University of Kentucky Center for Cancer and Metabolism

肯塔基大学癌症与代谢中心

• 批准号: 9211863
• 负责人: DARET K ST CLAIR
• 金额: $ 222.02万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9211863
• 关键词: Address; Apoptosis; Area; Attention; Basic Science; Biochemistry; Bioinformatics; Biological Markers; Biology; Biometry; Cancer Center; Cancer Death Rates; Cancer Patient; Cell Cycle; Cell Proliferation; Cell Survival; Centers of Research Excellence; Clinical; Collaborations; Core Facility; Coupled; Data; Data Science; Development; Discipline; Early Diagnosis; Environment; Event; Faculty; Fostering; Foundations; Funding; Future Generations; Goals; Grant; Growth; Image; Incidence; Interdisciplinary Study; Intervention; Investigation; Kentucky; Lead; Link; Location; Malignant Neoplasms; Mediator of activation protein; Mentors; Metabolic; Metabolic Diseases; Metabolism; Neoplasm Metastasis; Obesity; Outcome; Oxidation-Reduction; Pilot Projects; Proliferating; Quality of life; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Role; Scientist; Seeds; Signal Transduction; System; Therapeutic; Training; Translations; United States National Institutes of Health; Universities; anticancer research; base; cancer cell; cancer imaging; cancer initiation; cancer therapy; career; cohesion; defined contribution; design; imaging capabilities; improved; innovation; insight; interdisciplinary approach; metabolomics; mortality; multidisciplinary; novel; novel therapeutics; prevent; programs; skills; success; synergism; therapeutic target; therapy outcome; tool; trait; tumor metabolism; tumor microenvironment; tumor progression; tumorigenesis

PROJECT SUMMARY Cancer cell survival traits such as suppressed apoptosis, rapid cell cycling and proliferation and the ability to metastasize from a primary location require extensive metabolic reprogramming of the tumor microenvironment. Intriguing new insights into the novel role of metabolic dysregulation in tumorigenesis and metastasis increasingly draw attention to currently understudied areas of cancer research: the potential for metabolic modulation to influence therapeutic outcomes and the impact of metabolic events at the clinical level to impact quality of life for cancer patients. The University of Kentucky (UK) proposes to establish a unique multidisciplinary Center of Biomedical Research Excellence (COBRE) on Cancer and Metabolism (CCM) as a strategically designed, sustainable framework that cultivates cutting-edge research focused on the role of metabolic mediators of cancer development and progression. The proposed multidisciplinary center leverages highly specialized expertise in redox biology, cancer cell signaling, systems biochemistry and data sciences as well as the presence of advanced metabolomics and sophisticated cancer imaging capabilities to create an integrated cancer-metabolism research framework. Overarching goals are to strengthen UK's cancer research enterprise by providing a thematically focused multidisciplinary infrastructure dedicated to defining the contribution of metabolism in the development and treatment of cancer and to use this novel multidisciplinary platform to develop promising early-stage investigators with enhanced skills in an exciting new area of cancer research. To accomplish these goals, we will (1) develop a critical mass of funded investigators with research programs directly related to the Center's unifying theme, (2) provide strong team-based mentoring combining basic and clinical expertise, (3) recruit new investigators to the Center through pilot project grant support leveraged by institutional funds, (4) create synergy among research projects via critical links to strong research centers at UK, including existing COBREs, and (5) facilitate the translation of basic findings in cancer metabolism into early therapeutic approaches. Proposed new synergies will be developed through four research projects, an Administrative Core, important research cores in metabolism and imaging and strong biostatistics/ bioinformatics support, all of which are critical to the proposed studies and will contribute to the development of institutional resources. The scientific focus of the four research projects is cancer-metabolism interactions spanning basic and translational perspectives. This concentration of multidisciplinary expertise focused on a newly recognized cancer paradigm holds promise for significant new understandings of oncogenesis overall. The CCM's integrative thematic focus and the clinical and translational implications of innovative understandings of the cancer-metabolism axis have strong potential to create a cadre of well-trained scientists who are well equipped to lead future generations of scientists integrating these exciting new avenues of investigation in metabolic dysregulation into multi-faceted studies on cancer development and therapy.

项目摘要 癌细胞的存活特征，例如抑制凋亡，快速细胞循环和增殖以及能力 从主要位置转移需要大量的肿瘤代谢重编程 微环境。有趣的新见解是代谢失调在肿瘤发生和 转移越来越多地注意当前研究的癌症研究领域： 代谢调节以影响治疗结果和代谢事件在临床水平上的影响 影响癌症患者的生活质量。肯塔基大学（英国）提议建立一个独特的 卓越生物医学研究中心（COBRE）关于癌症和代谢的cobre（CCM） 战略设计，可持续的框架，培养了尖端研究，重点是 癌症发展和进展的代谢介体。拟议的多学科中心利用 氧化还原生物学，癌细胞信号，系统生物化学和数据科学方面的高度专业化专业知识 以及高级代谢组学和复杂的癌症成像能力的存在，以创建一个 综合癌症代谢研究框架。总体目标是加强英国的癌症研究 通过提供主题集中的多学科基础架构来定义企业 新陈代谢在癌症的发展和治疗中的贡献，并使用这种新颖的多学科 在令人兴奋的新的癌症领域中发展有前途的早期调查员的平台，以提高技能 研究。为了实现这些目标，我们将（1）开发一大批资助的研究人员 与中心统一主题直接相关的程序，（2）提供强大的基于团队的指导组合 基本和临床专业知识，（3）通过试点项目赠款支持将新调查人员招募到中心 （4）通过与强大研究的关键链接在研究项目之间建立协同作用（4） 英国的中心，包括现有的小鸡，（5）促进癌症基本发现的翻译 代谢为早期的治疗方法。拟议的新协同作用将通过四个 研究项目，一种行政核心，代谢和成像中的重要研究核心 生物统计学/生物信息学支持，所有这些对拟议的研究至关重要，并将为 制度资源的发展。这四个研究项目的科学重点是癌症代谢 相互作用涵盖基本和翻译观点。多学科专业知识的集中 专注于新认可的癌症范式有望对 总体上发生肿瘤。 CCM的综合主题重点以及临床和翻译的含义 对癌症代谢轴的创新理解具有创建训练有素的干部的强大潜力 能够领导子孙后代的科学家，将这些令人兴奋的新途径融合在一起的科学家 对癌症发育和治疗多面研究的代谢失调研究的研究。