Linking Brain and Behavior in Chronic Tic Disorders

将慢性抽动障碍的大脑和行为联系起来

基本信息

批准号：
9279280
负责人：
Sandra K Loo
金额：
$ 33.74万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9279280
关键词：
12 year old Address Age Area Attention Base of the Brain Behavior Therapy Behavioral Biological Markers Biological Neural Networks Blinking Body Image Brain Characteristics Child Childhood Chronic Clinical Comorbidity Complex Control Groups Corpus striatum structure Data Development Diagnosis Diagnostic Effectiveness Electroencephalography Electromyography Etiology Event Exhibits Frequencies Functional disorder Generations Gilles de la Tourette syndrome Habits Heterogeneity Impulsivity Individual Inferior frontal gyrus Intervention Involuntary Movements Link Literature Magnetic Resonance Imaging Medial Mediating Methods Modeling Morphologic artifacts Motion Motor Movement Muscle Neurobiology Neurodevelopmental Disorder Parietal Parietal Lobe Patient Self-Report Pharmaceutical Preparations Phase Production Quality of life Research Resolution Role Sample Size Sampling Severities Source System Technology Testing Tic disorder Training Youth aged base brain behavior developmental disease directed attention frontal lobe imaging approach imaging modality imaging study improved innovation millisecond neural circuit neural model neurobiological mechanism neuromechanism neuroregulation novel novel strategies peer relating to nervous system temporal measurement

项目摘要

Abstract The neural circuitry underlying premonitory urge and tic suppression is particularly important given the role of voluntary tic control in improved quality of life and enhanced effectiveness of empirically supported behavioral treatments such as Habit Reversal Training (HRT) for individuals with Chronic Tic Disorders (CTDs), including those with Tourette's Syndrome. Despite a building research base, the etiology and pathophysiology of CTDs remain poorly understood, with existing findings confounded by small sample sizes, developmental effects due to wide age range, medication usage, and uncontrolled psychiatric comorbidity. In the current project, we propose to apply an innovative approach (mobile brain/body imaging [MoBI] to characterizing the neural substrates underlying premonitory urge and tic suppression in CTDs. The MoBI approach involves the simultaneous recording and integration of high-definition motion capture video, cortical activity (electroencephalography; EEG) and muscle movements (electromyography; EMG). Use of this leading edge technology will advance our understanding of the neural substrates underlying urge suppression and may allow identification of putative biomarkers for premonitory urge and tic suppression. The current study proposes to use the MoBI approach on a sample of 175 children aged 8-12 years old, 125 with CTDs and 50 age-matched healthy control (HC) peers. We will use several paradigms to model the neural substrates underlying voluntary and involuntary movements and test whether CTDs involve quantitative or qualitative deviation in motor network circuitry relative to HC peers. Successful application of the MoBI approach to the problem of discovering and testing brain-based biomarkers for CTD is highly innovative in the context of current research, and also has clear potential for advancing clinical CTD research and practice.

抽象的考虑到前兆冲动和抽动抑制的神经回路尤其重要自愿抽动控制在改善生活质量和增强经验支持的有效性方面的作用针对慢性抽动障碍患者的行为治疗，例如习惯逆转训练 (HRT) (CTD)，包括抽动秽语综合症患者。尽管研究基地正在建设中，但病因学和 CTD 的病理生理学仍然知之甚少，现有研究结果因样本量小而混乱，由于年龄范围广、药物使用和不受控制的精神共病而对发育产生影响。在在当前的项目中，我们建议应用一种创新方法（移动大脑/身体成像 [MoBI] 表征 CTD 中预兆冲动和抽动抑制的神经基质。移动终端该方法涉及同时记录和集成高清动作捕捉视频、皮质活动（脑电图；EEG）和肌肉运动（肌电图；EMG）。利用这一领先边缘技术将增进我们对冲动抑制背后的神经基质的理解，并可能允许识别预兆冲动和抽动抑制的假定生物标志物。目前的研究建议对 175 名 8-12 岁儿童样本使用 MoBI 方法，其中 125 名患有 CTD，50 名儿童年龄匹配的健康对照（HC）同龄人。我们将使用几种范例来模拟神经基质潜在的自愿和非自愿运动并测试 CTD 是否涉及定量或定性电机网络电路相对于 HC 同行的偏差。 MoBI方法的成功应用发现和测试基于大脑的 CTD 生物标志物的问题在以下背景下具有高度创新性：目前的研究，并且在推进临床 CTD 研究和实践方面也具有明显的潜力。