Clinical Bone Mechanics Using HR-pQCT and ??MRI

使用 HR-pQCT 和 MRI 进行临床骨力学

• 批准号: 8260471
• 负责人: X. Edward GUO
• 金额: $ 64.94万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8260471
• 关键词: 3-Dimensional; Address; Age; Biomechanics; Bone Density; Bone Tissue; Clinical; Competence; Data; Development; Distal; Effectiveness; Elements; Failure; Fracture; Gold; Image; Individual; Ionizing radiation; Laboratories; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Metabolic Bone Diseases; Methods; Modality; Modeling; Noise; Osteoporosis; Patients; Peripheral; Property; Radial; Recording of previous events; Research; Research Personnel; Resolution; Risk; Risk Factors; Scanning; Signal Transduction; Site; Skeleton; Spinal Fractures; Techniques; Technology; Testing; Thick; Time; Woman; X-Ray Computed Tomography; base; bone; bone geometry; bone health; bone imaging; bone strength; clinically relevant; dual diagnosis; high standard; imaging modality; in vivo; lumbar vertebra bone structure; mineralization; novel; osteoporosis with pathological fracture; peer; public health relevance; skeletal; spine bone structure; substantia spongiosa; tibia; tool; vertebra body

DESCRIPTION (provided by applicant): Recent advances in high-resolution imaging have permitted the development of new tools, notably micro- magnetic resonance (5MR) imaging and high-resolution peripheral quantitative computed tomography (HR- pQCT), that promise to provide a better profile of overall bone strength beyond areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA). In this application, we seek to determine whether image- based microstructural and 5FE analyses can distinguish between individuals who have vertebral fractures from their counterparts without vertebral fractures. In the proposed project we advance the following hypotheses: 1. Morphological measurements and 5FE predictions of stiffness and failure load of the distal tibia and radius from ex vivo 5MRI and HR-pQCT correlate highly with those from 5CT and direct mechanical testing, and, furthermore, that parameters from the two peripheral sites parallel those in the vertebrae. 2. 5FE-derived estimates of elastic stiffness and failure load from in vivo 5MR and HR-pQCT images can differentiate between individuals with vertebral fractures from those without vertebral fractures better than microstructural measures derived by the two imaging modalities alone or aBMD by DXA. We plan to address the above hypotheses with the following specific aims: Specific Aim 1a: Perform 5MRI and HR-pQCT scans of the distal tibia and radius ex vivo under signal-to-noise and resolution conditions achievable in vivo, and compare trabecular and cortical bone microstructural measurements obtained in this manner with those from high-resolution 5CT. Specific Aim 1b: Compare the stiffness and failure load of whole bone segments of the distal tibia and radius as predicted by HR-pQCT and 5MR image-based nonlinear 5FE analyses to those predicted by 5CT image- based 5FE analysis and direct mechanical testing. Specific Aim 2a: Perform 5CT scans of lumbar vertebrae from the same subjects as the distal tibia and radius used in Aims 1a and 1b Specific Aim 2b: Compare trabecular and cortical bone microstructural measurements and 5FE predictions based on the imaging data obtained by HR-pQCT and 5MRI in Aims 1a and 1b with the 5CT measurements and direct mechanical testing of the corresponding vertebrae in Aim 2a. Specific Aim 3a: Apply the microstructural and 5FE techniques validated in Aims 1 and 2 to in vivo 5MRI and HR-pQCT scans from healthy women and compare these measurements between the two imaging modalities. Specific Aim 3b: Apply the microstructural and 5FE techniques validated in Aims 1 and 2 to the two peripheral imaging modalities and determine the effectiveness of methods in distinguishing between vertebral fracture subjects and their non-fractured peers using data from two imaging studies previously performed or currently in progress in the investigators' laboratories. PUBLIC HEALTH RELEVANCE: High-resolution peripheral quantitative computed tomography (HR-pQCT) and micro magnetic resonance imaging (5MRI), which are state-of-the-art clinical high-resolution imaging modalities for the skeleton, will be validated for the determination of mechanical competence and prediction of vertebral fractures. This research will test the feasibility and establish the standard of high-resolution skeletal imaging in assessing bone health beyond the areal bone mineral density measurements obtained by dual-energy x-ray absorptiometry (DXA).

描述（由申请人提供）：高分辨率成像的最新进展允许开发新工具，特别是微电磁共振（5MR）成像和高分辨率外周三位数计算机断层扫描（HR-PQCT），它有望通过dual-eNergy（abmd）的整体骨骼强度（ABMD）的整体骨强度更好地提供整体骨强度的概况（abmd）。在此应用程序中，我们试图确定基于图像的微结构和5FE分析是否可以区分椎骨骨折的个体，而没有椎骨骨折。在拟议的项目中，我们提出了以下假设：1。对胫骨远端和半径的形态测量和5FE预测，来自ex Vivo 5MRI和HR-PQCT的刚性和失败负载与5CT和直接机械测试的刚性和HR-PQCT高度相关，并且此参数来自两个围绕位点的参数。 2。5FE衍生的估计值对体内5MR和HR-PQCT图像的弹性刚度和故障负荷可以区分椎骨骨折的个体与没有椎骨骨折的人比单独的两种成像方式或DXA ABMD的微观结构措施更好地分化了没有椎骨骨折的人。我们计划以以下特定目的解决上述假设：具体目标1A：在信噪比和分辨率条件下进行5MRI和HR-PQCT扫描，在体内可实现的信噪比和分辨率条件下，并比较小径和皮质骨微结构测量，并以这种高度分别从高分位5ct中获得。特定目标1B：将HR-PQCT和基于5MR图像的非线性5FE分析与5CT图像基于5CT图像的5FE分析和直接机械测试所预测的人所预测的那样，将胫骨远端和半径的整个骨骼段的刚度和失效负荷进行比较。具体目的2a：进行5CT扫描与目标1A和1B特定目标中使用的远端胫骨和半径相同的受试者进行5CT扫描：比较小梁和皮质骨微结构测量和5FE预测基于HR-PQCT和5MRE在1A和5CT的成像中获得的成像数据的预测，并比较1A和5CT的成像。在AIM 2A中。特定目标3a：应用AIM 1和2中验证的微观结构和5FE技术中的体内5MRI和HR-PQCT扫描，并从健康女性中进行扫描，并比较两种成像方式之间的这些测量。特定目标3B：将AIM 1和2中验证的微观结构和5FE技术应用于两个外围成像模式，并确定方法在研究研究员实验室中先前进行或目前在研究人员实验室中进行的两个成像研究或目前正在进行的成像研究中的数据来区分椎骨骨折受试者及其非裂缝对等方面的有效性。 公共卫生相关性：高分辨率外围定量计算机断层扫描（HR-PQCT）和微磁共振成像（5MRI），它们是骨架的最先进的临床高分辨率高分辨率示范性的，用于确定椎骨菌株的机械能力和预测。这项研究将测试可行性，并建立高分辨率骨骼成像的标准，以评估通过双能X射线吸收测定法获得的面积骨矿物质密度测量值（DXA）获得的骨骼健康。