A handheld scanner for clinical oximetry

用于临床血氧测定的手持式扫描仪

• 批准号: 8353211
• 负责人: PERIANNAN KUPPUSAMY
• 金额: $ 18.33万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8353211
• 关键词: Americas; Amputation; Biological; Biopolymers; Blood flow; Body Regions; Calibration; Chronic; Clinical; Computer Simulation; Computer software; Custom; Development; Devices; Diagnostic; Diffusion; Dimensions; Disease; Electrodes; Electron Spin Resonance Spectroscopy; Elements; Encapsulated; Heating; Human Volunteers; Hyperbaric Therapy; Implant; Magnetism; Measurement; Measures; Methods; Modeling; Monitor; Neonatal Intensive Care; Operative Surgical Procedures; Oxygen; Oxygen saturation measurement; Penetration; Perfusion; Peripheral Vascular Diseases; Physiologic pulse; Polymers; Rattus; Reading; Reconstructive Surgical Procedures; Research Proposals; Sampling; Skin; Subcutaneous Tissue; Surface; Surgical Flaps; System; Techniques; Temperature; Testing; Time; Tissue Grafts; Tissues; Topical application; Transplantation; Ultrasonography; Validation; Weight; Work; Wound Healing; base; clinical application; clinically significant; design; design and construction; implantation; in vivo; instrument; instrumentation; interest; magnetic field; microwave electromagnetic radiation; minimally invasive; new technology; prototype; sensor; subcutaneous; success; tissue oxygenation; tool; wound

DESCRIPTION (provided by applicant): Measurement of transcutaneous oxygen perfusion through the skin is used clinically as a measure of blood flow to a region of the body, and serves as an indicative measure of wound healing potential. Topical oximetry may also be useful for tracking peripheral vascular disease (PVD). Currently, the only clinically-applied technique used for this purpose is transcutaneous oxygen monitoring (TCOM) using electrode based sensors, which require an active heating element to encourage diffusion of oxygen through the skin. Subcutaneous (2 - 3 mm below the skin surface) tissue oxygen measurements would be useful in determining blood flow in vascularized free tissue flaps used for reconstructive surgery or in tissues surrounding chronic wounds. Our group has demonstrated that biopolymer-encapsulated probes used in electron paramagnetic resonance (EPR) oximetry can be used for such applications when applied topically to the region of interest, or implanted below the skin. The use of EPR for such measurements is currently not feasible in a clinical setting due to the size, weight, and space restrictions presented by existing instrumentation. We therefore propose to design, build, and test a new, portable EPR system for clinical oximetry applications. The envisioned device will be similar to a clinical ultrasound unit, with a "wand" assembly that will be placed in contact with the skin to obtain oximetry measurements from the probe sensors placed on the body, or implanted just below the surface. We will use computer modeling to determine the optimum arrangement of magnets and resonator prior to construction of a working prototype device. We will then test and characterize the oxygen-sensitive probes to be used. We will then use the prototype device to quantify tissue oxygenation in a rat chronic wound model, and continue with validation measurements using the portable EPR unit on human volunteers to compare this new technology with the existing electrode-based TCOM. PUBLIC HEALTH RELEVANCE (provided by applicant): Diffusion of oxygen through the surface of the skin (transcutaneous oxygen diffusion) can be used as a diagnostic tool for a number of different diseases and conditions, including peripheral vascular disease (PVD). Subcutaneous tissue oxygen levels can be used as an indicator of wound healing potential or tissue graft transplant success. The objective of this proposal is to design and construct a new device which will permit accurate and rapid quantification of transcutaneous oxygen perfusion and subcutaneous (2 - 3 mm below the skin) oxygen levels in clinical settings.

描述（由申请人提供）：在临床上测量通过皮肤的经皮氧灌注的测量作为量度的量度，以衡量流向人体区域的血液流动，并用作伤口愈合潜力的指示度量。局部血氧饱和度可能也可用于跟踪周围血管疾病（PVD）。当前，用于此目的的唯一临床应用技术是使用基于电极的传感器的经氧监测（TCOM），该传感器需要一个主动的加热元件来鼓励氧气通过皮肤扩散。皮下（皮肤表面以下2-3毫米）组织氧测量将有助于确定用于重建手术的血管化自由组织皮瓣或周围慢性伤口周围组织中的血液流动。 我们的小组已经证明，当局部应用于感兴趣的区域或在皮肤下方植入时，可用于电子顺磁共振（EPR）的生物聚合物封装的探针可用于此类应用。由于现有仪器提出的尺寸，重量和空间限制，目前在临床环境中使用EPR进行此类测量是不可行的。因此，我们建议设计，构建和测试用于临床血氧仪应用的新的便携式EPR系统。 设想的设备将类似于临床超声单元，其“魔杖”组件将与皮肤接触，以从放置在体内的探针传感器或在表面下方植入的探针传感器获得血氧仪测量。我们将使用计算机建模来确定在构建工作原型设备之前的磁铁和谐振器的最佳布置。然后，我们将测试并表征要使用的氧敏感探针。然后，我们将使用原型设备来量化大鼠慢性伤口模型中的组织氧合，并使用人类志愿者的便携式EPR单元继续进行验证测量，以将该新技术与现有的基于电极的TCOM进行比较。 公共卫生相关性（由申请人提供）：氧通过皮肤表面的扩散（经皮氧扩散）可用作多种不同疾病和病情的诊断工具，包括外周血管疾病（PVD）。皮下组织氧水平可以用作伤口愈合潜力或组织移植移植成功的指标。该提案的目的是设计和构建一种新设备，该设备将允许在临床环境中准确，快速定量皮肤氧灌注和皮下（皮肤低于皮肤以下2-3 mm）的氧气。