Intravascular Ultrasound Imaging Guidewire with Wireless Readout

具有无线读数功能的血管内超声成像导丝

• 批准号: 8702711
• 负责人: F. Levent Degertekin
• 金额: $ 21.32万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702711
• 关键词: Acoustics; Angiography; Arteries; Back; Balloon Angioplasty; Cardiology; Catheterization; Catheters; Clinical; Complex; Coronary; Data; Development; Devices; Diagnostic; Dimensions; Electronics; Elements; Evaluation; Frequencies; Goals; Heart Diseases; Image; Imagery; Imaging Device; In Situ; In Vitro; Intervention; Lateral; Lead; Lesion; Link; Mechanics; Methods; Miniaturization; Monitor; Myocardial Ischemia; Noise; Outcome; Patients; Performance; Phase; Physiologic pulse; Polychlorinated Biphenyls; Power Sources; Procedures; Process; Radio; Resolution; Risk; Rotation; Safety; Side; Silicon; Stents; Structure; System; Techniques; Technology; Telemetry; Testing; Therapeutic; Time; Ultrasonography; Vascular Diseases; Wireless Technology; base; cold temperature; cost effective; data exchange; design; flexibility; follow-up; imaging modality; implantation; improved; novel; novel diagnostics; novel therapeutics; percutaneous coronary intervention; post intervention; pressure; public health relevance; radiologist; research study; sensor; solid state; tool

DESCRIPTION (provided by applicant): Over a million percutaneous coronary interventions such as balloon angioplasty and stent deployment are performed in the US every year to treat ischemic heart diseases. A thin (0.014") guidewire is used to lead the catheter insertions in nearly all of these procedures. Our aim is to add intravascular ultrasound (IVUS) imaging capability to these guidewires so that cardiologists and interventional radiologists can use this valuable technique as a routine in-situ imaging tool before, during and after interventions without prolonging the procedure time and additional risk to the patient. This flexible IVUS probe will also enable imaging in narrowed and tortuous arteries which cannot be accessed by the existing IVUS probes. The proposed device exploits recent advances in guidewire sensor technology such as pressure (FFR) and flow wires in terms of physical implementation. It uses electrical connections provided on the guidewire for AC power supply for increased safety as well as low phase-noise timebase for wireless/broadband data links. It exploits CMUT-on-CMOS technology to its full extent for electronics integration and in a novel physical arrangement so that 4 separate 1- D phased array IVUS chips provide full cross sectional IVUS images with adequate resolution without any rotation. It integrates broadband (200Mb/s), ultra-compact, short-range, safe and low power (150mW) wireless or over-the-wire data links on the same chip to reduce the cable count down to two, retaining the mechanical performance of the guidewire. Specifically, for initial demonstrations, we plan for 40-45 MHz 1-D CMUT-on- CMOS arrays to match the lateral resolution of commercial 20MHz, 3.5F solid state IVUS arrays. We will investigate a wideband (~200Mb/s) wireless concept based on impulse-radio ultra wideband (IR-UWB) and pulse harmonic modulation (PHM) and two over-the-cable hardwired concepts including RF-back telemetry through power line and fully-differential capacitive readout methods. We will determine the leading candidate from these data link alternatives to implement the IC on a 300umx1000um silicon chip, matching the size of the CMUT IVUS array chips. Finally we will experimentally validate the IVUS on guidewire concept using two-chip (CMUT and Data link) configuration on a PCB through imaging experiments. The proposed project may result in a paradigm shift in interventional cardiology with new diagnostic and therapeutic capabilities for vascular and heart diseases. It will also pave the way for combining FFR and IVUS on a guidewire, essentially implementing 3-in-1 tool, which may improve procedure outcomes in a cost effective manner.

描述（由申请人提供）：每年在美国进行超过一百万个经皮冠状动脉干预，例如气球血管成形术和支架部署，以治疗缺血性心脏病。几乎所有这些过程中的薄（0.014英寸）导线用于引导导管插入。我们的目的是为这些指南添加血管内超声（IVU）成像能力干预之前，期间和之后没有的原位成像工具 延长手术时间和对患者的额外风险。这种灵活的IVUS探针还将在现有的IVUS探针无法访问的狭窄和曲折的动脉中进行成像。所提出的设备利用了指南传感器技术（例如压力（FFR）和流线）的最新进展。它使用指南上提供的电气连接来用于AC电源，以提高安全性以及无线/宽带数据链路的低相位时间库。它将CMUT-on-CMOS技术充分利用电子设备整合和新颖的物理布置，以便4个单独的1- d阶段阵列IVUS芯片提供完整的横截面IVUS IVUS图像，具有足够的分辨率，而无需任何旋转。它集成了宽带（200MB/s），超紧凑，短距离，安全和低功率（150MW）无线或线上的数据链接，以将电缆计数降低到两个，以保持机械性能指南。具体而言，对于初始演示，我们计划40-45 MHz 1-D CMUT-ON-CMOS阵列，以匹配商业20MHz的横向分辨率，3.5F固态IVUS阵列。我们将研究基于Impulse-Radio Ultra宽带（IR-UWB）和Pulse Harmonic调制（PHM）的宽带（〜200MB/S）无线概念，以及两个通过电力线和RF-BACK遥测的台式硬线概念完全差异的电容读数方法。我们将从这些数据链接替代方案中确定领先的候选者，以在300UMX1000UM硅芯片上实现IC，与CMUT IVUS阵列芯片的大小相匹配。最后，我们将通过成像实验在PCB上使用两芯片（CMUT和数据链接）配置在Guidewire概念上实验验证IVU。拟议的项目可能会导致介入心脏病学的范式转移，并具有新的诊断和治疗能力，可用于血管和心脏病。它还将为在指南上组合FFR和IVU的方式铺平道路，从本质上讲，它可以实现3合1工具，这可能会以具有成本效益的方式改善程序结果。