MRI-Guided Irreversible Electroporation Ablation for Liver Tumors

MRI 引导不可逆电穿孔消融治疗肝脏肿瘤

基本信息

批准号：
9314545
负责人：
Zhuoli Zhang
金额：
$ 34.72万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9314545
关键词：
Ablation Address Advocate Biomedical Engineering Blood Vessels Cell Death Cell Membrane Permeability Cell membrane Clinical Common Neoplasm Contrast Media Diffusion Discrimination Early Diagnosis Early identification Electrical Engineering Electrodes Electroporation Elements Gadolinium DTPA Goals Heating Image Injection of therapeutic agent Intervention Lead Lesion Liver Liver neoplasms Magnetic Resonance Imaging Maps Measurement Measures Methods Modeling Molecular Weight Monitor Normal tissue morphology Oryctolagus cuniculus Outcome Patient-Focused Outcomes Patients Peripheral Physiologic pulse Planning Techniques Primary carcinoma of the liver cells Procedures Property Relaxation Spatial Distribution Technology Therapeutic Thermal Ablation Therapy Tissues Treatment Protocols Tumor Tissue Ultrasonography Unresectable X-Ray Computed Tomography base extracellular follow-up image guided imaging modality in vivo individual patient intrahepatic liver tumor ablation oncology pre-clinical predictive of treatment response public health relevance response targeted delivery targeted imaging tumor uptake

项目摘要

DESCRIPTION (provided by applicant): Irreversible electroporation (IRE) is a powerful new ablation technology that overcomes many of the primary limitations of thermal ablation approaches. However, for accurate, early prediction of treatment response, follow-up imaging methods must permit in vivo discrimination of irreversibly electroporated tissues from adjacent inadequately treated, reversibly electroporated tissues. Our most recent studies have demonstrated that quantitative MRI methods can detect electroporation-induced alterations to the cell membrane in both tumor and normal tissues. We will develop a powerful new MRI-guided IRE approach permitting a) pre- procedural planning to predict IRE ablation volumes, b) intra-procedural monitoring of tissue response and c) early post-procedural identification of inadequately treated (reversibly electroporated) tissues. Our ultimate goal is to achieve complete treatment of targeted tumors while avoiding excessive damage to adjacent liver tissues. The proposed pre-clinical project will address the following Specific Aims in a well-established rabbit liver tumor model: Specific Aim 1: To develop pre-procedural planning techniques to more accurately predict IRE ablation volumes. Specific Aim 2: To develop intra-procedural imaging methods for immediate functional monitoring of tumor tissue response. Specific Aim 3: To develop post-procedural imaging methods for early identification of inadequately treated, reversibly electroporated tumor tissues.

描述（由适用提供）：不可逆的电穿孔（IRE）是一种强大的新消融技术，它克服了热消融方法的许多主要局限性。但是，为了准确，早期预测治疗反应，后续成像方法必须允许从相邻不充分处理，可逆的电穿孔组织中对不可逆的电穿孔组织进行体内歧视。我们最近的研究表明，定量MRI方法可以检测到肿瘤和正常组织中电穿孔引起的细胞膜改变。我们将开发一种强大的新MRI引导方法，允许a）术前计划，以预测烧蚀量，b）对组织反应的术中监测和c）早期对不充分处理（可逆的电穿孔）组织的早期术后鉴定。我们的最终目标是实现靶向肿瘤的完整治疗，同时避免过度损害相邻的肝尖端。拟议的临床前项目将在建立良好的兔子肝肿瘤模型中解决以下特定目标：特定目的1：开发前心理计划技术以更准确地预测IRE的消融量。特定目的2：开发核内成像方法，以立即对肿瘤组织反应进行功能监测。特定目的3：开发后期化学成像方法，以尽早鉴定经过不充分处理的，可逆的电穿孔组织。