DEVELOPMENTAL FUNDS

发展基金

• 批准号: 8375753
• 负责人: Riccardo Dalla-Favera
• 金额: $ 31.8万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8375753
• 关键词: Adult; Affect; Appointment; Area; Award; Basic Science; Biology; Brain Neoplasms; Breast Carcinoma; Cancer Center Support Grant; Categories; Cell Cycle; Cell Cycle Regulation; Cells; Cellular biology; Chromosomes; Clinical; Committee Members; Coupled; Couples; Cutaneous; Data; Dermatology; Development; Disease; Doctor of Philosophy; Ensure; Esthesia; Fostering; Foundations; Funding; Funding Mechanisms; Funding Opportunities; Genome; Glioma; Goals; Grant; Helix-Turn-Helix Motifs; Howard Temin Award; Human; Id2 protein; Incidence; Judgment; Knowledge; Leadership; Lymphoblastic Leukemia; Malignant Neoplasms; Malignant neoplasm of brain; Mammary gland; Manuscripts; Memory; Metaphase; Mitosis; Molecular; Motor Skills; Mus; Mutagenesis; Nature; Neoplasms; Neurobiology; Neurology; Oncogenic; Outcome; Pathway interactions; Patients; Personality; Philanthropic Fund; Pilot Projects; Population Sciences; Preparation; Primary Brain Neoplasms; Research; Science; Speech; Staging; Stem cells; Study Section; System; T-Lymphocyte; Technology; Time; Translating; Translational Research; Tumor Angiogenesis; Tumor Biology; Tumor Suppressor Proteins; United States; United States National Institutes of Health; Universities; Work; anaphase-promoting complex; axon growth; base; cancer stem cell; cost; demethylation; disease classification; malignant phenotype; member; neoplastic cell; neuro-oncology; neurosurgery; novel; novel therapeutics; oncology program; programs; response; therapeutic target; transcription factor; tumor

DEVELOPMENTAL FUNDS Developmental funds, $470,000, are requested to support HICCC pilot project initiatives that foster translational research, ($320,000) and cancer projects of outstanding merit that were rated above the 20th percentile by an NIH study section ($150,000). These Center initiatives were implemented by the SLT in 2007. Over the past funding period CCSG Development funds were limited to $147,806 per year due to budgetary constraints following the last competition. Following the appointment of the Center Director in March 2005, it was decided that funds in this category would not be awarded until the Center's research programs were reorganized and Center membership reviewed and approved. At the time of this submission, the accumulated total, $591,224, has been carried over to the no-cost extension period, July 2007 - June 2008, to be used in support of program-specific pilot projects. To promote novel research initiatives through the pilot project mechanism during the current project period, HICCC utilized philanthropic funds totaling $1.7M to fund 31 current or former HICCC members. Annual project funding was $35,000 to $50,000 for one to two years. Richard Baer, PhD, Associate Director for Basic Research, oversees the Center's pilot project initiatives. He is responsible for organizing and selecting the ad hoc committee members based on the subject matter of the funding opportunity and ensuring rigorous scientific review using the NIH scoring system. Selected pilot projects supported by philanthropic funds during the project period include: ¿ Characterization of the tumor suppressor ARC in mitosis, Y. Mao (CGE) Outcome: Zhang, J., Ahmad, S., Mao, Y., (2007) BubRland APC/EB1 cooperate to maintain metaphase chromosome alignment. J Cell Biol 178: 773-784. ¿ Mechanisms and consequences of genome demethylation in mammary carcinoma, T. Bestor (CGE) Outcome: NIH R01 grant based on pilot data in planning stages. ¿ Stem cells and cancer stem cells in mouse mammary glands, A Efstratiadis (BC) Outcome: Preliminary data was the basis for a May 2007 "Work Study" under the same title between Columbia Science & Technology Ventures and Merck. ¿ Dissecting oncogenic pathways in T-ALL: retroviral mutagenesis and human T-cell lymphoblastic leukemia, A Ferrando (LDM) Outcome: two manuscripts in preparation ¿ Helix loop helix transcription factors in differentiation and proliferation of tumor cells, A lavarone (CSN) Outcome: NIH/NCI R01CA85628 Id2 in cell cycle regulation and cancer $230,000/year, 8/1/2006- 7/31/2011 ¿ Stem cells and the genesis of epidermal tumors, D Owens (CGE) Outcome: Dermatology Foundation grant, Epiderma stem cells as targets for cutaneous neoplasia $55,000/year, 7/1/2006-6/30/2007 ¿ Id2 protein in glioma tumor angiogenesis, A Lasorella (CSN) Outcome: Lasorella A., Stegmuller J., Guardavaccaro D., Liu G., Carro M.S., Rothschild G., de la Torre- Ubieta L., Pagano M., Bonni A., lavarone A., Degradation of Id2 by the anaphase promoting complex couples cell cycle exit and axonal growth. Nature, 422:471-474, 2006 Other HICCC members who received pilot project funds during the project period include: R. Baer, K. Crew J. Gautier, D Hershman, and K Joseph, (BC); A Joe and I B Weinstein, (PCD); and MB Terry and T Liu (CE), W. Gu (CSN and BC), and J Kandel (PC). In 2007, the HICCC's senior leadership team agreed on the following funding mechanisms to promote intraand inter-programmatic translational research: HICCC Program-specific Pilot (PROspe) Fund to stimulate intra-programmatic translational research initiatives. Each of the seven research programs and the developing Neuro-oncology program are assigned $70,000 to fund, on a competitive basis, a pilot project of strategic relevance to the translational goals of the program. Funding opportunities have been announced and awardees will be selected by mid October. ¿ HICCC Inter-programmatic (InterPro) Pilot Project Fund to stimulate inter-programmatic translational research initiatives. The HICCC will assign to each program $40,000 to fund, on a competitive basis, a pilot project that involves Pis from two programs, with priority given to those projects involving programs from two distinct areas, i.e., basic, disease-specific, or population science. Institutional and philanthropic funds will support the HICCC inter-programmatic pilot project initiative. Funding opportunities have been announced and awardees will be selected by mid-October ¿ In the summer of 2007, the HICCC initiated the Bridging Award (BrAwa) to support cancer projects of outstanding merit that were rated above the 20th percentile by an NIH study section as a first application or competitive renewal but were not funded due to budgetary restrictions. The HICCC Bridging Award will fund annually, on a competitive basis, two $75,000 projects. Notices of this funding opportunity have been announced and funding will be awarded in December 2007.

