2017 Stress Proteins in Growth, Development and Disease GRC/GRS: Maintaining proteostasis over a lifetime.

2017 生长、发育和疾病中的应激蛋白 GRC/GRS：一生中维持蛋白质稳态。

基本信息

批准号：
9389763
负责人：
KEVIN ANTHONY MORANO
金额：
$ 1.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9389763
关键词：
Address Aging Alzheimer&apos s Disease Area Attention Biological Models Biology Biomedical Research Biophysics Cardiovascular Diseases Cattle Cell Aging Cell Proliferation Cellular Stress Cellular biology Collaborations Country Creutzfeldt-Jakob Syndrome Defect Development Diabetes Mellitus Disease Ensure Environment Epigenetic Process Europe Evaluation Gene Activation Gene Expression Gene Expression Regulation Gene Mutation Generations Genes Genetic Transcription Germany Goals Growth and Development function Health Heat shock proteins Human Huntington Disease Inherited Intervention Investigation Link Liver diseases Longevity Maine Maintenance Malignant Neoplasms Metabolic Diseases Metabolism Modality Molecular Chaperones Neurodegenerative Disorders Oral Organism Oxidative Stress Parkinson Disease Participant Pharmacology Physiological Physiology Play Postdoctoral Fellow Protein Biosynthesis Proteins Proteome Quality Control Radiation induced damage Regulation Request for Applications Research Research Personnel Resort Ribosomes Rivers Role Science Scientist Series Signal Transduction Site Stress Structure Students System Techniques Temperature Time Training Underrepresented Minority Universities Woman Work biological adaptation to stress career career development collaborative environment combat gene product graduate student human disease innovation medical schools meetings polyglutamine polypeptide posters prevent prion-based programs protein aggregation protein degradation protein folding protein function protein misfolding proteostasis proteotoxicity response stress protein success symposium

项目摘要

PROJECT SUMMARY The cellular proteome is constantly exposed to a wide variety of proteotoxic stress conditions over a lifetime. These include external stresses, such as elevated temperatures and radiation damage as well as physiological stresses encountered during cellular proliferation and differentiation, such as oxidative stress, or challenges to protein folding caused by inherited gene mutations. A hallmark of stressed cells and organisms is the deployment of a comprehensive stress response essential for the maintenance of protein homeostasis that includes increased synthesis of molecular chaperones that aid in the folding of nascent polypeptides and prevent protein misfolding and aggregation. The protein quality control and stress protection machineries require strict signaling modalities and transcriptional programs, many of which are altered in a number of disease states, including cancer, cardiovascular disease, metabolic disease (e.g., diabetes) and liver disease. Modulation of the stress response also plays a critical role in life-span regulation and aging- related disorders such as Alzheimer's, Parkinson's, Huntington's diseases as well as prion-based disease. The 2017 Gordon Research Conference on "Stress Proteins in Growth, Development and Disease" will highlight the most recent advances in biomedical research of stress biology and stress-related diseases. This conference, the ninth in this series, will be held July 9-14 at the Sunday River Resort in Newry, Maine. The chair is Kevin Morano (UTHealth McGovern Medical School, Houston) and the vice-chair is Elke Deuerling (University of Konstanz, Germany). Special emphasis will be placed on diverse model systems that are being used to investigate stress sensing, signaling and regulation of gene expression, including epigenetic mechanisms. Cutting-edge work on spatial quality control and management of protein misfolding at the ribosome will be highlighted. Connections between compartmental protein folding status and disease will be explored. The conference's collegial and scholarly environment encourages vigorous discussions of exciting developments related to several areas of stress research. To promote the development of junior investigators in the field, a Gordon Research Seminar will be added July 8-9, immediately preceding the GRC. Additionally, we will continue recent meeting innovations of poster teaser talks, career roundtable discussions, programming focused on women investigators in the field. The formal scientific program, limited attendance and organized but informal opportunities for interaction make this meeting a preeminent conference promoting deeper understanding of the versatile roles of stress proteins in human health, aging and disease.

项目摘要一生中，细胞蛋白质组不断暴露于多种蛋白质应激状况。这些包括外部压力，例如温度升高和辐射损伤以及在细胞增殖和分化（例如氧化应激）期间遇到的生理应力，或遗传基因突变引起的蛋白质折叠的挑战。压力细胞的标志和生物是部署蛋白质的全面压力反应稳态包括增加分子伴侣的合成，有助于新生的折叠多肽并防止蛋白质折叠和聚集。蛋白质质量控制和压力保护机械需要严格的信号传导方式和转录程序，其中许多已在疾病状态的数量，包括癌症，心血管疾病，代谢疾病（例如糖尿病）和肝病。压力反应的调节也在寿命调节和衰老中起着至关重要的作用相关疾病，例如阿尔茨海默氏症，帕金森氏症，亨廷顿的疾病以及基于病毒的疾病。 2017年戈登的“生长，发育和疾病压力蛋白”的研究会议将强调了应激生物学和与压力有关的疾病的生物医学研究的最新进展。这会议是本系列的第九个会议，将于7月9日至14日在缅因州纽瑞的Sunday River Resort举行。这主席是凯文·莫拉诺（Kevin Morano）（休斯顿的Uthealth McGovern医学院），副主席是Elke Deuerling （德国康斯坦茨大学）。特别重点将放在正在发生的不同模型系统上用于研究基因表达的压力传感，信号传导和调节，包括表观遗传机制。在空间质量控制和蛋白质错误折叠管理方面的尖端工作核糖体将被突出显示。室蛋白折叠状态和疾病之间的联系将是探索。会议的合作和学术环境鼓励人们对令人兴奋的激烈讨论与压力研究的几个领域有关的发展。促进初级调查人员的发展在该领域，将于7月8日至9日在GRC之前添加戈登研究研讨会。此外，我们将继续遇到海报预告片的创新，职业圆桌讨论，编程的重点是该领域的女性调查员。正式的科学计划，有限的出勤率并有组织但非正式的互动机会使这次会议成为一场杰出的会议，促进对应激蛋白在人类健康，衰老和疾病中的多功能作用更深入地了解。