RR&D Research Career Scientist Award Application

RR

• 批准号: 9394573
• 负责人: JANIS J. DALY
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9394573
• 关键词: Accounting; Admission activity; Affect; Age; Aging; Area; Automobile Driving; Award; Biological Neural Networks; Biomechanics; Biomedical Engineering; Biophysics; Brain; Caring; Chemicals; Chronic; Clinical; Clinical Protocols; Cognitive; Collaborations; Development; Disabled Persons; Discipline; Electrical Engineering; Emotions; Environment; Equilibrium; Exercise; Exercise Physiology; Experimental Psychology; Florida; Funding; Funding Opportunities; Gait; Goals; Growth; Hand functions; Health; Healthcare; Healthcare Systems; Hospitals; Impairment; Individual; Injury; Institution; Intervention; Laboratories; Leadership; Life; Link; Measurement; Mentors; Methods; Mission; Motor; Multiple Sclerosis; Nervous System Trauma; Neurologist; Neurology; Neuronal Dysfunction; Neuronal Plasticity; Neurophysiology - biologic function; Neuropsychology; Neurosciences; Occupational Therapist; Occupational Therapy; Parkinson Disease; Pathology; Pattern; Performance; Physical therapy; Physics; Physiology; Pilot Projects; Population; Positioning Attribute; Productivity; Protocols documentation; Quality of life; Rehabilitation Centers; Rehabilitation Research; Rehabilitation therapy; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Role; Scientist; Senior Scientist; Services; Societies; Spinal cord injury; Strategic Planning; Stroke; Talents; Testing; Training; Traumatic Brain Injury; Treatment Protocols; Universities; Upper Extremity; Veterans; Vision; arm; career; cognitive control; cost; disability; effective intervention; empowered; experience; fitness; improved; innovation; motor control; motor function recovery; motor learning; motor recovery; nervous system disorder; neuromuscular; neuroregulation; novel; physical therapist; prevent; programs; research and development; statistics; stroke survivor

Problem. Neurological disease and injury are major causes of disability, reflecting the need for more effective interventions. Additionally, accounting for the aging Veteran population, there is a projected 20% increase in disability for individuals age 85 and older, within the next 10 years. For example, approximately 6,000 VA annual admissions are for stroke, and at least 50% have serious, long term disability. Equally compelling statistics exist for traumatic brain injury (TBI) and other neurological diseases and injury. Research Activities and Overarching Goals. In strong support of the VHA Vision 2020 Strategic Plan and the RR&D mission, Dr. Daly is Director of the VA BRRC, whose mission is as follows: Discover mechanisms of pathology and impairment presenting obstacles to neural function, and generate innovative treatments to potentiate neural plasticity and neural network reorganization that will substantially improve motor, cognitive, and emotion function affected by neurologic disease or injury, sufficient to enhance quality of life and return to society and life role participation. To that end, Dr. Daly’s empowering BRRC leadership has attracted an interdisciplinary critical mass of electrical and biomedical engineers, biomechanists, neurologists, physical and occupational therapists, experimental and clinical neuropsychologists, exercise and neuromuscular physiologists, neuroscientists, and chemical and biophysicists. Significant discoveries have included information regarding the pathologies underlying neural dysfunction and innovative methods for restoring neural control of motor, cognitive, and emotion function for those with TBI, stroke, Parkinson’s disease, spinal cord injury, and multiple sclerosis. Supporting the VHA Mission and goals, and in addition to her BRRC leadership, Dr. Daly directs the Cognitive and Motor Learning Research Program, whose mission is to identify, engage, and restore the neural control that drives recovery of motor function in stroke survivors. Goals of currently ongoing studies are as follows: 1. Identify brain pattern changes that drive motor recovery. 2. Generate novel treatment methods that more accurately target pathology and impairment. 3. Apply motor learning principles that engage brain plasticity mechanisms allowing for productive practice of progressively more normal coordinated gait and upper limb function. 4. Generate and test treatment modules for gait components and upper limb function components. 5. Test gait and upper limb coordination treatment protocols in the clinical environment. Discoveries include the following: development and successful testing of a gait coordination training protocol that is clinically and statistically effective in chronic moderately impaired stroke survivors; successful feasibility pilot testing of a unique two-year care program for gait coordination, mobility, and fitness in stroke survivors; brain activation changes identified that drive upper limb motor recovery; development and successful testing of an upper limb function training protocol that is clinically and statistically effective in chronic moderately/severely impaired stroke survivors; necessary essential content of coordination training protocols includes long-duration, intensive coordination practice of finely incremental progression through a difficulty hierarchy.

问题是神经系统疾病和损伤是导致残疾的主要原因，这反映出需要更多的帮助。 此外，考虑到退伍军人人口老龄化，预计有 20%。 未来 10 年内，85 岁及以上老年人的残疾率将增加。 退伍军人管理局每年有 6,000 名患者因中风入院，其中至少 50% 患有严重的长期残疾。 关于创伤性脑损伤 (TBI) 和其他神经系统疾病和损伤，存在令人信服的统计数据。 研究活动和总体目标 大力支持 VHA 2020 年愿景战略。 计划和 RR&D 任务，Daly 博士是 VA BRRC 主​​任，其任务如下：发现 病理和损伤机制对神经功能造成障碍，并产生创新 增强神经可塑性和神经网络重组的治疗将显着改善 受神经系统疾病或损伤影响的运动、认知和情感功能，足以提高 为此，Daly 博士的 BRRC 领导力赋予了我们权力。 吸引了一批跨学科的电气和生物医学工程师、生物力学学家、神经学家、 物理和职业治疗师、实验和临床神经心理学家、运动和 神经肌肉生理学家、神经科学家以及化学和生物物理学家取得了重大发现。 包括有关神经功能障碍的病理学和创新方法的信息 恢复 TBI、中风、帕金森病患者的运动、认知和情感功能的神经控制 疾病、脊髓损伤和多发性硬化症。 Daly 博士支持 VHA 的使命和目标，除了领导 BRRC 之外，还指导 认知和运动学习研究计划，其使命是识别、参与和恢复神经 驱动中风幸存者运动功能恢复的控制。 目前正在进行的研究目标如下： 1. 识别促进运动恢复的大脑模式变化。 2. 产生更准确地针对病理和损伤的新型治疗方法。 3. 应用运动学习原理，利用大脑可塑性机制进行富有成效的实践 步态和上肢功能的协调性逐渐变得更加正常。 4. 生成并测试步态组件和上肢功能组件的治疗模块。 5. 在临床环境中测试步态和上肢协调治疗方案。 发现包括以下内容： 步态协调训练的开发和成功测试 对慢性中度受损中风幸存者具有临床和统计学效果的方案是成功的； 对独特的两年护理计划进行可行性试点测试，以促进中风患者的步态协调、活动能力和健康 幸存者；发现大脑激活变化可促进上肢运动的恢复和成功； 测试在慢性病中临床和理论上有效的上肢功能训练方案 中度/重度受损的中风幸存者；协调训练方案的必要基本内容； 包括通过难度进行精细渐进式进展的长期、密集协调练习 等级制度。