Mentoring Research Excellence in Aging and Regenerative Medicine

指导衰老和再生医学领域的卓越研究

• 批准号: 10851107
• 负责人: S MICHAL JAZWINSKI
• 金额: $ 105.48万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10851107
• 关键词: Address; Administrative Supplement; Affect; Aging; Amputation; Anti-Inflammatory Agents; Apoptosis; Apoptotic; Applications Grants; Architecture; Area; Bioinformatics; Biological Aging; Cell Communication; Cell physiology; Cells; Cementation; Centers of Research Excellence; Cessation of life; Chronic; Chronic Disease; Cicatrix; Coculture Techniques; Collaborations; Collagen; Communities; Data; Data Set; Degenerative Disorder; Deposition; Digit structure; Disease; Distal; Elements; Environment; Extracellular Matrix; Extramural Activities; Faculty; Feedback; Fibroblasts; Fibrosis; Funding; Genomics; Goals; Growth; Homeostasis; Impairment; Inflammation; Inflammatory; Infrastructure; Injury; Interdisciplinary Study; Intervention; Kidney; Knowledge; Liver; Lung; Macrophage; Measures; Mentors; Molecular; Morbidity - disease rate; Morphology; Mus; Musculoskeletal; Myofibroblast; NADPH Oxidase; Natural regeneration; Organ; Pathologic; Pathology; Pathway interactions; Pharmaceutical Preparations; Phenotype; Pilot Projects; Play; Positioning Attribute; Process; Production; Public Health; Publishing; Pulmonary Fibrosis; Reactive Oxygen Species; Regenerative Medicine; Regenerative research; Research; Research Personnel; Resistance; Risk Factors; Role; Services; Signal Transduction; Source; Specimen; Talents; Testing; Therapeutic Intervention; Time; Tissues; Transforming Growth Factor beta; United States; Update; body system; callous unemotional trait; career development; cell type; comparative; comparison control; digit regeneration; effective therapy; genotoxicity; healing; in vivo; inhibitor; lung injury; lung repair; mortality; multiple omics; paracrine; profibrotic cytokine; programs; repaired; senescence; soft tissue; success; sustainable resource; therapeutic development; tissue culture; tissue regeneration; tissue repair; transcriptomics; virtual; wound healing

Aging is a process that is the major risk factor for chronic disease and degeneration. However, it is beginning to be appreciated that disease and degeneration impinge on biological aging, in something akin to a feedback loop, suggesting that a better knowledge of one contributes to an understanding of the other. This necessitates that development of therapeutic interventions must address the degenerative disorders of aging, while the search for broad interventions that target the biological aging process itself continues. This agenda calls for the creation and nurturing of an environment in which multidisciplinary research of sufficient breadth is focused on key elements of aging and regeneration. At the same time, it is necessary to populate this translational space with talented and successful investigators. The project goals are to: (1) Continue to expand the number of aging and regeneration research-oriented, funded investigators within the scientific community at Tulane through pilot projects, with emphasis on collaborative research, and to provide a mentoring program for these researchers and others that supports successful career development. (2) Maintain the state-of-the-art infrastructure to provide sustainable resources that continuously enhance the competitiveness of center faculty for national funding, by expanding and updating the services performed by our Genomics, Bioinformatics, and Spatial Multiomics Core. (3) Cement the position of the Tulane Center for Aging at the forefront of aging and regenerative medicine by growth of its thematic, multidisciplinary research foci to facilitate successful extramurally funded collaborations that will support and sustain the center. The COBRE project leaders have coalesced into four research foci, one of which is Musculoskeletal and Soft Tissue Adaptation and Homeostasis. It is this area that is targeted for this administrative supplement. Extrinsic and intrinsic damage to body organs is constantly a threat to homeostasis during aging. Bodies can repair such damage rather well if it is not too severe. In fact, there are a few examples of near perfect repair that we can call regeneration, such as the regeneration of the digit tip. However, if the damage is extensive or chronic, the result is pathological healing that leaves behind a fibrotic scar compromising organ function. Virtually all organs are capable of repair and renewal and are prone to this pathology to a lesser or greater extent. The premise is that there are similarities, at the molecular and cellular levels, in fibrosis in these various organ systems, in addition to the differences, that can illuminate the factors that contribute to regeneration rather than fibrosis. These factors may best be uncovered using a comparative approach in several organ systems. To best leverage this approach, a team of experts in repair, regeneration, and fibrosis, in several different organs will be assembled, starting with the amputated digit tip and the damaged lung, along with experts in bioinformatics to facilitate unraveling its complexity in these organ systems. Their singular goal is to elucidate fibrosis – repair gone wrong. Fibroproliferative disorders account for 45% of the deaths in the United States, thus this research has significant public health impact.

衰老是慢性疾病和退化的主要危险因素，但这一过程已经开始发生。 应该认识到，疾病和退化会影响生物衰老，类似于反馈循环， 表明对一个事物的更好了解有助于对另一个事物的理解。 治疗干预措施的发展必须解决衰老的退行性疾病，同时寻找 针对生物衰老过程本身的广泛干预措施仍在继续。 培育一个环境，使足够广度的多学科研究集中在关键问题上 同时，有必要在这个转化空间中填充老化和再生的元素。 该项目的目标是：（1）继续扩大老龄化和成功的研究人员数量。 以再生研究为导向，通过试点资助杜兰大学科学界的研究人员 项目，重点是合作研究，并为这些研究人员提供指导计划 以及其他支持成功职业发展的因素 (2) 维护最先进的基础设施以提供服务。 可持续的资源，不断增强中心教师争取国家资助的竞争力， 扩展和更新我们的基因组学、生物信息学和空间多组学核心提供的服务。 (3) 巩固杜兰大学老龄化中心在老龄化和再生医学领域的前沿地位 扩大其专题、多学科研究重点，以促进成功的校外资助合作 COBRE 项目领导者已合并为四个研究重点，其中之一是支持和维持该中心。 其中肌肉骨骼和软组织适应和稳态正是这个领域的目标。 对身体器官的外在和内在损害始终对体内平衡构成威胁。 在衰老过程中，如果损伤不太严重，身体可以很好地修复。事实上，有几个例子。 近乎完美的修复，我们可以称之为再生，例如指尖的再生。 损伤是广泛或慢性的，结果是病理性愈合，留下纤维化疤痕 几乎所有器官都能够修复和更新，并且较容易发生这种病理变化。 或更广泛的前提是，在分子和细胞水平上，纤维化存在相似之处。 这些不同的器官系统，除了差异之外，还可以阐明导致 这些因素最好通过几个方面的比较方法来揭示。 为了最好地利用这种方法，修复、再生和纤维化方面的专家团队在多个领域进行了研究。 不同的器官将与专家一起组装，从截肢的指尖和受损的肺部开始 他们的唯一目标是阐明这些器官系统的复杂性。 纤维化——修复错误导致美国 45% 的死亡。 这项研究具有重大的公共卫生影响。