WG3: HIV, Co-infections and Co-morbidities

WG3：艾滋病毒、合并感染和合并症

• 批准号: 9686011
• 负责人: ASHA R KALLIANPUR
• 金额: $ 0.16万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9686011
• 关键词: AIDS/HIV problem; APOL1 gene; Acquired Immunodeficiency Syndrome; Address; African American; Area; Atherosclerosis; Biological Markers; Biology; Chronic; Clinical; Clinical Research; Collaborations; Comorbidity; Comprehensive Cancer Center; Development; Discipline; Disease; Evaluation; Fertilization; Fostering; Funding; Goals; Grant; HIV; HIV Infections; HIV/TB; Head and Neck Cancer; Heart Diseases; Human; Human Papillomavirus; Immune; Incidence; Inflammation; Institutes; Joints; Journals; Kidney; Laboratories; Link; Malignant Neoplasms; Measurement; Mentors; Microglia; Morbidity - disease rate; Neurocognitive; Neurons; Oncogenic; Pathogenesis; Patients; Peer Review; Prevalence; Process; Public Health; Publications; Publishing; Research; Research Personnel; Research Proposals; Resources; Role; Scientist; Uganda; Viral reservoir; Virus Replication; Vitamin D; Work; antiretroviral therapy; beta-Defensins; cancer education; cancer genetics; cardiogenesis; career; co-infection; design; genetic association; improved; interest; meetings; member; mortality; outcome forecast; pandemic disease; programs; reactivation from latency; risk variant; screening; success; translational scientist; virology; working group

Although antiretroviral therapy (ART) has dramatically altered the prognosis of HIV infection and improved the survival of patients, infected patients continue to suffer significant morbidity and mortality from TB, CVD, malignancies, chronic kidney, and neurocognitive disease. These issues highlight the fact that while ART is very effective at restricting viral replication, there is a pressing need to address the determinants of comorbidities, which are the critical issues in HIV research and the focus of the Working Group 3 agenda. The group has a remit to define scientific priorities in this area for the CFAR and then to facilitate advances in the field by promoting synergistic interactions and collaborative research proposals and advancing the careers of junior investigators. Working Group has 23 members, comprising a critical mass of clinical and translational researchers who have collectively published 423 peer-reviewed publications during the last funding cycle. The primary goal of WG3 is to promote interactions and collaborations between researchers at CWRU and beyond to unravel the biology co-morbid conditions in HIV infections. WG3 promotes this scientific agenda through a variety of activities including (1) facilitating collaborative research by sponsoring seminars, journal clubs, research-in-progress meetings, and targeted meetings to discuss HIV initiatives, (2) forming and participating in national research consortia to promote and disseminate HIV research, and (3) mentoring and promoting the careers of junior investigators. Through these activities, WG3 will promote the following Specific Aims:  To develop new interactions among investigators from various disciplines. Key scientific priorities are:  To stimulate the formation of multi-investigator projects. WG2 success will be defined by the advancement of new collaborative projects, including:  To stimulate cross-fertilization between working groups. In summary, WG3 is focused on promoting key scientific priorities for HIV research in the ART era. This agenda will be supported through targeted activities designed to foster collaborations within the CWRU/UH CFAR, develop supporting resources in the CFAR Cores, especially the Clinical Core D and Uganda Laboratory Core C. The WG3 has placed emphasis on engaging new investigators and has an excellent record of supporting the work of Mentored Scientist Pilot Grant and Catalytic Fund awardees.

尽管抗逆转录病毒疗法（ART）极大地改变了HIV感染的预后和 改善患者的存活率，感染患者继续遭受结核病的显着发病率和死亡率， CVD，恶性肿瘤，慢性肾脏和神经认知疾病。这些问题强调了一个事实，虽然艺术 在限制病毒复制方面非常有效，需要解决合并症的确定剂的迫切需求， 这是艾滋病毒研究中的关键问题，也是工作组3议程的重点。这 小组有一个渠道来定义CFAR的科学优先事项，然后促进进步 通过促进协同互动和协作研究建议，并促进职业生涯 初级调查员。工作组有23名成员，完成了大量的临床和翻译 在上一个融资周期中，共同发表了423个同行评审出版物的研究人员。 WG3的主要目标是促进CWRU及其他地区研究人员之间的互动和合作 为了揭示生物学在HIV感染中的合并状况。 WG3通过各种活动来促进这一科学的Agernda，包括（1）支持协作 赞助的SEMIAR，期刊俱乐部，进行研究的会议以及针对性会议的研究 讨论艾滋病毒倡议，（2）成立和参与国家研究联盟以促进和传播 艾滋病毒研究，以及（3）心理和促进初级研究人员的职业。通过这些活动，WG3 将促进以下特定目标： 发展来自各个学科的研究人员之间的新互动。关键科学 优先事项是： 刺激多入侵器项目的形成。 WG2成功将由 新合作项目的进步，包括： 刺激工作组之间的交叉施肥。 总而言之，WG3专注于在艺术时代促进艾滋病毒研究的关键科学重点。这 议程将通过旨在促进CWRU/UH中的合作的有针对性活动来支持 CFAR，开发CFAR核心的支持资源，尤其是临床核心D和乌干达实验室 核心C. WG3强调吸引新的调查人员，并有很好的支持记录 指导的科学家飞行员赠款和催化基金获奖者的工作。