Determinants and Consequences of Low Vitamin D in Populations of African Descent

非洲人后裔人群维生素 D 水平低下的决定因素和后果

• 批准号: 8689246
• 负责人: Ramon Angel Durazo-Arvizu
• 金额: $ 8.86万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8689246
• 关键词: Address; Adult; African; African American; Age; Biochemical; Biogenesis; Biology; Blood Pressure; Body Composition; Body Weight Changes; Bone Density; Calcium; Cholesterol; Chronic Disease; Clinical; Clinical Research; Communities; Country; Data; Diet; Dietary intake; Disease; Dual-Energy X-Ray Absorptiometry; Energy Metabolism; Environment; Epidemiology; Fasting; Fracture; Funding; Genes; Ghana; Glucose; Health; Hormones; Hypertension; Insulin; Intake; International; Jamaica; Label; Leptin; Life Style; Light; Link; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolic Marker; Metabolism; Mexican Americans; Minerals; Modeling; Monitor; National Health and Nutrition Examination Survey; Normal Range; Nutritional; Obesity; Parathyroid gland; Pattern; Persons; Physical activity; Physiological; Plasma; Population; Population Research; Public Health; Recommendation; Recruitment Activity; Regulation; Research; Research Design; Risk; Risk Factors; Role; Sampling; Serum; Seychelles; Site; Skin; South Africa; Study models; Sun Exposure; Supplementation; System; Testing; Time; United States National Institutes of Health; Variant; Vitamin D; Vitamin D Deficiency; Water; Weight Gain; adiponectin; bone; bone health; cardiovascular disorder risk; cohort; energy balance; follow-up; gene environment interaction; high risk; interest; mortality; novel; obesity risk; trait; urinary

DESCRIPTION (provided by applicant): The availability of data on plasma vitamin D (25(OH)D) concentrations in the last two rounds of the National Health and Nutrition Examination Survey has generated a high level of interest in the consequences of 25(OH)D deficiency and in particular its potential impact on black Americans. Fundamental new questions about the biology of vitamin D have now come to the fore. Are low 25(OH)D-intact parathyroid hormone (iPTH) levels a physiologic "abnormality" in African Americans or does the 25(OH)D-iPTH system have sufficient plasticity to adapt to low sunlight exposure? Could the low 25(OH)D levels which result from the "gene- environment discordance" observed in dark skinned populations in the US be a risk factor for metabolic disorders? Ultimately, the public health community and regulatory bodies must offer recommendations for optimal levels and supplementation. We propose to utilize cohorts from an ongoing NIH-funded study designed to identify determinants of weight change and cardiovascular disease risk in five Afro-origin populations [Modeling the Epidemiologic Transition Study (METS)] to examine these questions. The five METS countries include Ghana, Seychelles, South Africa, Jamaica and the US; the five populations differ greatly in terms of sun exposure and dietary intakes. In addition to the extensive energy expenditure, dietary intake and obesity-related metabolic markers being measured in METS, we propose to assess plasma 25(OH)D, iPTH, serum and urinary calcium, as well as bone mineral density and body composition using dual x-ray absorptiometry. The associations of adiposity, weight change, CVD risk factors such as blood pressure and insulin, and bone mineral density with 25(OH)D and iPTH will be assessed. The proposed study will provide a comprehensive assessment of the distribution and determinants of 25(OH)D-iPTH and related physiologic measures across a wide range of latitude and lifestyles. These data should contribute substantially to our understanding of the "normal" range within which these hormones function and their significance in Afro-origin populations.

描述（由申请人提供）：在国家健康和营养检查调查的最后两轮中，有关血浆维生素D（25（OH）d）浓度的数据的可用性引起了人们对25（OH）D缺乏症的后果，特别是对黑人美国人的潜在影响。关于维生素D生物学的基本新问题现在已经浮出水面。低25（OH）D-Intact甲状旁腺激素（IPTH）水平是非洲裔美国人的生理“异常”，还是25（OH）D-IPTH系统具有足够的可塑性来适应低阳光暴露？在美国深色皮肤人群中观察到的“基因环境不一致”导致的低25（OH）D水平是否是代谢疾病的危险因素？最终，公共卫生社区和监管机构必须为最佳水平和补充提供建议。我们建议从正在进行的NIH资助的研究中利用人群，旨在识别五个非洲农产品群体的体重变化和心血管疾病风险的决定因素[模拟流行病学过渡研究（METS）]来检查这些问题。五个大都会国家包括加纳，塞舌尔，南非，牙买加和美国；在暴露和饮食摄入量方面，五个人群差异很大。除了广泛的能量消耗外，我们还建议在Mets中测量饮食摄入和与肥胖相关的代谢标志物，我们建议使用双X射线吸收仪评估血浆25（OH）D，IPTH，血清和尿钙以及骨矿物质密度和身体组成。将评估肥胖，体重变化，CVD风险因素（例如血压和胰岛素）以及骨矿物质密度与25（OH）D和IPTH的关联。拟议的研究将对各种纬度和生活方式的25（OH）D-ipth及相关生理测量的分布和决定因素进行全面评估。这些数据应大大促进我们对这些激素发挥作用及其在非洲产物种群中的重要性的“正常”范围的理解。