A Gesture-Powered Software Platform of Neurologic Music Therapy Games and Puzzles: To Stimulate Neuroplasticity and Prolong Functional Independence in Individuals Diagnosed with Alzheimer's Disease

神经音乐治疗游戏和谜题的手势驱动软件平台：刺激阿尔茨海默病患者的神经可塑性并延长功能独立性

• 批准号: 10852784
• 负责人: Peter Gray
• 金额: $ 25万
• 依托单位: OUTLIER TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10852784
• 关键词: Address; Aging; Algorithms; Alzheimer' s Disease; Board Certification; Brain; Characteristics; Cognitive; Collaborations; Communities; Computer Vision Systems; Computer software; Data; Data Analytics; Data Display; Development; Diagnosis; Disease; Educational Curriculum; Emotional; Esthetics; Event; Evidence based intervention; Gestures; Habilitation; Health; Impaired cognition; Impairment; Individual; Intervention; Intuition; Learning; Maps; Medical; Modality; Modernization; Motion; Movement; Music; Music Therapy; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Outcome; Pathogenesis; Patient-Focused Outcomes; Patients; Personal Satisfaction; Persons; Play; Process; Rehabilitation therapy; Resources; Sampling; Social outcome; Taste Perception; Technology; Therapeutic; Time; Translating; Treatment Protocols; Well in self; data portal; design; experience; functional independence; haptic feedback; healing; improved; innovation; insight; instrument; musician; neural; neural circuit; neuropathology; next generation; novel; novel strategies; pain reduction; prototype; repaired; structured data; targeted treatment; therapeutic candidate

Abstract The inclusion of music therapy into a total treatment modality can be used to improve the cognitive, physical, emotional, and social outcomes of patients diagnosed with neurological aging disorders, such as Alzheimer’s Disease (AD). Moreover, the healing benefits of music therapy and music-based interventions may be optimized when the patient is actively engaged in the process of creating music (composing, singing, moving), as opposed to sole reliance on receptive or passive music listening. The process of creating music has been shown to enhance neuroplasticity, reduce pain, and promote mental wellness. AD, in particular, as a neurodegenerative disease characterized by adverse neuropathological changes that impair neural connectivity and the brain’s natural ability to repair itself, is a prime candidate for the therapeutic neurological benefits that arise from creating music. Unfortunately, however, those who stand to gain the most from creating music often find the challenging process of relearning, learning, and/or manipulating a musical instrument to be impractical. Outlier Technology (Outlier) seeks to address this issue by developing a novel, Neurologic Music Therapy (NMT)-based software platform to help modernize the rehabilitation and habilitation of function & well-being among people suffering from AD. This next-generation approach to NMT will offer the medical community an innovative new way to enhance neuroplasticity and mitigate cognitive decline. The hallmark of this platform is a proprietary algorithm which utilizes computer vision as an input modality to translate body movements into an interactive, aesthetically pleasing musical experience integrated with a data-driven curriculum of NMT-based puzzles and games designed in collaboration with Board-Certified Music Therapists (MT-BCs) to target therapeutic objectives. This platform can be utilized by therapists to augment their traditional treatment regimens or by patients who do not have regular access to therapy resources but seek the potential benefits of such use. This proposal describes the development of a gesture-powered “smart instrument” that combines an interactive, adaptive, and therapeutic music creation experience with structured data analytics. Musical data from studio musicians will be sampled, analyzed, and mapped onto an aesthetically refined decision matrix that produces pleasing, software-generated music that may be customized to the user’s personal tastes. Computer vision will be used to map physical movements onto sensible musical outcomes to develop a “smart instrument” with intuitive, motion-powered haptic feedback. A curriculum of NMT-based games and puzzles that utilize this instrument will be developed with neuroscientists and MT-BCs to stimulate neuroplasticity and prolong functional independence. We will also integrate a data portal which allows the practitioner to record real-time patient events and notes about session progress, and access organized displays of data from each session which identify musical characteristics with strong associations to positive patient outcomes. The proposed development will yield a prototype demonstrating proof-of-concept for a groundbreaking new approach to AD rehabilitation.

抽象的 将音乐疗法纳入整体治疗方式可用于改善认知、身体、 被诊断患有神经性衰老疾病（例如阿尔茨海默病）的患者的情绪和社会结果 此外，音乐疗法和基于音乐的干预措施的治疗效果可能会得到优化。 当患者积极参与创作音乐的过程（作曲、唱歌、移动）时，而不是 音乐创作的过程已被证明可以完全依赖于接受性或被动性的聆听。 增强神经可塑性，减轻疼痛，促进精神健康，特别是作为一种神经退行性疾病。 以损害神经连接和大脑功能的不良神经病理变化为特征的疾病 自然的自我修复能力是神经系统治疗益处的主要候选者，这种益处是通过创造 然而不幸的是，那些从创作音乐中获益最多的人往往会发现充满挑战。 重新学习、学习和/或操作乐器的过程是不切实际的。 离群技术（Outlier）试图通过开发一种新颖的神经音乐疗法来解决这个问题 基于神经机器翻译 (NMT) 的软件平台，帮助实现功能和福祉的康复和康复现代化 这种下一代 NMT 方法将为医学界提供一种治疗方法。 该平台的特点是增强神经可塑性和减轻认知能力下降的创新方法。 该算法利用计算机视觉作为输入方式，将身体动作转化为 互动、美观的音乐体验与基于 NMT 的数据驱动课程相结合 与委员会认证的音乐治疗师 (MT-BC) 合作设计的谜题和游戏，以瞄准 治疗师可以利用该平台来增强他们的传统治疗方案。 或无法定期获得治疗资源但寻求此类使用的潜在益处的患者。 该提案描述了一种手势驱动的“智能仪器”的开发，该仪器结合了 通过结构化数据分析获得交互式、自适应和治疗性音乐创作体验。 工作室音乐家将被采样、分析并映射到一个美观精致的决策矩阵上 产生令人愉悦的软件生成的音乐，可以根据用户的个人品味进行定制。 视觉将用于将身体运动映射到可感知的音乐结果上，以开发“智能乐器” 具有直观的、由动作驱动的触觉反馈，基于 NMT 的游戏和谜题课程。 仪器将与神经科学家和 MT-BC 一起开发，以刺激神经可塑性并延长功能 我们还将集成一个数据门户，使医生能够记录实时患者事件。 并记录会话进度，并访问每个会话的数据的组织显示，这些数据确定 所提议的开发将与积极的患者结果密切相关的音乐特征。 产生一个原型，展示 AD 康复的突破性新方法的概念验证。