Research Training in Translational Developmental Neuroscience

转化发展神经科学研究培训

• 批准号: 8718578
• 负责人: FRANCISCO XAVIER CASTELLANOS
• 金额: $ 5.92万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-11 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8718578
• 关键词: Development; Neurosciences; Research Training

DESCRIPTION (provided by applicant): This is a revised application for a renewed Institutional National Research Service Award to support two- and three-year postdoctoral and one-year predoctoral Traineeships in Translational Developmental Neuroscience Research at the New York University Department of Child & Adolescent Psychiatry, aka Child Study Center (CSC) and the Nathan Kline Institute for Psychiatric Research (NKI) which have been configured for this express purpose. The new field of Translational Developmental Neuroscience will facilitate the integration of a wide range of disciplines to alleviate the lifelong burden of mental illness by focusing on the early developmental stages. Predoctoral trainees will be medical students who choose to extend their education by one year to conduct mentored Translational Developmental Neuroscience research working directly with the Program Director or the Co-Director in their labs. Post-doctoral trainees will be drawn from Child and Adolescent Psychiatry, Child Psychology, Pediatric Neurology, Developmental and Behavioral Pediatrics, Cognitive Neuroscience, Medical Physics, Systems Neuroscience, Neurophysiology, Applied Mathematics, and Computer Science. Available resources include expertise in pharmacological and psychosocial intervention and prevention trials, functional, structural and chemical neuroimaging, longitudinal studies, assessment of child/adolescent psychopathology, and affiliated faculties with expertise that extends from neurophysiology, basic developmental neuroscience to applied mathematics, biostatistics, biomedical engineering and biomedical physics. Research fellows work closely with two primary co-mentors to facilitate the development of independent translational research careers that will extend from the bench-to-bedside or from bedside-to-community. Trainees benefit from highly diverse patient populations at Bellevue Hospital Center, CSC, and the Rockland Children's Psychiatric Center. The overall goals of the program will continue to be to provide excellent research training focused on child mental health problems, and to advance trainees to productive academic research careers in the new discipline of Translational Developmental Neuroscience. RELEVANCE: Medicine is advancing rapidly in many areas, but the science of the brain continues to lag behind, especially when addressing the emotional and behavioral problems of children and adolescents. We propose to train a new type of scientist who will bring a wealth of perspectives to these important challenges by providing individualized mentoring to junior scientists who have completed their doctoral and clinical studies.

描述（由申请人提供）：这是更新的机构国家研究服务奖的修订申请，以支持纽约大学儿童和青少年系的转化发展神经科学研究的两年和三年博士后和一年博士前培训精神病学，又称儿童研究中心 (CSC) 和内森·克莱恩精神病学研究所 (NKI) 就是为此目的而配置的。转化发展神经科学的新领域将促进广泛学科的整合，通过关注早期发展阶段来减轻精神疾病的终生负担。博士前培训生将是医学生，他们选择将教育延长一年，直接与实验室的项目主任或联合主任一起进行指导性转化发展神经科学研究。博士后学员将来自儿童和青少年精神病学、儿童心理学、小儿神经病学、发育和行为儿科、认知神经科学、医学物理学、系统神经科学、神经生理学、应用数学和计算机科学。可用资源包括药理学和心理社会干预和预防试验、功能、结构和化学神经影像、纵向研究、儿童/青少年精神病理学评估方面的专业知识，以及具有从神经生理学、基础发育神经科学到应用数学、生物统计学、生物医学专业知识的附属院系。工程和生物医学物理学。研究人员与两位主要共同导师密切合作，促进独立转化研究职业的发展，从实验室延伸到临床，或从临床延伸到社区。贝尔维尤医院中心、CSC 和罗克兰儿童精神病中心高度多样化的患者群体让学员受益匪浅。该计划的总体目标将继续是提供专注于儿童心理健康问题的优秀研究培训，并推动学员在转化发展神经科学这一新学科中取得富有成效的学术研究生涯。相关性：医学在许多领域都在迅速发展，但大脑科学仍然落后，特别是在解决儿童和青少年的情绪和行为问题时。我们建议培养新型科学家，通过为完成博士和临床研究的初级科学家提供个性化指导，为这些重要挑战带来丰富的视角。

项目成果

Critical periods revisited: implications for intervention with traumatized children.

• DOI: 10.1016/j.jaac.2011.07.021
• 发表时间: 2011-11
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Weder N;Kaufman J
• 通讯作者: Kaufman J

Mode of Anisotropy Reveals Global Diffusion Alterations in Attention-Deficit/Hyperactivity Disorder.

• DOI: 10.1016/j.jaac.2015.11.011
• 发表时间: 2016-02
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Yoncheva YN;Somandepalli K;Reiss PT;Kelly C;Di Martino A;Lazar M;Zhou J;Milham MP;Castellanos FX
• 通讯作者: Castellanos FX

[Functional cerebral activity in a state of rest: connectivity networks].

[休息状态下的功能性大脑活动：连接网络]。

• 发表时间: 2011
• 期刊: Revista de neurologia
• 影响因子: 1.2
• 作者: Proal,Erika;Alvarez-Segura,Mar;delaIglesia-Vayá,María;Martí-Bonmatí,Luis;Castellanos,FXavier;SpanishRestingStateNetwork
• 通讯作者: SpanishRestingStateNetwork

Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of 'high definition' neuroimaging.

• DOI: 10.1016/j.conb.2014.08.005
• 发表时间: 2015-02
• 期刊: Current opinion in neurobiology
• 影响因子: 5.7
• 作者: Baroni A;Castellanos FX
• 通讯作者: Castellanos FX

Computerized cognitive training for children with neurofibromatosis type 1: A pilot resting-state fMRI study.

• DOI: 10.1016/j.pscychresns.2017.06.003
• 发表时间: 2017-08-30
• 期刊: Psychiatry research. Neuroimaging
• 作者: Yoncheva YN;Hardy KK;Lurie DJ;Somandepalli K;Yang L;Vezina G;Kadom N;Packer RJ;Milham MP;Castellanos FX;Acosta MT
• 通讯作者: Acosta MT