MCSP TORFP NO. NIH-NINDS-21-01: FLORIO (ANAGIN) - BASE EC (STROKE)

MCSP TORFP 编号

• 批准号: 10881610
• 负责人: MELISSA ALLARD
• 金额: $ 147.64万
• 依托单位: ALBANY MOLECULAR RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-26 至 2024-12-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10881610
• 关键词: Area; Biological Assay; Chemistry; Computer Assisted; Contractor; Drug Compounding; Enzymes; Excretory function; In Vitro; Ischemic Stroke; Logistics; Metabolism; National Institute of Neurological Disorders and Stroke; Parents; Performance; Performance at work; Pharmaceutical Chemistry; Phase; Services; Shipping; Stroke; Structure-Activity Relationship; Toxicology; United States National Institutes of Health; absorption; base; computational chemistry; design; drug discovery; inhibitor; novel; novel therapeutics; pre-clinical; programs; small molecule; therapeutically effective

The Contractor, in performance of work under this task order shall provide a full-service facility and staff who would support a medicinal chemistry discovery program beginning at the Exploratory Chemistry phase to develop structure activity relationship (SAR) analysis and design, synthesis, in vitro absorption, distribution, metabolism, excretion and toxicology (ADMET), computational chemistry/Computer Aided Drug Discovery (CADD) and compound logistics of storage and shipping to support the Contributor Florio (Anagin) to develop a novel therapeutic effective in stroke. This will be achieved by advancing the SAR/SPR of their small molecule heterocyclic starting compound utilizing their assays and in vitro ADMET to identify novel, selective inhibitors of the target enzyme that are directed at ischemic stroke. The scope of this Medicinal Chemistry Support Program (MCSP) task order shall be medicinal chemistry services under Performance Area 2: Medicinal Chemistry Support in support of preclinical drug discovery efforts supported by NIH, NINDS and its Contributors (as outlined in the Parent SOW).

承包商在履行本规定下的工作时 任务单应提供支持药物化学的全方位服务设施和工作人员 发现计划从探索化学阶段开始，以开发结构活动 关系（SAR）分析与设计、合成、体外吸收、分布、代谢、 排泄和毒理学 (ADMET)、计算化学/计算机辅助药物发现 (CADD) 以及存储和运输的复合物流，以支持贡献者 Florio （Anagin）开发一种有效治疗中风的新型疗法。这将通过推进来实现 利用他们的分析方法获得小分子杂环起始化合物的 SAR/SPR 体外 ADMET 来鉴定针对目标酶的新型选择性抑制剂 缺血性中风。本药物化学支持计划 (MCSP) 任务单的范围 应为绩效领域 2 下的药物化学服务：药物化学支持 支持 NIH、NINDS 及其贡献者支持的临床前药物发现工作 （如父级 SOW 中所述）。