发展基金 开发基金（470,000美元）被要求支持HICCC飞行员项目倡议 转化研究（32万美元）和杰出功绩的癌症项目被评为第20位以上 NIH研究部分（150,000美元）。这些中心计划由SLT于2007年实施。 在过去的资金期间，由于预算，CCSG开发基金每年限制为147,806美元 最后一场比赛之后的约束。在2005年3月任命中心主任之后， 被认为，直到中心的研究计划是 重组和中心会员资格审查和批准。在此提交时，累积 总计591,224美元，已延长到2007年7月至2008年6月的无成本延长期 支持特定计划的试点项目。 在当前项目期间通过试点项目机制促进新颖的研究计划， HICCC利用了总计170万美元的慈善资金来资助31名现任或前HICCC成员。年度项目 一到两年的资金为35,000至50,000美元。理查德·贝尔（Richard Baer）博士，基本副总监 研究，监督该中心的试点项目计划。他负责组织和选择广告 HOC委员会成员基于资金机会的主题并确保严格 使用NIH评分系统的科学审查。 在项目期间，慈善基金支持的选定试点项目包括： »肿瘤抑制弧的特征在有丝分裂中，Y. Mao（CGE） 结果：Zhang，J.，Ahmad，S.，Mao，Y。 染色体对齐。 J Cell Biol 178：773-784。 �乳腺癌中基因组去甲基化的机制和后果，T。Bestor（CGE） 结果：基于计划阶段的试点数据的NIH R01赠款。 „小鼠乳腺中的干细胞和癌症干细胞，Efstratiadis（BC） 结果：初步数据是2007年5月“工作研究”的基础 哥伦比亚科学技术风险投资与默克。 »在T-ALL中解剖致癌途径：逆转录病毒诱变和人类T细胞淋巴细胞白血病， Ferrando（LDM） 结果：准备两个手稿 »肿瘤细胞分化和增殖中的螺旋环螺旋转录因子，lavarone（CSN） 结果：细胞周期和癌症中的NIH/NCI R01CA85628 ID2 $ 230,000/年，8/1/2006-- 2011年7月31日 »干细胞和表皮肿瘤的起源，D Owens（CGE） 结果：皮肤科基金会赠款，表皮干细胞作为皮肤肿瘤的靶标 $ 55,000/年，7/1/2006-6/30/2007 �胶质瘤肿瘤血管生成中的ID2蛋白，Lasorella（CSN） 结果：Lasorella A.，Stegmuller J.，Guardavaccaro D.，Liu G.，Carro M.S.，Rothschild G.，de la Torre- Ubieta L.，Pagano M.，Bonni A.，Lavarone A. 夫妻细胞周期出口和轴突生长。自然，422：471-474，2006 在该项目期间收到试点项目资金的其他HICCC成员包括： R. Baer，K。 Crew J. Gautier，D Hershman和K Joseph（BC）；乔和我B温斯坦（PCD）；和MB Terry 和T Liu（CE），W。Gu（CSN和BC）和J Kandel（PC）。 2007年，HICCC的高级领导团队达成了以下资金机制，以促进内部 典型的翻译研究： HICCC计划特定的飞行员（PROSPE）基金刺激了临时翻译研究 倡议。分配了七个研究计划和发展中的神经肿瘤计划 $ 70,000以竞争性资金，是一个与战略相关性的试点项目 该程序。已经宣布了资金机会，并将在10月中旬之前选出获奖者。 »HICCC跨编程（Interpro）试点项目基金以刺激程序间翻译 研究计划。 HICCC将分配每个计划的40,000美元，以竞争性为基础 涉及两个程序的PI的项目，优先考虑那些涉及计划的项目 两个不同的领域，即基本，特定疾病或人口科学。机构和慈善资金 将支持HICCC程序间试点项目计划。资金机会已经 宣布，获奖者将于10月中旬选出 HICCC在2007年夏天启动了桥接奖（BRAWA），以支持 NIH研究部分将其评为第20个百分点的杰出功绩作为第一个申请或 竞争性更新，但由于预算限制而未资助。 HICCC桥接奖将 每年在竞争性的基础上进行资金，这是两个$ 75,000的项目。这个资金机会的通知已经 宣布和资金将于2007年12月授予。