Exercise and Fitness in Childhood Cancer Survivors

儿童癌症幸存者的锻炼和健身

• 批准号: 6765008
• 负责人: Debra L. Friedman
• 金额: $ 11.74万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6765008
• 关键词: acute lymphocytic leukemia; adolescence (12-20); aerobic exercise; behavioral /social science research tag; central nervous system neoplasms; clinical research; fatigue; health education; human morbidity; human subject; long term survivor; lymphoma; metabolic syndrome; neoplasm /cancer education; obesity; outcomes research; pediatric neoplasm /cancer; photon absorptiometry; physical fitness; psychological adaptation; psychological aspect of cancer; quality of life; questionnaires; sarcoma; social psychology; therapy adverse effect

DESCRIPTION (provided by applicant) This proposal is submitted in response to RFA CA-04-03 by a new investigator. It outlines pilot research (R21) to evaluate a physical exercise intervention to improve young childhood cancer survivors' physical fitness and involvement in physical activity. The team of researchers assembled for this study will contribute exceptional expertise in pediatric psycho-oncology, pediatric oncology, pediatric endocrinology and fitness exercise in oncology patients. We hypothesize that the physical exercise program, offered as an intervention to young survivors of childhood cancer, will positively affect their physical and psychological adjustment to their disease and its treatment. Subjects who receive the intervention and health and fitness education will be more likely to experience better physical functioning and more improved quality of life than those enrolled in a control group who receive health and fitness education alone. It is anticipated that the intervention will produce positive changes in several of the long-term morbidities associated with childhood cancer, including physical deconditioning, obesity, fatigue, related metabolic conditions and problems in psychological adjustment. The study utilizes a randomized, between groups, repeated measures design, with an Intervention Condition (IC) and a Control Condition (CC). 40 young survivors of childhood cancer, 5+ years from their diagnosis will be recruited. 20 subjects will be randomly assigned to either the IC or the CC. Subjects assigned to the IC will receive a 12-week long aerobic exercise and physical activity program, coupled with health and fitness education. CC subjects will receive only the health and fitness education. Primary outcomes of physical exercise capacity (VO2max), involvement in physical activity and health-related quality of life will be assessed at baseline, end of therapy, and at 3 months after the end of therapy. A number of secondary outcomes including indices of metablolic function, body mass/composition, and psychological adjustment will also be obtained. Data from this study will be instrumental in development of a more definitive, large-scale study of this important issue. Ultimately, this research will provide vital information regarding the long-term physical sequelae of childhood cancer, and will direct interventions to mitigate these outcomes and enhance quality of life.

描述（由申请人提供） 该提案是由一位新研究者响应 RFA CA-04-03 提交的。它概述了试点研究（R21），以评估体育锻炼干预措施，以改善幼儿癌症幸存者的身体健康和参与体育活动。为这项研究组建的研究人员团队将在儿科心理肿瘤学、儿科肿瘤学、儿科内分泌学和肿瘤患者的健身运动方面贡献卓越的专业知识。我们假设，作为对儿童癌症年轻幸存者的干预措施提供的体育锻炼计划将积极影响他们对疾病及其治疗的身体和心理调整。与仅接受健康和健身教育的对照组相比，接受干预和健康和健身教育的受试者更有可能体验到更好的身体机能和更高的生活质量。预计干预措施将对与儿童癌症相关的几种长期发病产生积极的变化，包括身体机能失调、肥胖、疲劳、相关代谢状况和心理调节问题。 该研究采用随机、组间重复测量设计，具有干预条件 (IC) 和控制条件 (CC)。将招募 40 名儿童癌症幸存者，他们的诊断时间已超过 5 年。 20 名受试者将被随机分配到 IC 或 CC。分配到 IC 的受试者将接受为期 12 周的有氧运动和体育活动计划，以及健康和健身教育。 CC 受试者将仅接受健康和健身教育。将在基线、治疗结束以及治疗结束后 3 个月时评估身体锻炼能力 (VO2max)、身体活动参与度和健康相关生活质量的主要结果。还将获得许多次要结果，包括代谢功能、体重/成分和心理调整指数。这项研究的数据将有助于对这一重要问题进行更明确、更大规模的研究。最终，这项研究将提供有关儿童癌症长期身体后遗症的重要信息，并将指导干预措施以减轻这些后果并提高生活质量。