Ending the HIV Epidemic in Rural America (EHE-RA): Local Interventions, Co-Epidemics, and Social Determinants

结束美国农村地区的艾滋病毒流行 (EHE-RA)：当地干预措施、共同流行病和社会决定因素

• 批准号: 10709638
• 负责人: Anthony Todd Fojo
• 金额: $ 48.26万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709638
• 关键词: AIDS prevention; Address; Affect; Alabama; Behavior; Calibration; Caring; Censuses; Centers for Disease Control and Prevention (U.S.); Cities; Continuity of Patient Care; Data; Disease remission; Disparity; Drug usage; Economic Models; Education; Enrollment; Epidemic; Ethnic Origin; Geographic Locations; Geography; Goals; HIV; HIV Infections; Harm Reduction; Health; Health Resources; Health Services Accessibility; Healthcare Systems; Home; Housing; Human immunodeficiency virus test; Incidence; Infection; Insurance; Insurance Coverage; Intervention; Link; Louisiana; Mississippi; Modeling; Opioid; Policies; Population; Poverty; Prevalence; Prevention; Preventive; Public Health; Race; Reporting; Resources; Rural; Rural Community; Services; Subgroup; Surveys; Taxes; Testing; U.S. Department of Housing and Urban Development; United States; Viral; Virus Diseases; Vulnerable Populations; design; epidemiological model; ethnic disparity; ethnic minority; evidence base; health care availability; health care service; housing instability; illicit opioid; improved; literature survey; mathematical model; medication for opioid use disorder; opioid epidemic; opioid misuse; opioid use; opioid use disorder; pre-exposure prophylaxis; prescription opioid; programs; racial disparity; racial minority; rural America; rural area; screening; sexual minority; social determinants; social health determinants; surveillance data; tool; transmission process; uptake; urban area; web-based tool

SUMMARY: Despite advances in treatment and prevention over the past decades, human immunodeficiency virus (HIV) imposes substantial burdens in the United States (US). US HIV infections are increasing concentrated in Southern states with a disproportionate number of rural infections, particularly among racial, ethnic, and sexual minorities. Rural epidemics in these states are linked to high-intensity urban epidemics, and driven by racial/ethnic disparities, poverty, inadequate insurance, limited access to healthcare, and housing insecurity. Additionally, the opioid epidemic disproportionately affects rural communities, increases HIV transmission, and hinders HIV control efforts. The Ending the HIV Epidemic (EHE) Initiative seeks to reduce HIV incidence by 90% over a decade. Ending the US HIV epidemic will require interventions tailored to local-level epidemic dynamics that address underlying drivers of transmission. Mathematical models of HIV transmission are powerful tool to forecast epidemics, and can provide evidence-based guidance on the optimal way to prioritize limited public health resources, but these models have focused primarily on urban epidemics. We have previously developed the Johns Hopkins Epidemiologic and Economic Model (JHEEM), a platform for modelling local HIV epidemics. Our objective is to generate projections of local HIV epidemics in states with a high rural burden of HIV to inform policy decisions by local health departments. We will partner health departments in three states where we have established relationships (Alabama, Louisiana, and Mississippi) to develop a suite of transmission models, based on JHEEM, that rigorously leverage local surveillance data to make projections of the HIV epidemic in each state. In Aim 1, we will develop an integrated, statewide modeling approach that links rural and urban regions using mobility data. We will use the models to identify which combinations of HIV testing, pre-exposure prophylaxis (PrEP), and viral suppression – targeted to which demographic subgroups and geographic regions – will yield the greatest reductions in incidence and disparities. In Aim 2, we will incorporate three social determinants of health: insurance, access to healthcare, and housing instability, and the racial and ethnic disparities in their distribution across the population. We will project the impact on HIV incidence and disparities of strategies that include both traditional HIV interventions and increase insurance, access to care, or stable housing. In Aim 3, we will expand JHEEM to include the opioid epidemic, and evaluate the potential reductions in HIV incidence achievable by strategies that combine harm reduction for opioid use disorder with HIV control interventions. These aims will yield a comprehensive modeling framework that links traditional HIV interventions with underlying drivers of the epidemic in rural America. Our results will provide data-driven projections, tailored to the specific needs of states, to inform effective deployment of public health resources in ending the HIV epidemic.

概括： 尽管过去几十年在治疗和预防方面取得了进展，但人类免疫缺陷病毒（HIV） 美国艾滋病毒感染日益集中在美国，造成巨大负担。 南部各州农村感染人数不成比例，特别是在种族、民族和性别方面 这些州的农村流行病与高强度的城市流行病有关，并由少数族裔推动。 种族/民族差异、贫困、保险不足、获得医疗保健的机会有限以及住房不安全。 此外，阿片类药物的流行对农村社区造成了不成比例的影响，增加了艾滋病毒的传播，并 阻碍艾滋病毒控制工作。 终结艾滋病毒流行 (EHE) 计划旨在在十年内将艾滋病毒发病率降低 90%。 美国艾滋病毒流行需要针对当地流行病动态采取干预措施，解决根本问题 传播的驱动因素。艾滋病毒传播的数学模型是预测流行病的有力工具，以及 可以提供基于证据的指导，以最佳方式优先考虑有限的公共卫生资源，但这些 我们之前开发了约翰·霍普金斯大学的模型，主要关注城市流行病。 流行病学和经济模型 (JHEEM)，一个对当地艾滋病毒流行进行建模的平台。 我们的目标是对农村艾滋病毒负担较高的州当地艾滋病毒流行情况进行预测，以提供信息 我们将与我们所在的三个州的卫生部门合作。 建立了关系（阿拉巴马州、路易斯安那州和密西西比州）来开发一套传输模型，基于 JHEEM 严格利用当地监测数据来预测每个州的艾滋病毒流行情况。 在目标 1 中，我们将开发一种综合的联邦建模方法，利用以下方法将农村和城市地区连接起来： 我们将使用这些模型来确定艾滋病毒检测和暴露前预防的组合。 （PrEP）和病毒抑制（针对人口亚群和地理区域）将产生效果 在目标 2 中，我们将纳入三个社会决定因素。 健康：保险、医疗保健、住房不稳定以及种族和民族差异 我们将预测对艾滋病毒发病率的影响以及采取的策略的差异。 在目标 3 中，包括传统的艾滋病毒干预措施和增加保险、获得护理或稳定的住房。 我们将扩大 JHEEM 以涵盖阿片类药物流行，并评估艾滋病毒发病率的潜在降低 可以通过将减少阿片类药物使用障碍危害与艾滋病毒控制干预措施相结合的策略来实现。 这些目标将产生一个全面的建模框架，将传统的艾滋病毒干预措施与潜在的艾滋病毒干预措施联系起来。 我们的研究结果将提供针对具体情况的数据驱动预测。 各国的需求，为有效部署公共卫生资源以结束艾滋病毒流行提供信息。