Addition of OCD to the Genomic Psychiatry Cohort

将强迫症添加到基因组精神病学队列中

基本信息

批准号：
9228400
负责人：
JAMES A KNOWLES
金额：
$ 74.15万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-03-01 至 2018-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9228400
关键词：
Behavior Biological Bipolar Disorder Brain imaging Clinical Clinical Research Consent Custom DNA Data Deposition Development Disease Distress Electronic Health Record Enrollment Environment European Family history of Family member Follow-Up Studies Funding Genetic Genetic Variation Genetic study Genome Genomics Genotype Goals Health Hereditary Disease Impairment Individual Medical Records Mental disorders Meta-Analysis Molecular Morphologic artifacts Obsession Obsessive-Compulsive Disorder Outcome Study Participant Patients Phenotype Positioning Attribute Prevalence Psychiatry Quality of life Recording of previous events Recruitment Activity Research Research Domain Criteria Research Infrastructure Research Personnel Resources Sample Size Sampling Schizophrenia Statistical Data Interpretation Thinking Time base burden of illness case control cohort compulsion cost effective design exome genetic analysis genetic risk factor genetic variant genome wide association study genome-wide meetings neurocognitive test neuropsychiatry open source population stratification prospective public health relevance sample collection treatment effect whole genome

项目摘要

DESCRIPTION (provided by applicant): This project funds the expansion the Genomic Psychiatry Cohort (GPC) by ascertaining and enrolling 5,000 patients suffering from Obsessive-Compulsive Disorder (OCD) and performing a genome-wide association study (GWAS) on 5,000 OCD patients and 5,000 already ascertained and genotyped OCD-free matched controls. This study is a critical step to achieving the necessary statistical power for discovery. We will more than double the total number of available world-wide participants for GWAS of OCD, and create the only large re-contactable cohort for OCD. The GPC is a large (n=33,000), USC-based, clinical cohort designed to be a major resource for large-scale genomic studies, studies focusing on RDoC and/or other alternate phenotype constructs, nested case- control/clinical studies, long-term disease course studies, and genomic variant-to-phenotype studies (Pato et al, 2013). Additionally, the GPC is "Open Source" in that the cohort can be accessed for additional collaborative studies by approved non-USC based investigators. The GPC is currently composed of patients with schizophrenia (n=10,000), patients with bipolar disorder (n=5,000), family members of these patients (n=3,000) and control participants with no history or family history of OCD, schizophrenia or bipolar disorder (n=15,000). We are able to re-contact more than 88% of the participants. The proposed GPC-OCD cohort and our proven track record of meeting, or exceeding, the sample collection goals for large-scale genetic studies positions us very well to make further progress in understanding the molecular basis of OCD by (i) the discovery of additional genetic risk factors (rare and common); and (ii) identifying a large enough group of specific genetic variations to study how they relate to neuropsychiatric phenotypes at all levels, including, but not limited to, the illnesses themselves.

描述（由申请人提供）：该项目通过确定和注册5,000名患有强迫症的患者（OCD）的患者为基因组精神病学队列（GPC）提供了资金，并对5,000例OCD患者进行了一项全基因组关联研究（GWAS）和5,000名已经确定和基因型OCD型OCD匹配的对照组的患者（GWAS）。这项研究是实现发现必要的统计能力的关键步骤。我们将是OCD GWA的全球参与者总数的两倍以上，并创建OCD唯一大型可连接队列。 GPC是一项大型（N = 33,000），基于USC的临床队列，旨在成为大规模基因组研究的主要资源，重点是RDOC和/或其他替代表型结构，嵌套的病例/临床研究，长期疾病课程研究，以及基因组变体研究以及基因组变体研究（基因组变体研究）（Pato-Pato Et et al，2013）。此外，GPC是“开源”，因为批准的非USC研究人员可以访问该队列以进行其他协作研究。 GPC目前由精神分裂症患者（n = 10,000），躁郁症患者（n = 5,000），这些患者的家庭成员（n = 3,000）和对照参与者组成，没有OCD，精神分裂症或双相情感障碍的病史或家族病史（n = 15,000）。我们能够重新连接超过88％的参与者。拟议的GPC-OCD队列以及我们久经考验的大规模遗传研究的样本收集目标的验证记录，可以很好地确定我们在理解OCD的分子基础上通过（i）发现其他遗传危险因素（罕见和常见）的进一步进步；（ii）鉴定出足够多的特定遗传变异，以研究它们与各级神经精神病学表型的关系，包括但不限于疾病本身。