MURINE MODELS CORE

小鼠模型核心

基本信息

批准号：
8375018
负责人：
JEFFREY MINER
金额：
$ 13.47万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8375018
关键词：
Affect Air Air Pressure Alleles Animal Housing Animals Archaea Atomizer Attention Backcrossings Bacteria Bacterial Artificial Chromosomes Bacteroides thetaiotaomicron Bathing Beds Biological Assay Biomedical Research Boston Breeding Budgets Caliber Cancer Center Cells Cesarean section Chromosomes Communities Congenic Strain Core Facility Cryopreservation Custom DNA Data Derivation procedure Devices Diet Dietary Polysaccharide Digestive System Disorders Distal Elbow Embryo Embryo Transfer Engineering Ensure Environment Eubacterium Feces Female Fertilization in Vitro Film Fogs Food Fostering Founder Generation Freezing Future Gastrointestinal tract structure Generations Genes Genetic Genetic Polymorphism Genomics Genotype Germ-Free Glass Gnotobiotic Goals Gossypium Harvest Horns Hour Housing Human Human Resources Ice Immune system Implant Incubated Infection Inflammatory Bowel Diseases Injection of therapeutic agent Intervention Intestines Laboratories Lasers Left Life Liquid substance Maintenance Metabolic Metals Methanobrevibacter Methods Microbe Microsatellite Repeats Modeling Monitor Mothers Mus Mutation Neoprene Nitrogen Nutrient Obesity Oocytes Operative Surgical Procedures Oral cavity Outsourcing Partner in relationship Patient currently pregnant Perivitelline Space Phase Phenotype Physiological Plastics Polymerase Polymorphic Microsatellite Marker Polymorphism Analysis Polyvinyl Chloride Povidone-Iodine Pregnancy Preparation Procedures Process Production Protective Devices Protocols documentation Puncture procedure Quality Control Reaction Research Research Personnel Resources Risk Rodent Running Safety Secure Services Side Single Nucleotide Polymorphism Solutions Speed Staging Stainless Steel Stem cells Sterility Sterilization Superovulation Surface Swab System Techniques Technology Temperature Testing The Jackson Laboratory Thick Time Transfection Transgenes Transgenic Organisms Transplantation Triad Acrylic Resin Universities Uterus Vitamin K Washington Water Work X Chromosome Y Chromosome Zona Pellucida animal colony assisted reproduction base blastocyst chlorine dioxide congenic density design embryo cell embryo stage 2 embryo/fetus embryonic stem cell fiberglass flexibility fungus gastrointestinal system genetic pedigree gut microbiota homologous recombination interest male medical schools microbial microbial community mouse genome mutant mylar offspring ovary transplantation pathogen pathogenic bacteria pregnant prevent processing speed pup quality assurance research study seal vector web site

项目摘要

Murine models have been extensively utilized by Washington University Digestive Diseases Research Core Center investigators and are central to DDRCC biomedical research into inflammatory bowel disease and other aspects of the digestive system. The Murine Models Core has been and will continue to be dedicated to producing genetically altered animals and to providing gnotobiotic mice for DDRCC investigators in a timely and reliable manner. In addition, the Core provides ancillary sen/ices for maintaining mouse pedigrees, such as assisted reproduction and cryopreservation of embryos, as well as rapid transfer of mutations or transgenes from one genetic background to another using "speed congenics". We will continue to offer these services in the next project period.

小鼠模型已被华盛顿大学消化疾病研究广泛使用核心中心研究人员，是 DDRCC 炎症性肠病和生物医学研究的核心消化系统的其他方面。小鼠模型核心已经并将继续致力于生产转基因动物并及时为 DDRCC 研究人员提供无菌小鼠和可靠的方式。此外，核心还提供用于维持小鼠谱系的辅助服务，例如如胚胎的辅助生殖和冷冻保存，以及突变或转基因的快速转移使用“速度遗传”从一种遗传背景转移到另一种遗传背景。我们将继续在以下地区提供这些服务下一个项目期。