The Compartmental Biology of HIV in the Male Genital Tract

男性生殖道中艾滋病毒的区室生物学

• 批准号: 9339662
• 负责人: MYRON Scott COHEN
• 金额: $ 60.8万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-21 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9339662
• 关键词: AIDS prevention; Anti-Retroviral Agents; Biology; Blood; Cells; Competence; DNA; Detection; Failure; Fumarates; Grant; HIV; HIV-1; Heterosexuals; In Situ; Infection; Interphase Cell; Lead; Liquid substance; Literature; Male Genital Organs; Measures; Mucous Membrane; Nucleosides; Nucleotides; Patients; Pharmaceutical Preparations; Pharmacology; Plasma; Plasma Cells; Prevention; Prevention strategy; Proviruses; RNA; Recovery; Research; Residual state; Reverse Transcriptase Inhibitors; Risk; Seminal; Seminal Plasma; Seminal fluid; Sexual Transmission; Sexually Transmitted Diseases; Source; Tenofovir; Vertebral column; Viral; Virus; Virus Shedding; Woman; Work; design; emtricitabine; genital secretion; men who have sex with men; new technology; pre-exposure prophylaxis; public health relevance; reproductive tract; transmission process

 DESCRIPTION (provided by applicant): HIV is primarily a sexually transmitted disease, resulting from exposure of the mucosa of uninfected people to infected genital secretions. We have studied HIV in semen in order to better understand sexual transmission, and to develop HIV prevention strategies. Work by our group and others has shown that antiretroviral treatment reduces the concentration of HIV in semen, and-accordingly-treated people are less contagious. However, even with treatment HIV RNA can be recovered from seminal plasma and HIV DNA from seminal cells. We would like to understand "residual shedding" of HIV so as to determine ongoing potential for HIV transmission, and to develop strategies to eliminate HIV from the male genital tract. In this Application we propose to better understand the pharmacology of ART in the male genital tract, to study virus shed in spite of treatment, and the conditions (factors) in semen that appear to permit HIV detection. We hope these results will determine the basis for "residual shedding." HIV must be eliminated from the male genital tract to completely abrogate transmission, and to cure the infection.

 描述（由适用提供）：HIV主要是一种性传播疾病，是由于未感染的人的粘膜暴露于感染的生殖器分泌物中。我们已经学习了精液中的艾滋病毒，以便更好地了解性传播并制定艾滋病毒预防策略。我们小组和其他人的工作表明，抗逆转录病毒治疗降低了精液中的艾滋病毒浓度，并且经过治疗的人的感染力较小。但是，即使使用治疗，HIV RNA也可以从第二个血浆和第二个细胞中的HIV DNA中回收。我们想了解HIV的“残留脱落”，以确定持续的HIV传播潜力，并制定从男性生殖道中消除HIV的策略。在此应用中，我们建议更好地了解男性生殖道中艺术的药理学，以研究尽管接受治疗的病毒，以及精液中的疾病（因素）似乎允许HIV检测。我们希望这些结果将确定“剩余脱落”的基础。必须从男性生殖道中消除HIV，以完全消除传播并治愈感染。