Research Training in Sensorimotor Neurorehabilitation

感觉运动神经康复研究培训

• 批准号: 10836628
• 负责人: Charles Heckman
• 金额: $ 5.33万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10836628
• 关键词: Research Training; neurological rehabilitation

Project Summary The goal of this proposal is to implement a novel Research Training in Sensorimotor Neurorehabilitation program to prepare the next generation of scientists that can address the growing need for neuroscience- based rehabilitation solutions. Northwestern University has a long and recognized history in the study of motor control, motor disability and recovery, and neural reorganization; and in training the next generation of movement and rehabilitation scientists (MRS) through the Northwestern University Interdepartmental Neuroscience Program (NUIN) PhD program since 2009, with demonstrated success reflected in more than 20 graduates currently leading successful research careers in academia and industry. The proposed program is built on this research and training record with the mission to train students with clinical and life/applied science backgrounds and post-doctoral fellows with clinical backgrounds to become rehabilitation scientists in basic, translational or clinical research. These scientists will have the ability to integrate knowledge from the various disciplines involved in sensorimotor neurorehabilitation, including neuroscience, engineering and clinical sciences. The training program will focus on four training goals: 1) to provide a thorough grounding in the basic neurobiology of sensorimotor function and control, including translation of insights between animal and human research models; 2) to learn fundamental engineering experimental methods for measurement and analysis of neuronal and musculoskeletal sensory and motor function; 3) to facilitate knowledge sharing in the clinical management of individuals with movement disorders between the post-doctoral and pre-doctoral trainees; and 4) to provide professional development training to support future rehabilitation research career success. The unique structure of the program, couples training of post-doctoral trainees with clinical expertise with pre-doctoral trainees focusing on neuroscience. The program is the first of its kind to provide post-doctoral research training of Doctors of Physical Therapy (DPT), an untapped cohort of prospective scientists that has emerged in the contemporary age of science-based medicine and evidence-based practice. These DPT candidates for post-doctoral slots will be drawn from research intensive Physical Therapy Programs across the United States. Pre-doctoral trainees will be drawn from the NUIN-MRS program. The translational interdisciplinary nature of the program will allow close interaction between clinical investigators and basic and applied sciences investigators, providing a unique opportunity for training in translational research. We intend to support a total of 12 pre-doctoral trainees and 5 post-doctoral trainees with NIH funding for up to two years each. Additional institutional support is available in the form of tuition and stipend supplements for trainees and diversity fellowships to support diversity recruiting efforts.

项目概要 该提案的目标是实施一种新颖的感觉运动神经康复研究培训 该计划旨在培养下一代科学家，以满足神经科学日益增长的需求 基于的康复解决方案。西北大学在电机研究方面拥有悠久且公认的历史 控制、运动障碍和恢复以及神经重组；并在培训下一代 西北大学跨部门的运动和康复科学家（MRS） 自 2009 年以来，神经科学项目 (NUIN) 博士项目已取得了超过 20 名毕业生目前在学术界和工业界领导着成功的研究事业。拟议的计划 建立在这项研究和培训记录的基础上，其使命是培养学生的临床和生活/应用能力 科学背景和具有临床背景的博士后研究员成为康复科学家 基础、转化或临床研究。这些科学家将有能力整合来自各个领域的知识 涉及感觉运动神经康复的各个学科，包括神经科学、工程学和 临床科学。培训计划将重点关注四个培训目标： 1) 提供全面的基础知识 感觉运动功能和控制的基本神经生物学，包括动物之间见解的翻译 和人类研究模型； 2）学习基本的工程测量实验方法 神经元和肌肉骨骼感觉和运动功能的分析； 3）促进知识共享 博士后和博士前期间运动障碍患者的临床管理 实习生； 4）提供专业发展培训以支持未来的康复研究事业 成功。项目结构独特，结合临床专业知识培养博士后学员 与专注于神经科学的博士前学员。该项目是同类项目中第一个提供博士后的项目 物理治疗博士（DPT）的研究培训，这是一群尚未开发的未来科学家， 出现在当代以科学为基础的医学和循证实践的时代。这些DPT 博士后职位的候选人将从研究密集型物理治疗项目中抽取 美国。博士前培训生将从 NUIN-MRS 项目中选拔。翻译的 该计划的跨学科性质将允许临床研究人员和基础研究人员之间密切互动 应用科学研究人员，为转化研究培训提供了独特的机会。我们打算 利用 NIH 资助总共 12 名博士前培训生和 5 名博士后培训生，为期两年 每个。额外的机构支持以学费和津贴补贴的形式提供给受训者和 多元化奖学金支持多元化招聘工作。

项目成果

Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery.

结合高剂量治疗、双侧运动启动和迷走神经刺激来治疗慢性中风幸存者的偏瘫上肢：促进康复的视角。

• 发表时间: 2023
• 作者: King, Erin C;Pedi, Elizabeth;Stoykov, Mary Ellen;Corcos, Daniel M;Urday, Sebastian
• 通讯作者: Urday, Sebastian

Seeing does not mean processing: where we look and the visual information we rely on change independently as we learn a novel walking task.

观看并不意味着处理：当我们学习新的步行任务时，我们看的地方和我们依赖的视觉信息会独立变化。

• 发表时间: 2023-10
• 影响因子: 2
• 作者: Cates, Alexander;Gordon, Keith E
• 通讯作者: Gordon, Keith E

Estimates of persistent inward currents in lower limb motoneurons are larger in females than in males.

女性下肢运动神经元持续内向电流的估计值大于男性。

• 发表时间: 2023-06-01
• 影响因子: 2.5
• 作者: Jenz, Sophia T;Beauchamp, James A;Gomes, Matheus M;Negro, Francesco;Heckman, C J;Pearcey, Gregory E P
• 通讯作者: Pearcey, Gregory E P