2014 Post-Transcriptional Gene Regulation Gordon Research Conference & Gordon Res

2014年转录后基因调控戈登研究会议

• 批准号: 8785727
• 负责人: Melissa J. Moore
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-16 至 2015-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785727
• 关键词: Academia; Adopted; Animal Model; Area; Bioinformatics; Biopolymers; Cells; Chemicals; Collaborations; Complex; Development; Disease; Evolution; Fostering; Functional RNA; Functional disorder; Gene Expression Regulation; Genetic; Genetic Translation; Genome; Genomics; Goals; Industry; Knowledge; Learning; Life; Mediation; Metabolic; Metabolism; Methodology; Mind; Modification; Neurodegenerative Disorders; Nucleotides; Ointments; Participant; Pharmaceutical Chemistry; Postdoctoral Fellow; Process; RNA; RNA Processing; Regulation; Regulator Genes; Research; Research Personnel; Science; Scientist; Series; Staging; Systems Biology; Therapeutic; Therapeutic Agents; Time; Toxic effect; Translations; Universities; Work; abstracting; base; career; chemical reaction; design; graduate student; high throughput screening; human disease; interest; mRNA Decay; meetings; new therapeutic target; novel therapeutics; peer; planetary Atmosphere; posters; protein complex; protein transport; public health relevance; skills; symposium; therapeutic development; therapeutic target; three dimensional structure

DESCRIPTION (provided by applicant): The 2014 Gordon Research Conference (GRC) on Post-Transcriptional Gene Regulation will be the sixth in a biennial series that began in 2004. This year's meeting will be held July 13-18 at Salve Regina University in Newport, RI, and will be accompanied by a Gordon Research Seminar (GRS) on July 12-13. This GRC and GRS provide outstanding forums to present and discuss new findings about the mediation and regulation of RNA metabolism in normal and diseased states, and how such processes can be targeted and/or harnessed to treat human disease. Elucidating the basic mechanisms of post-transcriptional gene regulation is essential to fully understand the organization, evolution and function of present-day genomes, as well as the involvement of RNA metabolic dysfunction in numerous genetic and acquired disorders. Such fundamental knowledge underpins development of novel therapeutics based on or targeting specific post-transcriptional processes. Areas of emphasis at this year's meeting will include RNA evolution, RNA processing, editing and nucleotide modification, RNA-protein (RNP) complex assembly and dynamics, intra- and extra-cellular RNP transport, mRNA translation and decay, the functions of long and short non-coding RNAs, RNA toxicity, the contributions of abnormal RNA metabolism to congenital and neurodegenerative diseases, and novel therapeutic avenues arising from our ever-increasing understanding of post-transcriptional mechanisms. A key goal of the 2014 meeting is to increase interaction between academic and industrial scientists for their mutual benefit and to facilitate development of novel therapeutics. With this in mind, a significant proportion of this year's speakers come from companies working in this rapidly evolving therapeutic space. The GRC will convene approximately 45 speakers representing key areas of post-transcriptional gene regulation and therapeutic development, with a total of 160-200 participants from both academia and industry. Several short talks will be chosen from abstract submissions. Late afternoon poster sessions will enable all participants to contribute to and learn about the above-mentioned topics. Four top posters will be acknowledged: two graduate students' and two post-docs'. All participants will also interact at meal times and during free early afternoon and late evening periods. While the quality of science will be cutting-edge, the atmosphere is aimed at being relaxed and interactive. For early stage investigators, there will also be a two- day GRS immediately prior to the GRC; the GRS will provide an opportunity for these young scientists to both hone their speaking skills and to become comfortable participating in a high level scientific conference. For graduate students and postdocs interested in pursuing a career in industry, the GRS will include a panel discussion with industry leaders and early stage industry researchers.

描述（由申请人提供）：关于转录后基因调节的2014年戈登研究会议（GRC）将是2004年始于2004年的双年展系列中的第六名。今年的会议将于7月13日至18日在RI的萨尔维·里贾纳大学在RI的Salve Regina University举行，并将在7月12日至13日在Gordon Research Andinar（GRS）陪同。该GRC和GRS提供了出色的论坛，以介绍和讨论有关正常和患病状态中RNA代谢的中介和调节的新发现，以及如何针对和/或利用此类过程来治疗人类疾病。阐明转录后基因调节的基本机制对于充分了解当今基因组的组织，进化和功能以及RNA代谢功能障碍在许多遗传和获得性疾病中的参与至关重要。这种基本知识基于基于或针对特定的转录后过程的新型治疗剂的发展。 Areas of emphasis at this year's meeting will include RNA evolution, RNA processing, editing and nucleotide modification, RNA-protein (RNP) complex assembly and dynamics, intra- and extra-cellular RNP transport, mRNA translation and decay, the functions of long and short non-coding RNAs, RNA toxicity, the contributions of abnormal RNA metabolism to congenital and neurodegenerative我们对转录后机制的理解不断增加的疾病和新颖的治疗途径。 2014年会议的一个关键目标是增加学术和工业科学家之间的互动，以促进他们的相互利益并促进新型治疗学的发展。考虑到这一点，今年的演讲者中有很大一部分来自从事这个快速发展的治疗空间的公司。 GRC将召集大约45位代表转录后基因调节和治疗发展关键领域的演讲者，总共有来自学术界和工业的160-200名参与者。将从抽象提交中选择几个简短的谈判。下午晚些时候，海报会议将使所有参与者能够为上述主题做出贡献和了解。将承认四个顶级海报：两名研究生和两个后介绍者。所有参与者还将在用餐时间和午后和傍晚的免费时间互动。尽管科学的质量将是最先进的，但气氛旨在放松和互动。对于早期的调查人员，在GRC之前还将有两天的GRS。 GRS将为这些年轻科学家提供一个机会，既可以磨练他们的口语技巧，又要参加一场高级科学会议。对于有兴趣从事行业职业的研究生和博士后，GRS将与行业领导者和早期行业研究人员进行小组讨论。