Developmental Functions of the MNS: Social anticipation and imitation

MNS 的发育功能：社会预期和模仿

• 批准号: 8473236
• 负责人: AMANDA L WOODWARD
• 金额: $ 30.63万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8473236
• 关键词: Address; Adult; Autistic Disorder; Behavioral; Child; Code; Cognitive; Computer Simulation; Data; Development; Developmental Process; Disease; Educational process of instructing; Electroencephalogram; Eye; Functional disorder; Generations; Goals; Human; Individual; Infant; Infant Development; Investigation; Laboratories; Lead; Left; Life; Light; Link; Measures; Methods; Motor; Movement; Outcome; Pattern; Perception; Primates; Process; Production; Property; Recruitment Activity; Research; Role; Shapes; Social Functioning; Social Perception; Specific qualifier value; Structure; Support System; System; Testing; Training; behavior measurement; contextual factors; developmental disease; experience; infancy; information processing; insight; mirror neuron; mirror neuron system; neural patterning; neurophysiology; relating to nervous system; research study; response; social

Converging evidence from across laboratories and approaches has documented the existence of shared neural representations for the perception and production of action (termed mirror neurons or the mirror neuron system, MNS) in adult nonhuman and human primates. Although it is widely hypothesized that the MNS supports the development of social perception and social responses, there is little direct investigation of these possibilities. The proposed experiments address this issue by investigating the potential role of the MNS in the development of two foundational social abilities: action anticipation, the ability to generate predictions about the outcomes of others' actions, and goal imitation, the ability to reproduce the meaningful components of others' actions. The first goal of the proposed research is to use behavioral methods to test the hypothesis that developing action production systems support infants' abilities to anticipate and imitate others' actions. To this end. Panel 1 develops eye-tracking measures of action anticipation and Panel 2 develops behavioral measures of goal imitation. Each panel will investigate relations between the focal ability and infants' own developing actions, as well as the effects of motor training and motor interference. In addition, drawing on insights from Project III, these studies will test whether infants' anticipatory and imitative responses are modulated by the contextual factors that modulate mirror neuron function in primates. The second goal of the proposed research is to implement these measures in studies that assess the neural processes that correlate with infants' action anticipation and goal imitation. The studies in Panel 3 pursue this goal by integrating the behavioral measures developed in Panels 1 and 2 with electroencephalogram (EEG) studies of mu rhythm suppression, a neural response that has been argued to reflect MNS activation. To achieve this goal, the studies will draw on methods developed in Projects I and IV. In addition to addressing these two primary research goals, the data from these experiments will be recruited to inform the development of computational models in Project IV.

跨实验室和方法的融合证据已经证明了共享的存在 动作感知和产生的神经表示（称为镜像神经元或镜像 成人非人类和人类灵长类动物的神经元系统，MNS）。尽管广泛假设 MNS支持社会观念和社会反应的发展，几乎没有直接调查 这些可能性。提出的实验通过研究 MN在发展两个基础社会能力的发展中：行动期望，产生的能力 关于他人行动和目标模仿结果的预测，重现有意义的能力 他人行为的组成部分。 拟议研究的第一个目标是使用行为方法来检验以下假设。 开发行动生产系统支持婴儿预测和模仿他人行动的能力。为此。面板1开发了动作预期的眼神追踪测度，面板2制定了目标模仿的行为度量。每个面板将研究焦点能力与婴儿自己发育的动作之间的关系，以及运动训练和运动干扰的影响。此外，利用项目III的见解，这些研究将测试婴儿的预期和模仿反应是否受到调节灵长类动物镜像神经元功能的上下文因素的调节。 拟议的研究的第二个目标是在评估与婴儿的行动预期和目标模仿相关的神经过程的研究中实施这些措施。面板3中的研究通过将面板1和2中制定的行为措施与 脑电图抑制的脑电图（EEG）研究，这是一种神经反应，被认为反映了MNS激活。为了实现这一目标，研究将利用项目I和IV中开发的方法。 除了解决这两个主要研究目标外，这些实验的数据还将 招募以告知项目IV中计算模型的开发。