Research Training in Translational Gastroenterology and Hepatology

转化胃肠病学和肝病学研究培训

• 批准号: 9280922
• 负责人: SAUL J. KARPEN
• 金额: $ 29.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9280922
• 关键词: Gastroenterology; Hepatology; Research Training

 DESCRIPTION (provided by applicant): In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. This is due in part to the application of Big Data including the use of next generation sequencing, proteomics, metabolomics, and systems biology. However major gaps and challenges exist. In order to build on these successes in areas such as inflammatory bowel disease (IBD), nonalcoholic steatohepatitis (NASH), cholestasis and neurogastroenterology, the next generation of researchers must be properly prepared to take advantage of these technologies and translational opportunities. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) will emphasize working at the interface between basic biology and translational medicine to fill important gaps in knowledge and therapeutics. The TP is built upon the strengths of a highly-vetted core of 13 experienced NIH-supported mentors (6 from Pediatrics, 3 from Internal Medicine, and 4 from other Departments), 8 of whom are primarily basic researchers, 3 exclusively clinical researchers, and 2 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are purposefully included. Opportunities to access large multi-center longitudinal studies (NIDDK and non-NIDDK-supported) of children and adults with GI and liver diseases have never been more robust or available, and the leadership for the largest of these in IBD, cholestasis and NASH are TG mentors. This TG application will focus efforts on 2 post-doctoral Trainees (MD or PhD) contemporaneously each year. Trainees will develop expertise as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. The TP incorporates a structured degree program in Masters of Science in Clinical Research for one clinically-oriented MD trainee each year, or a Certificate in Translational Research for basic research MD and PhD trainees, via the Laney Graduate School/Atlanta Clinical and Translational Science Institute (ACTSI). Mentees will benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) is expected to provide a rich and lasting springboard for mentees' careers.

 描述（由应用程序提供）：近年来，胃肠病学和肝病学的患者护理在很大程度上是由采用动物模型和人类受试者的转换为导向的研究的应用所驱动的。越来越多的基础研究方法的交叉授粉正在产生对胃肠道（GI）和肝脏生物学以及疾病发病机理的新见解。这部分是由于大数据的应用，包括使用下一代测序，蛋白质组学，代谢组学和系统生物学。但是，存在主要的差距和挑战。为了在炎症性肠病（IBD），非酒精性脂肪性肝炎（NASH），胆汁淤积和神经胃肠病学等领域取得成功，必须为下一代研究人员做好适当的准备，以利用这些技术和翻译机会。这项培训补助金（TG）的整个目标是为杰出的博士后医学博士，医学博士/博士学位和博士研究人员准备转化胃肠病学和肝病学的成功和有影响力的职业。培训计划（TP）将强调在基本生物学和转化医学之间的界面上工作，以填补知识和治疗的重要空白。 TP建立在13位经验丰富的NIH支持的导师的高度粘性核心的基础上（来自儿科的6名，内科医学中的3个，其他部门的4个），其中8位是主要的基础研究人员，3位独家临床研究人员，其中2名研究组合在基础研究和临床研究之间均匀分配。由于许多成年的胃肠道和肝脏疾病起源于童年，通常会持续生活，因此有目的包括来自成人和小儿专科的导师。获得大型多中心纵向研究（NIDDK和非NIDDK支持的儿童和成年人）患有GI和肝病的机会从未如此强大或可用，并且在IBD，Cholestasis和Nash中，最大的领导者是TG导师。该TG申请每年将重点放在2名博士后学员（MD或PHD）上。在TP执行委员会和导师的监督和指导下，学员将作为消化健康研究人员发展专业知识，并整合内部和外部顾问委员会的意见。 TP每年通过莱尼研究生院/亚特兰大临床和翻译科学研究所（ACTSI），每年为一名面向临床的MD学员的临床研究硕士学位课程或一名基础研究MD和博士学位学员的转化研究证书。受训者将从平衡的奖学金监督委员会中受益，该奖学金委员会具有基本和翻译的专业知识，负责任的研究（RCR）培训课程（RCR）培训和MENEE驱动的个人发展计划（IDP）。预计完成个性化的TP（课程，培训研究经验，环境暴露，建议和专业发展）将为Menees的职业提供丰富而持久的跳板。