05 Tissue Biospecimen and Pathology Resource

05 组织生物样本和病理学资源

• 批准号: 9794660
• 负责人: IGNACIO I. WISTUBA
• 金额: $ 94.71万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9794660
• 关键词: Accreditation; Amendment; Animal Model; Animals; Biological; Biological Markers; Blood; Blood Cells; Blood specimen; Cancer Center; Cancer Center Support Grant; Capital; Cataloging; Catalogs; Cell Separation; Cells; Cerebrospinal Fluid; Clinical; Clinical Trials; Collection; Consent; Consultations; Core Facility; Cytology Histology; Ensure; Equipment; Funding; Genomics; Goals; Grant; Guidelines; Head; Health; Histology; Human; Immune; Immunohistochemistry; Immunology procedure; In Situ; In Situ Hybridization; Institution; Institutional Review Boards; International; Journals; Laboratories; Liquid substance; Medicine; Molecular; Paper; Pathologist; Pathology; Patients; Peer Review; Plasma; Procedures; Process; Protocols documentation; Publications; Quality Control; Research; Research Personnel; Resource Sharing; Resources; Secure; Services; Slide; Societies; Specimen; Stains; Standardization; System; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; animal tissue; base; biobank; cell free DNA; data management; digital pathology; exosome; flexibility; human subject; human subject protection; human tissue; immunotherapy clinical trials; improved; innovation; laboratory facility; laser capture microdissection; liquid biopsy; member; molecular pathology; pre-clinical; process optimization; professor; programs; quality assurance; recruit; repository; research study; tissue resource

PROJECT SUMMARY: TISSUE BIOSPECIMEN AND PATHOLOGY RESOURCE (TBPR) The Tissue Biospecimen and Pathology Resource (TBPR) provides a flexible, sophisticated and well-functioning institutional biorepository for human tissue specimens in conjunction with an advanced research histology core facility that supports histopathologic characterization of human and animal tissue specimens. The biorepository Institutional Tissue Bank (ITB) and the Research Histology Facility (RHF) are 2 longstanding, mature, highly functional CCSG-supported shared resources that comprise the TBPR. The ITB is a CLIA-accredited facility that provides center members with access to human tissues, blood, and other fluids obtained from consenting patients under Institutional Review Board-approved protocols. The RHF provides routine and advanced cell- and tissue-based services to investigators. The TBPR supports the entire spectrum of research studies, including biomarker studies in clinical trials as well as basic and pre-clinical animal model research. During the last funding cycle, the ITB recruited board-certified pathologists' assistants to standardize and improve the quality of tissue collection throughout the institution. This effort continues to support new institutional initiatives and strategic alliances on clinical trials for the longitudinal collection of tissue and blood specimens for downstream molecular and immune profiling analyses and the associated implementation of new workflow processes. The TBPR director is Dr. Ignacio Wistuba, chair of Translational Molecular Pathology, and the co-directors are Dr. Stanley Hamilton, head of the Division of Pathology and Laboratory Medicine, and Dr. Dipen Maru, a professor in Translational Molecular Pathology. The TBPR provides key services, including: biospecimen collection, processing, distribution, and quality control; unique, specialized services, such as histochemical stains, immunohistochemistry (IHC), tissue microarray, laser-capture microdissection, in situ hybridization, and digital pathology that utilizes newly acquired, state-of-the-art equipment such as tissue microarrayers, IHC autostainers, and Aperio slide scanners; and new pathology consultation services. Over the last grant cycle, the ITB collected 637,042 specimens, and the RHF performed 1,069,932 procedures. MD Anderson has supported the TBPR with capital equipment funds that total $1,783,014 (ITB $385,387; RHF $1,397,627). Since the previous grant cycle, the ITB and RHL have supported 234 and 499 cancer center members, respectively, and usage was evenly distributed among all 16 CCSG programs. Peer review-funded research accounts for over 80% of total usage, and 32% ($614,243) is requested from the CCSG in grant Yr44. The TBPR facilitated the publication of 481 peer-reviewed papers, including 358 (74%) in journals with IF >5, 159 (33%) in journals with IF >10, and 70 (15%) in journals with IF >20. During the next funding cycle, the TBPR will continue to standardize, streamline, and optimize processes, thereby allowing the facilities to provide high-quality expedited services.

项目摘要：组织生物测量和病理资源（TBPR） 组织生物测量和病理资源（TBPR）提供了灵活，精致且功能良好 人类组织标本的机构生物座与先进的研究组织学核心结合 支持人体和动物组织标本的组织病理学表征的设施。生物座席 机构组织库（ITB）和研究组织学设施（RHF）是2个长期，成熟，高度 构成TBPR的功能CCSG支持的共享资源。 ITB是一个经过CLIA认可的设施 为中心成员提供了通过同意获得的人体组织，血液和其他流体 根据机构审查董事会批准的方案的患者。 RHF提供了常规和高级细胞 - 和 基于组织的服务。 TBPR支持整个研究的范围，包括 临床试验以及基本和临床前动物模型研究中的生物标志物研究。在上次资金中 循环，ITB招募了董事会认证的病理学家的助手，以标准化和提高组织质量 整个机构收集。这项努力继续支持新的机构倡议和战略 在临床试验的联盟中，用于纵向收集组织和血液标本的下游分子 和免疫分析分析以及新工作流程的相关实施。 tbpr 董事是转化分子病理主席Ignacio Wistuba博士，联合主任是Stanley博士 汉密尔顿（Hamilton），病理学和实验室医学司负责 翻译分子病理学。 TBPR提供关键服务，包括：生物循环收集， 处理，分布和质量控制；独特的专业服务，例如组织化学污渍， 免疫组织化学（IHC），组织微阵列，激光捕获显微解剖，原位杂交和数字化 利用新近获得的最先进设备的病理，例如组织微阵列，IHC AutoStainers， 和Aperio幻灯片扫描仪；和新的病理咨询服务。在上一个赠款周期中，ITB收集了 637,042个标本，RHF执行了1,069,932个程序。 MD Anderson支持TBPR 资本设备基金总计1,783,014美元（ITB $ 385,387； RHF $ 1,397,627）。自上一个赠款周期以来 ITB和RHL分别支持234和499个癌症中心成员，使用均匀 分布在所有16个CCSG计划中。同行评估资助的研究占总使用总数的80％以上， 和32％（614,243美元）的CCSG要求在授予YR44中。 TBPR促进了481的出版 经过同行评审的论文，包括358（74％）的期刊，IF> 5，159（33％）在IF> 10和70的期刊中 （15％）在IF> 20的期刊中。在下一个融资周期中，TBPR将继续标准化，简化， 并优化流程，从而允许设施提供高质量的加急服务。