Inflammatory mediators and beta-cell function among obese Latino youth with prediabetes

患有糖尿病前期的肥胖拉丁裔青年的炎症介质和 β 细胞功能

• 批准号: 10214563
• 负责人: Armando Pena
• 金额: $ 3.33万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-10 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10214563
• 关键词: Address; Adolescent; Adult; Affect; Age; Anti-Inflammatory Agents; Beta Cell; Cell physiology; Child; Chronic Disease; Communities; Data; Development; Diabetes prevention; Ensure; Environment; Equilibrium; Event; Fellowship; Fostering; Functional disorder; Funding; Future; Genetic Transcription; Goals; Individual; Inflammation; Inflammation Mediators; Inflammatory; Infrastructure; Interleukin-10; Interleukin-6; Knowledge; Latino; Link; Longitudinal Studies; Measurement; Measures; Mediator of activation protein; Mentors; Mentorship; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oral; Physical activity; Phytochemical; Postdoctoral Fellow; Prediabetes syndrome; Public Health; Research; Resources; Risk; Risk Reduction; Sampling; Science; Scientist; Secure; Societies; TNF gene; Testing; Underrepresented Populations; United States National Institutes of Health; Vulnerable Populations; Weight; Work; Youth; adiponectin; base; career; cytokine; diabetes risk; dietary; disorder prevention; fruits and vegetables; functional food; glucose tolerance; high risk; high risk population; impaired glucose tolerance; improved; indexing; inflammatory marker; inflammatory milieu; innovation; insulin sensitivity; lifestyle intervention; predictive marker; preservation; prevent; preventive intervention; public health priorities; public health relevance; response; treatment as usual; usual care arm

PROJECT SUMMARY Obesity and type 2 diabetes (T2D) disparities among Latino children and adolescents represent some of the most significant public health challenges facing society. Inflammation is associated with beta-cell dysfunction and both are evident in obese youth with prediabetes. Lifestyle intervention is the primary approach to preventing or delaying onset of T2D and has been effective in improving the inflammatory milieu and beta-cell function. However, less is known about the effect of lifestyle intervention on specific pro- and anti- inflammatory mediators associated with beta-cell dysfunction in youth. Furthermore, the relationship between changes in pro- and anti-inflammatory mediators and changes in beta-cell function remains unexplored in obese youth. Knowledge regarding the mechanisms by which T2D risk mediators are improved is limited due to a lack of measurement of different anti-inflammatory mediators. Therefore, we propose a longitudinal study that will examine the effect of lifestyle intervention on pro- and anti-inflammatory mediators in 79 obese Latino youth with prediabetes as compared to a usual care control group of 38 obesity- and glycemia-matched Latino youth. Understanding how changes in pro- and anti-inflammatory markers relate to changes in beta-cell function is important to identify specific mechanisms that can be targeted in future studies. Therefore, this study will explore the association between changes in pro- and anti-inflammatory mediators and changes in beta-cell function in obese Latino youth with prediabetes. This proposal leverages the resources and infrastructure of an ongoing diabetes prevention study and builds upon a transdisciplinary team of mentors to address a critical gap in chronic disease prevention in obese Latino youth, age 12-16 years. This innovative approach is an essential first step in the development of lifestyle interventions aimed at targeting inflammatory mechanisms to assess changes in T2D risk in this high-risk population.

项目概要 拉丁裔儿童和青少年之间的肥胖和 2 型糖尿病 (T2D) 差异代表了一些因素 社会面临的最重大的公共卫生挑战。炎症与β细胞有关 功能障碍，并且两者在患有糖尿病前期的肥胖青年中都很明显。生活方式干预是首要 预防或延缓 T2D 发病的方法，并可有效改善炎症环境 和β细胞功能。然而，人们对生活方式干预对特定亲和抗作用的影响知之甚少。 与青少年β细胞功能障碍相关的炎症介质。此外，之间的关系 促炎和抗炎介质的变化以及β细胞功能的变化仍未被探索 肥胖的青年。关于 T2D 风险中介改善机制的知识有限，因为 缺乏对不同抗炎介质的测量。因此，我们提出一项纵向研究 将检查生活方式干预对 79 名肥胖拉丁裔的促炎和抗炎介质的影响 患有前驱糖尿病的青少年与由 38 名肥胖和血糖匹配的拉丁裔组成的常规护理对照组进行比较 青年。了解促炎和抗炎标记物的变化如何与 β 细胞的变化相关 功能对于确定未来研究中可以针对的具体机制非常重要。因此，这 研究将探讨促炎介质和抗炎介质的变化与 患有糖尿病前期的肥胖拉丁裔青年的 β 细胞功能。该提案利用了资源和 正在进行的糖尿病预防研究的基础设施，并建立在跨学科的导师团队的基础上 解决 12-16 岁肥胖拉丁裔青少年慢性病预防方面的重大差距。这种创新的 该方法是制定旨在针对炎症的生活方式干预措施的重要第一步 评估该高危人群 T2D 风险变化的机制。

项目成果

Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity.

• DOI: 10.1002/oby.23279
• 发表时间: 2021-12
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Vander Wyst KB;Hu HH;Peña A;Olson ML;Bailey SS;Shaibi GQ
• 通讯作者: Shaibi GQ

Communicating incidental and reportable findings from research MRIs: considering factors beyond the findings in an underrepresented pediatric population.

• DOI: 10.1186/s12874-021-01459-8
• 发表时间: 2021-12-05
• 期刊: BMC medical research methodology
• 影响因子: 4
• 作者: Vander Wyst KB;Olson ML;Bailey SS;Valencia AM;Peña A;Miller J;Shub M;Seabrooke L;Pimentel J;Olsen K;Rosenberg RB;Shaibi GQ
• 通讯作者: Shaibi GQ

Organ fat in Latino youth at risk for type 2 diabetes.

• DOI: 10.1111/pedi.13311
• 发表时间: 2022-05
• 期刊: Pediatric diabetes
• 影响因子: 3.4
• 作者: Pimentel JL;Vander Wyst KB;Soltero EG;Peña A;Hu HH;Bailey SS;Pokorney A;Ayers SL;Valencia AM;Olson ML;Shaibi GQ
• 通讯作者: Shaibi GQ

Inflammatory Mediators and Type 2 Diabetes Risk Factors before and in Response to Lifestyle Intervention among Latino Adolescents with Obesity.

• DOI: 10.3390/nu15112442
• 发表时间: 2023-05-24
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Peña A;Olson ML;Ayers SL;Sears DD;Vega-López S;Colburn AT;Shaibi GQ
• 通讯作者: Shaibi GQ