Administrative Core

行政核心

• 批准号: 10709633
• 负责人: John W Osborn
• 金额: $ 22.33万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709633
• 关键词: Advocate; Anatomy; Autonomic nervous system; Budgets; Calendar; Cardiovascular system; Clinical; Clinical Research; Clinical Trials Design; Collaborations; Communication; Complex; Contracts; Data; Ensure; Event; Feedback; Future; Goals; Head; Health Insurance Portability and Accountability Act; Human Resources; Immune system; Institution; Link; Medical; Metabolic; Minnesota; Nerve; Newsletter; Operative Surgical Procedures; Patients; Productivity; Reporting; Research; Research Personnel; Scientist; Secure; Surgeon; System; Transfer Agreement; United States National Institutes of Health; Universities; Update; data exchange; experience; interest; journal article; meetings; member; metabolomics; multidisciplinary; neuroregulation; participant enrollment; payment; therapy design; web site

ADMINISTRATION CORE Abstract The proposed Research Evaluating Vagal Excitation and Anatomical Linkages (REVEAL) center aims to conduct groundbreaking research on the effect of vagal nerve stimulation (VNS) on four key systems: the autonomic nervous system, the cardiovascular system, the immune system, and the metabolic system. The ambitious scope of the research requires the participation of eight major academic and medical institutions with over 40 participating key personnel, over 140 patients, an External Advisory Board (which includes patient advocates), and an NIH Steering Committee and other NIH personnel. As such, a well-planned, well-organized, and well- staffed Administration Core is crucial to coordinate the many REVEAL stakeholders so that the center can achieve its goals and produce foundational data for new VNS research and new VNS-based therapies. The Administration Core for REVEAL will be led by two medical scientists from the University of Minnesota (UMN) who have complimentary scientific expertise and extensive experience leading multidisciplinary teams: Dr. John Osborn (REVEAL Director), an expert in the autonomic nervous system and the director of the Minnesota Consortium for Autonomic Neuromodulation, and Dr. Sayeed Ikramuddin (Reveal MPI), Head of the UMN Department of Surgery and a clinical researcher and surgeon with experience in clinical trial design of interventions on metabolomic endpoints. The main goals of the Administration Core are to facilitate interactions between the Cores and Ancillary Projects to maximize REVEAL’s productivity; coordinate all REVEAL meetings, including an Annual VESPA Meeting; ensure clear lines of communication between Project/Core PIs, the NIH, and external groups; and manage the REVEAL budget and finances.

行政核心摘要 拟议的迷走神经兴奋和解剖联系评估研究（REVEAL）中心旨在针对迷走神经刺激（VNS）对四个关键系统的影响进行开创性研究：自主神经系统、心血管系统、免疫系统和代谢系统这项研究规模宏大，需要 8 个主要学术和医疗机构的参与，其中包括 40 多名参与关键人员、140 多名患者、一个外部顾问委员会（包括患者倡导者）和一个 NIH 指导委员会，因此，一个计划周密、组织良好、人员配备齐全的管理核心对于协调众多 REVEAL 利益相关者至关重要，以便该中心能够实现其目标并为新的 VNS 研究和新的 VNS 提供基础数据。 REVEAL 的管理核心将由明尼苏达大学 (UMN) 的两名医学科学家领导，他们拥有互补的科学专业知识和领导多学科团队的丰富经验：约翰·奥斯本 (John Osborn) 博士（REVEAL 主任），一位自主神经专家。系统。系统和明尼苏达自主神经调节联盟主任，以及 UMN 外科系主任、临床研究员和外科医生 Sayeed Ikramuddin 博士（Reveal MPI），他们在代谢组学终点干预措施的临床试验设计方面拥有丰富的经验。行政核心的职责是促进核心项目和辅助项目之间的互动，以最大限度地提高 REVEAL 的生产力，包括年度 VESPA 会议；项目/核心 PI、NIH 和外部团体；并管理 REVEAL 预算和财务。