A Self-Monitoring Artificial Vascular Graft

自我监控人工血管移植物

• 批准号: 6647378
• 负责人: David Vilkomerson
• 金额: $ 9.98万
• 依托单位: DVX, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647378
• 关键词: artificial membranes; bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomedical device power system; biomedical equipment development; blood vessel prosthesis; patient monitoring device; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): Development of a self-monitoring graft is the long term goal of this project. Such a graft, rather than being a passive conduit for blood, would measure the blood flowing through it and, if the flow approached levels at which the graft might thrombose, communicate the need for treatment directly to the physician. At present, 60,000 artificial by-pass leg grafts per year are implanted in the USA. Most fail within three years,leading to amputation. By making such grafts "smart grafts" that communicate impending failure, many of these limbs should be saved. Special ultrasound transducers have been developed that can be embedded in the walls of the graft and measure the blood flow passing through the graft. The proposed Phase I work would demonstrate the feasibility of the smart graft by constructing an operating graft with flow-sensing capability, and by analysis show that the associated circuitry and power source could be implanted with 5 year or more life. The Phase II continuation of the program would undertake the fabrication and implantation of prototype smart grafts.

描述（由申请人提供）： 开发自我监测移植物是该项目的长期目标。这种移植物不是被动的血液导管，而是测量流过它的血液，如果血流达到移植物可能形成血栓的水平，则直接向医生传达治疗的需要。目前，美国每年植入 60,000 例人工搭桥腿移植物。大多数在三年内失败，导致截肢。通过使此类移植物成为“智能移植物”来传达即将发生的故障，许多肢体应该可以被挽救。已经开发出特殊的超声换能器，可以嵌入移植物的壁中并测量通过移植物的血流量。拟议的第一阶段工作将通过构建具有流量传感功能的操作移植物来证明智能移植物的可行性，并通过分析表明相关电路和电源的植入寿命可达 5 年或更长。该计划的第二阶段延续将进行智能移植物原型的制造和植入。

项目成果

Finding the peak velocity in a flow from its Doppler spectrum.

从多普勒频谱中查找流中的峰值速度。

• 发表时间: 2013-10
• 作者: Vilkomerson, David;Ricci, Stefano;Tortoli, Piero
• 通讯作者: Tortoli, Piero

Accurate blood peak velocity estimation using spectral models and vector doppler.

使用频谱模型和矢量多普勒精确估计血液峰值速度。

• 发表时间: 2015-04
• 作者: Ricci, Stefano;Vilkomerson, David;Matera, Riccardo;Tortoli, Piero
• 通讯作者: Tortoli, Piero