Cognitive Control in Children of SUD Parents: A Longitudinal Multimodal MRI Study

SUD 父母子女的认知控制：纵向多模态 MRI 研究

• 批准号: 9114702
• 负责人: Christina W. Hoven
• 金额: $ 15.01万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9114702
• 关键词: 14 year old; Accounting; Address; Adolescence; Adolescent; Age; Alcohol or Other Drugs use; Behavioral; Brain; Child; Cognitive; Conflict (Psychology); Decision Making; Development; Diffusion Magnetic Resonance Imaging; Dimensions; Emotional; Epidemic; Epidemiology; Exposure to; Family; Family history of; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Hyperactive behavior; Image; Individual; Informal Social Control; Intervention; Investigation; Laboratories; Life; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Modality; Multimodal Imaging; National Institute of Drug Abuse; Neurocognitive; Parents; Pattern; Pilot Projects; Play; Prevention strategy; Preventive Intervention; Principal Investigator; Process; Public Health; Recording of previous events; Research; Research Design; Rest; Rewards; Risk; Risk Factors; Risk-Taking; Sample Size; Sampling; Staging; Stimulus; Structure; Substance Use Disorder; Time; Youth; addiction; adolescent substance use; base; cognitive control; cognitive task; conflict resolution; contextual factors; cost effective; critical period; design; discounting; early adolescence; early onset; follow-up; high risk; improved; neural circuit; neurobehavioral; neuroimaging; prospective; trait; treatment strategy

 DESCRIPTION (provided by applicant): Rates of substance use (SU) and substance use disorders (SUD) among adolescents in the US have reached epidemic proportions. An effective early prevention strategy that targets adolescents at high risk for SU/SUD by virtue of family history (FH+) would make a significant and cost-effective contribution. While this relationship is not yet well understood, recent research, including our own NIDA-funded Pilot Study (SUD and Decision-Making: A Pilot Imaging Study of Parents and Children; R21 DA031975; Principal Investigator: C Hoven) has begun to identify deficits in cognitive control, measured both behaviorally and neurobiologically, as key factors involved in adolescent SU/SUD. Our Pilot findings reveal consistently strong hyperactivity and reduced connectivity in the FH+ group in neural circuits thought to play key roles in decision making, reward and addiction. These changes are observed prior to an individuals' exposure to psychoactive substances, thus, reflecting pre- existing vulnerabilities. The findings from our Pilot Study are therefore compellin. The proposed Adolescent Brain Study (ABStudy), using MMRI's (multimodal imaging) at baseline and at 36 months, combined with three formal cognitive tasks, and a developmentally-oriented study design, which includes assessments every three months, has the goal of contributing to the open questions while improving our understanding of FH+ children and their neurobehavioral development. We will combine cutting edge MMRI with the latest neurocognitive laboratory tasks to extend and build upon our Pilot Study, both longitudinally and methodologically, drawing on a non-clinical, epidemiological sample, which has been extensively characterized (5R01DA023733-05 and 5R01DA024029-05; Principal Investigator: C. Hoven). Specifically, we will: 1) Identify the relationship between parental SUD history (FH+/-) and neurobehavioral indicators of cognitive control (behavioral and brain structure/functioning) in their children during early adolescence, 2) Examine the prospective association between FH+/- status and baseline neurobehavioral indicators of cognitive control with subsequent onset and progression of problematic SU trajectories from early adolescence through mid- adolescence, 3) Examine longitudinally associations between FH+/- status, in the development of neurobehavioral indicators of cognitive control, and onset and progression of problematic SU trajectories from early adolescence through mid-adolescence. We will study 150 substance naïve individuals, from early adolescence (ages 12-14), who come equally from FH+/FH- families, and follow them through mid-adolescence (ages 15-17). Importantly, this study will examine the neurobehavioral dimensions while simultaneously, possibly for the first time in an adolescent imaging study, taking into account socio-cultural contextual factors, known to contribute to adolescent SU.

 描述（由适用提供）：美国青少年中的物质使用率（SU）和药物使用障碍（SUD）达到了流行比例。一种有效的早期预防策略，以家族史（FH+）为目标的青少年，将对SU/SUD的高风险产生高风险。 While this relationship is not yet well understood, recent research, including our own NIDA-funded Pilot Study (SUD and Decision-Making: A Pilot Imaging Study of Parents and Children; R21 DA031975; Principal Investigator: C Hoven) has begun to identify deficiencies in cognitive control, measured both behaviorally and neurobiologically, as key factors involved in adolescent SU/SUD.我们的试点调查结果表明，在被认为在决策，奖励和成瘾中起关键作用的神经电路中，FH+组的连通性始终如一。在个人接触精神活性物质之前，可以观察到这些变化，从而反映了预先存在的脆弱性。因此，我们的试点研究的发现是强迫蛋白。拟议的青春期大脑研究（弃权），使用MMRI（在基线）和36个月时使用MMRI（多模式成像），再加上三项正式的认知任务，以及一个面向发达的研究设计设计，包括每三个月的评估，目的是为公开问题做出贡献，同时提高我们对FH+儿童和他们的NeurobeehaveRobeeal and他们的Neurobeeal eyal eyal eyal eyal severy的理解。 We will combine cutting edge MMRI with the latest neurocognitive laboratory tasks to extend and build upon our Pilot Study, both longitudinally and methodologically, drawing on a non-clinical, epidemiological sample, which has been extensively characterized (5R01DA023733-05 and 5R01DA024029-05; Principal Investigator: C. Hoven).具体而言，我们将：1）确定父母SUD病史（FH +/-）与青少年早期的孩子的认知控制（行为和大脑结构/功能）的神经行为指标（行为和大脑结构/功能）之间的关系。中期，3）检查FH +/-状态之间的纵向关联，在开发认知控制的神经行为指标中，以及从青春期早期到中期至未来的有问题的SU轨迹的发作和进展。我们将研究150名来自青少年早期（12-14岁）的受试者，他们同样来自FH+/FH-家族，并在青春期中期（15-17岁）跟随他们。重要的是，这项研究将研究神经行为维度，同时同时考虑到青少年成像研究中的第一次，考虑到社会文化上下文因素，已知会导致青少年SU。