Translational Research in Alzheimer's Disease and related Dementias (TRADD)

阿尔茨海默病和相关痴呆症的转化研究 (TRADD)

• 批准号: 10709167
• 负责人: ROBERTA EILEEN BRINTON
• 金额: $ 29.45万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709167
• 关键词: Alzheimer' s disease related dementia; Translational Research

Project Summary/Abstract The University of Arizona (UArizona) Training Program to Advance Translational Research on Alzheimer's Disease and AD Related Dementias (AZ-TRADD) is designed to address knowledge and experience gaps in AD therapeutic discovery and preclinical translational development. To meet this challenge, the UArizona Translational Research in AD and related Dementias (AZ-TRADD) training program is designed as a problem based translational learning experience for predoctoral Ph.D and M.D./Ph.D fellows. In alignment with the 2021 NIH Alzheimer’s Research Summit: Path to Precision Medicine for Treatment and Prevention and the 2011 National Alzheimer’s Project Act (NAPA), the goal of the AZ-TRADD training program is to fill critical gaps that exist for AD translational research in academic graduate programs. To achieve this goal, the AZ-TRADD program will: 1) recruit trainees across multiple scientific disciplines; 2) employ problem-based learning approaches to solve challenges in AD therapeutic development with emerging tools and techniques; and 3) equip AZ-TRADD trainees with career development and leadership skills necessary to conduct team science and manage multidisciplinary teams. Through this approach, we ensure that AZ-TRADD trainees develop deep translational research expertise necessary for AD therapeutic development, while: 1) cultivating the ability to creatively and collaboratively solve problems working with experts across the translational landscape as part of large-scale team science; 2) gaining an applied understanding of how data science, particularly using data generated by AMP-AD, M2OVE-AD and ADNI, can accelerate translational research and provide avenues to novel therapeutic insights; 3) connecting geno- and phenotypic variations and multifaceted etiology of AD to therapeutic targets; and 4) gaining essential professional and business skills to navigate a diverse funding landscape and translate discoveries into the clinical setting. AZ-TRADD fellows will receive career mentoring and leadership development skills to manage multi-disciplinary teams in the 21st century that is Patient Inspired and Data Driven. The AZ- TRADD training program will develop a diverse, cross-disciplinary, and translationally oriented workforce to meet the critical challenge of creating a workforce capable of advancing therapeutics to prevent, delay, and treat AD and AD related dementias.

项目概要/摘要 亚利桑那大学 (UArizona) 推进阿尔茨海默病转化研究的培训计划 疾病和 AD 相关痴呆症 (AZ-TRADD) 旨在解决 AD 方面的知识和经验差距 治疗发现和临床前转化开发为了应对这一挑战，亚利桑那大学。 AD 和相关痴呆症转化研究 (AZ-TRADD) 培训计划是作为一个问题而设计的 为博士前博士和医学博士/博士研究员提供基于转化的学习经验，与 2021 年保持一致。 NIH 阿尔茨海默病研究峰会：治疗和预防的精准医学之路及 2011 年 根据国家阿尔茨海默病项目法案 (NAPA)，AZ-TRADD 培训计划的目标是填补以下关键空白： 为了实现这一目标，AZ-TRADD 项目存在于学术研究生项目中。 将：1）招募跨多个科学学科的学员；2）采用基于问题的学习方法 利用新兴工具和技术解决 AD 治疗开发中的挑战；3) 装备 AZ-TRADD 具有进行团队科学和管理所需的职业发展和领导技能的学员 通过这种方法，我们确保 AZ-TRADD 学员能够进行深度转化。 AD 治疗开发所需的研究专业知识，同时：1）培养创造性和 作为大规模项目的一部分，与整个翻译领域的专家合作解决问题 团队科学；2）获得对数据科学如何应用的理解，特别是如何使用数据科学 AMP-AD、M2OVE-AD 和 ADNI，可以加速转化研究并为新疗法提供途径 3) 将 AD 的基因和表型变异以及多方面病因学与治疗目标联系起来； 4) 获得必要的专业和商业技能，以驾驭多元化的融资环境并进行翻译 AZ-TRADD 研究员将获得职业指导和领导力发展。 管理 21 世纪以患者为灵感和数据驱动的多学科团队的技能。 TRADD 培训计划将培养一支多元化、跨学科、以翻译为导向的员工队伍，以满足 建立一支能够推进预防、延迟和治疗 AD 疗法的劳动力队伍是一项重大挑战 和 AD 相关的痴呆症。