Cortical VIP interneurons: behavioral recruitment, circuit mechanisms and subtypes

皮质 VIP 中间神经元：行为募集、回路机制和亚型

• 批准号: 10214703
• 负责人: Adam Kepecs
• 金额: $ 34.45万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10214703
• 关键词: 3-Dimensional; Acetylcholine; Address; Architecture; Area; Auditory area; Automobile Driving; Behavioral; Brain; Brain region; Calcium; Cholecystokinin; Complex; Cues; Data; Disinhibition; Dorsal; Evaluation; Feedback; Fiber; Image; Interneurons; Learning; Maps; Neocortex; Neurons; Optics; Outcome; Pathway interactions; Photometry; Population; Prefrontal Cortex; Property; Psychological reinforcement; Punishment; Pyramidal Cells; Rabies; Rewards; Role; Signal Transduction; Somatosensory Cortex; Source; System; Techniques; Testing; Time; Tracer; Variant; Vasoactive Intestinal Peptide; Visual Cortex; basal forebrain; base; cell type; cholinergic; expectation; genetic approach; in vivo; neuroregulation; operation; optogenetics; rabies viral tracing; raphe nuclei; receptor; recruit; reinforcer; response; two-photon

Project Summary/Abstract The complex architecture of cortical microcircuits is thought to comprise variations of canonical microcircuits that perform elemental computations. In the midst of specialized local computations, cortex also receives global input from a variety of long-range neuromodulatory centers. This proposal investigates the relationship between these two types of circuits. A recently identified cortical circuit motif is controlled by a class of interneurons defined by their expression of vasoactive intestinal polypeptide (VIP), which disinhibit pyramidal cells across four distinct cortical areas, thus defining a canonical cortical circuit. These VIP interneurons in the auditory cortex are recruited in response to reinforcement signals (reward and punishment), which are likely driven by neuromodulatory systems. Therefore the dual objectives of this proposal are to determine both the generality of VIP recruitment by reinforcement signals and the circuit mechanisms responsible for this activity. First we will evaluate the cortex-wide generality of VIP interneuron recruitment by reinforcers using a combination of sophisticated techniques for neuron identification and evaluation of their activity. Second, we will identify which inputs drive reinforcement responses in VIP neurons. We will map all common regions across the brain that provide inputs to cortical VIP neurons, with a focus on the cholinergic and serotonergic neuromodulatory systems and determine the pathway(s) causally responsible. Finally, we will determine how different subtypes of VIP neurons are recruited and driven. Completion of these aims should reveal fundamental principles of how the VIP- controlled cortical microcircuit functions cortex-wide and serves as a conduit for fast neuromodulatory control.

项目摘要/摘要 皮质微电路的复杂结构被认为包括 执行元素计算的规范微电路的变化。在 在专门的本地计算中，Cortex还从一个 多种远程神经调节中心。该提案调查了 这两种类型的电路之间的关系。 最近确定的皮质电路基序由一类中间神经元控制 由它们表达的血管活性肠多肽（VIP）定义 在四个不同的皮质区域上抑制了锥体细胞，从而定义了 规范皮质电路。听觉皮层中的这些VIP中间神经元是 招募响应强化信号（奖励和惩罚）， 可能是由神经调节系统驱动的。因此 该建议是通过确定VIP招募的一般性 强化信号和负责此活动的电路机制。 首先，我们将通过 增强剂结合了神经元的复杂技术 识别和评估其活动。其次，我们将确定哪些输入 VIP神经元中的增强反应。我们将绘制所有常见区域 在为皮质VIP神经元提供输入的整个大脑中，重点是 胆碱能和血清素能神经调节系统，并确定 途径（S）因果负责。最后，我们将确定与众不同 VIP神经元的亚型被招募和驱动。 这些目标的完成应揭示有关贵宾如何的基本原则 受控的皮质微电路功能范围宽，并用作管道 快速神经调节控制。

项目成果

Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types.

• DOI: 10.1038/s41593-020-0648-0
• 发表时间: 2020-08
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Laszlovszky T;Schlingloff D;Hegedüs P;Freund TF;Gulyás A;Kepecs A;Hangya B
• 通讯作者: Hangya B

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment.

• DOI: 10.7554/elife.78815
• 发表时间: 2022-11-23
• 期刊: eLife
• 影响因子: 7.7
• 作者: Szadai Z;Pi HJ;Chevy Q;Ócsai K;Albeanu DF;Chiovini B;Szalay G;Katona G;Kepecs A;Rózsa B
• 通讯作者: Rózsa B

Multiple modes of phase locking between sniffing and whisking during active exploration.

• DOI: 10.1523/jneurosci.3874-12.2013
• 发表时间: 2013-05-08
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Ranade S;Hangya B;Kepecs A
• 通讯作者: Kepecs A

Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback.

• DOI: 10.1016/j.cell.2015.07.057
• 发表时间: 2015-08-27
• 期刊: Cell
• 影响因子: 64.5
• 作者: Hangya B;Ranade SP;Lorenc M;Kepecs A
• 通讯作者: Kepecs A

Distinct behavioural and network correlates of two interneuron types in prefrontal cortex.

• DOI: 10.1038/nature12176
• 发表时间: 2013-06-20
• 期刊: Nature
• 影响因子: 64.8