American population Anxiety Area Attitude Award Behavior Behavioral Behavioral trial Belief Breast Cancer Burden Clinic Colorectal Communication DNA Sequence Alteration Data Death Rate Development Diet Educational Status Educational workshop Ethnic Population Evaluation Extended Family Face Faith Family Family Caregiver Family health status Focus Groups Future Generations Genetic Genetic Counseling Germ-Line Mutation Goals Grant Health Health behavior Health education Hereditary Breast and Ovarian Cancer Syndrome Hereditary Malignant Neoplasm Hereditary Neoplastic Syndromes Individual Inherited Intervention Intervention Studies K-Series Research Career Programs Knowledge Learning Life Longitudinal Studies Malignant Neoplasms Manuscripts Medical Genetics Mental Health Mentored Research Scientist Development Award Mentors Modification Outcome Outcome Study Pattern Persons Physical activity Politics Population Positioning Attribute Process Public Health Recommendation Recording of previous events Reporting Research Research Personnel Resources Risk Self Determination Smoking Social Work Social status Spirituality Test Result Testing United States Writing acceptability and feasibility behavior change cancer genetics cancer health disparity cancer risk cancer type career career development commune communication theory contextual factors coping eHealth economic disparity experience genetic information genetic testing health disparity hereditary risk high risk improved improved outcome intervention program lifestyle intervention motivational enhancement therapy pilot test post-doctoral training psychosocial racial population randomized, clinical trials response screening skills symposium tailored messaging testing uptake theories therapy design therapy development transmission process uptake

项目摘要

Research has shown that African Americans are less likely than other racial groups to engage in genetic testing for hereditary cancer syndromes, which can uncover genetic mutations that increase cancer risk. African Americans also have lower rates of cancer cascade testing, a process for providing genetic counseling and testing for relatives of African Americans who are known carriers of specific cancer-related genetic mutations. As clinical genetic testing becoming increasingly available, it is critically important to design interventions to reach all populations, especially those that have been traditionally underserved. Tailored strategies are particularly useful for increasing intervention access and uptake where health disparities exist. This career development award provides Dr. Ellis the opportunity to develop and test a family-tailored intervention to increase cancer cascade testing among African Americans. This award focuses on strengthening the investigator’s skills in intervention research and cancer genetics. Her long-term career goal is to become an independent investigator with expertise in conducting family-based intervention research to improve cancer outcomes among African Americans. Dr. Ellis’ graduate-level training in public health (health behavior and education) and social work (interpersonal practice with individuals and families), and postdoctoral training in cancer health disparities, puts her in a unique position to develop interventions that attend to both the psychosocial and behavioral aspects of cancer genetic testing for African American families. The career development goals and mentoring plan include courses and workshops; guided mentoring, including directed readings with mentors; experiential learning, including shadowing in a cancer genetics clinic and intervention development, testing, and evaluation; tailored health messaging development; attendance and participation at professional conferences; and, manuscript and grant writing and submissions. These activities support the execution of the specific aims, which are to: (1) Identify intrapersonal and interpersonal facilitators and barriers to African American family communication about genetic testing and cascade testing through eight focus groups; (2) Develop a tailored, eHealth intervention for African American families that encourages uptake of recommended cascade genetic testing by improving communication about genetic testing results and targeting drivers of and barriers to behavior change (e.g., knowledge, attitudes, skills for communication and testing); (3) Conduct a pilot test of the intervention with 30 families to evaluate intervention feasibility, acceptability and engagement and explore its potential impact on cascade testing. Dr. Ellis’ mentoring team has expertise in each of her key developmental areas. At the completion of this K01 award, Dr. Ellis will have the expertise to become an independent investigator who conducts family-based intervention research to improve cancer outcomes with African American families with increased cancer risk.

研究表明，与其他种族群体相比，非裔美国人从事遗传研究的可能性较小检测遗传性癌症综合症，可以发现增加癌症风险的基因突变。非裔美国人的癌症级联测试（一种提供遗传咨询的过程）的比率也较低对已知携带特定癌症相关基因的非裔美国人亲属进行检测随着临床基因检测变得越来越可用，设计变得至关重要。干预措施覆盖所有人群，特别是传统上服务不足的人群。在存在健康差距的情况下，战略对于增加干预措施的获取和采用特别有用。该职业发展奖为埃利斯博士提供了开发和测试家庭定制的机会该奖项的重点是增加非裔美国人癌症级联检测的干预措施。加强研究者在干预研究和癌症遗传学方面的技能。她的长期职业目标。是成为一名独立调查员，具有进行基于家庭的干预研究的专业知识改善非裔美国人的癌症结果。埃利斯博士的公共卫生研究生水平培训（健康）行为和教育）和社会工作（与个人和家庭的人际实践），以及博士后癌症健康差异方面的培训使她处于独特的地位，可以制定针对这两方面的干预措施非裔美国家庭癌症基因检测的心理社会和行为方面。发展目标和指导计划包括课程和研讨会，包括定向指导；与导师一起阅读；体验式学习，包括在癌症遗传学诊所进行跟踪和干预开发、测试和评估；定制健康信息开发；出席和参与专业会议；以及手稿和资助的写作和提交。执行具体目标，即： (1) 识别个人内部和人际交往的促进因素和障碍通过八个重点与非裔美国家庭沟通基因检测和级联检测 (2) 为非裔美国家庭制定量身定制的电子卫生干预措施，鼓励他们采用通过改善基因检测结果和目标的沟通，推荐级联基因检测行为改变的驱动因素和障碍（例如，沟通和测试的知识、态度、技能）；对 30 个家庭进行干预试点测试，评估干预措施的可行性、可接受性和参与并探索其对级联测试的潜在影响。埃利斯博士的指导团队在这方面拥有专业知识。获得 K01 奖项后，埃利斯博士将拥有以下专业知识：成为一名独立研究者，进行以家庭为基础的干预研究以改善癌症癌症风险增加的非裔美国家庭的结果。