Predicting individual risk of cognitive decline in women

预测女性认知能力下降的个体风险

• 批准号: 6683757
• 负责人: JENNIFER L ETNIER
• 金额: $ 7.48万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6683757
• 关键词: Alzheimer's disease; aerobic exercise; aging; apolipoprotein E; body physical activity; clinical research; cognition; cognition disorders; community; disease /disorder proneness /risk; female; genotype; human middle age (35-64); human old age (65+); human subject; mental health epidemiology

19. Genetics, Behavior and Aging. The epsilon 4 allele of apolipoprotein E (ApoE-e4) has been identified as a genetic risk factor for cognitive impairment, cognitive decline, and the experience of Alzheimer's Disease (AD). However, the presence of ApoE-e4 does not guarantee these cognitive outcomes. Therefore, one important direction for future research is to identify variables that may interact with ApoE genotype to determine cognitive outcomes. Physical activity is a behavioral variable that may play a role in the expression of the ApoE genotype relative to cognition. Physical activity has been shown to be associated with better cognitive abilities and with lessened cognitive decline with age. Further, the effects of physical activity on cognition have been shown in men to be moderated by ApoE genotype. Thus, the primary purpose of the proposed study is to add to the extant literature by testing the interactive effects of physical activity and ApoE genotype on the cognitive performance of a sample of older women. The literature will also be extended by assessing aerobic fitness which will provide insight into the causal mechanisms which may underlie the relationships being tested. Community-dwelling older women (50-80 years) who have a family history of AD will be recruited. Participants will perform a battery of cognitive tests, will have their blood drawn to determine their ApoE genotype, will complete a physical activity questionnaire, and will perform a maximal aerobic fitness test. It is hypothesized that the beneficial effects of physical activity and aerobic fitness on cognitive performance will be moderated by the presence of the ApoE-4 allele. Regression analyses will be used to test these effects. This study will advance our knowledge about the behavioral variables that modify genetic risk for cognitive impairment in older women. ApoE-4 is well established as a risk factor for cognitive decline and for the experience of AD. However, behavioral variables such as physical activity may impact the expression of this genetic risk factor and this study will extend our knowledge regarding this relationship. Additionally, the findings of this study will have important implications for identifying participants for whom physical activity may be especially beneficial with regards to cognition.

19. 遗传学、行为和衰老。载脂蛋白 E (ApoE-e4) 的 epsilon 4 等位基因已被确定为认知障碍、认知能力下降和阿尔茨海默病 (AD) 的遗传风险因素。然而，ApoE-e4 的存在并不能保证这些认知结果。因此，未来研究的一个重要方向是识别可能与 ApoE 基因型相互作用的变量，以确定认知结果。体力活动是一种行为变量，可能在 ApoE 基因型相对于认知的表达中发挥作用。身体活动已被证明与更好的认知能力以及随着年龄增长而减少的认知能力下降有关。此外，ApoE 基因型可以调节男性体力活动对认知的影响。因此，该项目的主要目的是 拟议的研究旨在通过测试体力活动和 ApoE 基因型对老年女性样本认知表现的相互作用影响，对现有文献进行补充。文献还将通过评估有氧健身来扩展，这将提供对可能构成正在测试的关系的因果机制的深入了解。将招募有 AD 家族史的社区老年妇女（50-80 岁）。参与者将进行一系列认知测试，抽血以确定他们的 ApoE 基因型，完成体力活动调查问卷，并进行最大有氧健身测试。据推测，体力活动和有氧健身对认知能力的有益影响将因 ApoE-4 等位基因的存在而减弱。回归分析将用于测试这些影响。这项研究将增进我们对改变老年女性认知障碍遗传风险的行为变量的认识。 ApoE-4 已被确定为认知能力下降和 AD 经历的危险因素。然而，身体活动等行为变量可能会影响这种遗传风险因素的表达，这项研究将扩展我们对这种关系的认识。此外，这项研究的结果对于确定体育活动可能对认知特别有益的参与者具有重要意义。