Device to mechanically interrogate tissue and skin across research environments

在研究环境中机械询问组织和皮肤的设备

• 批准号: 8681920
• 负责人: Qi Wang
• 金额: $ 14.84万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8681920
• 关键词: Device; mechanically; interrogate; tissue; skin

Device to mechanically interrogate tissue and skin across research environments Relative changes in the tissue's response to mechanical deformation have been used for centuries to diagnose and classify diseases and often serve as surrogates for assessment of disease stage or progression. Pathological conditions such as arterial, venous, diabetic, lymphatic and collagen vascular disease are manifested in macroscopic and microscopic structural changes in the skin and soft tissues. Many devices have been designed to measure and describe the mechanical properties of skin in vivo and some devices have attained success in certain research environments. However, a remaining need exists for a device that is compatible with both lab-based and clinically-based research. Current device have not been proven useful for both types of research environments. In this project, we will develop a low-cost, portable technology, the mechanical interrogation of tissue and skin device (MITS), to quickly and accurately quantify the mechanical properties of the tissue and skin within a variety of healthcare research settings. Because skin and tissue research spans a wide range of clinical conditions, in this project we must focus on a few examples in order to develop MITS for versatile and wide ranging applications. Specifically, we will 1) Engineer the MITS hardware and software for multiple research applications and environments, 2) Model and optimize MITS performance using tissue phantoms, 3) Optimize MITS for use in animal (wound) and human (pressure ulcer and edematous limb) research utilizing an iterative design approach. The novelty of the MITS device is its small form factor, small area of interrogation, high bandwidth, and its readiness to utilize variable excitation patterns. While this project is focused on developing a versatile research instrument, the simplicity and small form factor of the MITS can form the basis for the development of a clinical diagnostic device. Since a design objective includes utility in a variety of clinical research environments, one can envision later development work to focus on clinical applications. The potential of having a clinical tool based upon the same technical principles of a research instrument would streamline the translation of research findings into clinical applications.

在研究环境中机械询问组织和皮肤的设备 几个世纪以来，已经使用了组织对机械变形的反应的相对变化来诊断 并分类疾病，并经常用作评估疾病阶段或进展的替代物。 病理状况，例如动脉，静脉，糖尿病，淋巴和胶原蛋白血管疾病 体现在皮肤和软组织中的宏观和显微镜结构变化中。许多设备都有 被设计用于测量和描述体内皮肤的机械性能，某些设备具有 在某些研究环境中取得了成功。但是，剩余的需求对设备的需求 与基于实验室和基于临床的研究兼容。当前的设备尚未证明对 两种研究环境。 在这个项目中，我们将开发一种低成本的便携式技术，组织的机械询问和 皮肤装置（MIT），以快速准确地量化组织和皮肤的机械性能 各种医疗研究环境。因为皮肤和组织研究跨越了广泛的临床 条件，在这个项目中，我们必须专注于一些示例，以开发多功能和广泛的MIT 范围应用程序。具体来说，我们将1）设计MITS硬件和软件进行多项研究 应用和环境，2）使用组织幻像建模并优化MITS性能，3）优化 用于动物（伤口）和人（压力溃疡和水肿的肢体）的MIT，利用迭代 设计方法。 MITS设备的新颖性是其较小的外形，审讯的小面积，高 带宽及其准备使用可变激发模式的准备。该项目专注于开发 一种多功能的研究工具，简单性和小核心的尺寸很小，可以构成 开发临床诊断装置。由于设计目标包括各种临床的实用程序 研究环境，人们可以设想以后的开发工作，以关注临床应用。这 基于研究工具的相同技术原理的临床工具的潜力将 简化研究结果转化为临床应用。