Safe PASSage Study Administrative Supplement - Effects of Overnight Maternal Slee

Safe PASSage 研究行政补充 - 产妇过夜睡眠的影响

• 批准号: 8705803
• 负责人: Kimberly A. Dukes
• 金额: $ 2.71万
• 依托单位: DM-STAT, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8705803
• 关键词: Abbreviations; Administrative Supplement; Affect; Alcohol consumption; Alcohols; Anxiety; Autopsy; Biological Neural Networks; Brain; Brain Stem; Cerebral cortex; Child; Child health care; Clinical; Cognitive; Collaborations; Collection; Communication; Communities; Community Networks; Complex; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Quality; Development; Electroencephalography; Enrollment; Environmental Risk Factor; Epidemiology; Face; Failure; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Death; Fetal Development; Fetal Growth; Fetal Mortality Statistics; Fetal Ultrasonography; Fetus; Forensic Medicine; Functional disorder; Funding; Goals; Governing Board; Growth; Hearing; Infant; Infant Development; Infant Mortality; Investigation; Knowledge; Leadership; Life; Link; Maternal Age; Measures; Mediating; Medical; Mental Depression; Mission; National Institute of Child Health and Human Development; National Institute on Alcohol Abuse and Alcoholism; National Institute on Deafness and Other Communication Disorders; Neurotransmitters; Outcome; Participant; Pathologic; Pathology; Pattern; Performance; Perfusion; Perinatal; Phase; Physiological; Placenta; Population; Pregnancy; Pregnancy Outcome; Pregnant Women; Principal Investigator; Prospective Studies; Public Health; Reporting; Request for Applications; Research; Research Infrastructure; Research Personnel; Risk; Role; Site; Stress; Structure; Sudden infant death syndrome; Synapses; Time; Ultrasonography; Variant; Work; adverse outcome; aging nutrition; base; cost effective; critical period; data management; fetal; fetal tobacco exposure; follow-up; high risk; improved; in vivo; indexing; infant death; interest; member; neurobehavioral; postnatal; prenatal; prevent; programs; protocol development; resilience; response; stillbirth; tobacco exposure

DESCRIPTION (provided by applicant): In 2006, the NICHD/NIAAA/NIDCD-funded PASS Network (Phase 11) initiated the planned enrollment of approximately 12,000 pregnant women from high-risk populations for prenatal alcohol exposure, SIDS, stillbirth, and FASD in a prospective study with follow-up of their infants to one postnatal year ( the time- frame for SIDS). This application is in response to RFA-HD-10-018 to complete enrollment and follow-up with study participants, oversee data collection, data cleaning and management, and conduct statistical analysis. This particular application pertains to the Data Coordinating and Analysis Center (DCAC) of the PASS Network. The long-term goals of the Safe Passage Study are to decrease fetal and infant mortality and improve child health in communities at high risk for prenatal maternal alcohol consumption. The primary hypothesis of the PASS Network is that prenatal alcohol exposure increases the risk for SIDS and stillbirth. Secondary hypotheses examine the role of interactions between prenatal alcohol exposure and other maternal and environmental factors upon the function and structure of the placenta, development of the fetal and infant face, autonomic function, hearing, and cortical activity in the fetus and/or infant, fetal growth and in vivo brain development with ultrasonography, and neurotransmitter and synaptic maturation in the brainstem and cerebral cortex in autopsy studies of the fetus and infant. The ability of the PASS Network to provide accurate and valid evidence of potential associations between prenatal alcohol exposure and adverse perinatal outcomes depends on extensive collaboration among the Network investigators and the collection and analysis of high quality data, all of which is facilitated by the DCAC. The mission of the DCAC is to work collaboratively with the investigators of the PASS Network and communities to: (1) Develop and maintain a network-wide infrastructure as a vehicle for communication and information exchange for the promotion of collaboration within the PASS Network and for the provision of logistical and administrative support to all members of the Network; (2) Provide biostatistical and epidemiological expertise to the PASS Network; (3) Provide leadership in protocol development and implementation for the PASS Network; (4) Provide centralized, efficient, cost-effective and quality data management to the PASS Network; and (5) To support the needs of the Network governing boards.

描述（由申请人提供）：2006年，NICHD/NIAAA/NIDCD资助的Pass网络（第11阶段）在高风险人群中启动了大约12,000名孕妇在高风险人群中进行产前酒精，SIDS，SID，Stilts，Stiltbirth和FASD的预期研究，并在一项前瞻性研究中进行了对婴儿的跟进，以进行幼体，以适用于幼体的年度（sive to one Persnatal Yearnatal年）。此应用是对RFA-HD-10-018的响应，以完成研究参与者的入学和跟进，监督数据收集，数据清洁和管理以及进行统计分析。该特定的应用程序与PASS网络的数据协调和分析中心（DCAC）有关。安全通道研究的长期目标是降低胎儿和婴儿死亡率，并改善产前孕妇饮酒风险高风险的社区的儿童健康。通过网络的主要假设是，产前酒精暴露会增加小岛屿发展中国家和死产的风险。 Secondary hypotheses examine the role of interactions between prenatal alcohol exposure and other maternal and environmental factors upon the function and structure of the placenta, development of the fetal and infant face, autonomic function, hearing, and cortical activity in the fetus and/or infant, fetal growth and in vivo brain development with ultrasonography, and neurotransmitter and synaptic maturation in the brainstem and cerebral cortex in autopsy胎儿和婴儿的研究。通过网络提供准确有效的证据证明产前酒精暴露与不良围产期结果之间潜在关联的能力取决于网络研究者之间的广泛协作以及对高质量数据的收集和分析，所有这些数据都由DCAC促进。 DCAC的使命是与通过网络和社区的调查人员合作：（1）开发和维护范围内的网络基础架构，作为通信和信息交流的工具，以促进通行网络中的协作以及向所有网络成员提供后勤和行政支持； （2）为通过网络提供生物统计学和流行病学专业知识； （3）在通行网络中提供协议开发和实施的领导； （4）为通过网络提供集中，高效，成本效益和质量数据管理； （5）支持网络管理委员会的需求。