Molecular Transducers of Physical Activity Consortium (MoTrPAC): Pediatric Clinical Center

体力活动分子传感器联盟 (MoTrPAC)：儿科临床中心

基本信息

批准号：
10841339
负责人：
DAN M COOPER
金额：
$ 141万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10841339
关键词：
17 year old 18 year old Acceleration Acute Adolescent Adult Age Age Years Ancillary Study Animals Award Bioinformatics Biological Process Blood COVID-19 pandemic Charge Chemicals Child Childhood Chronic Clinical Clinical Protocols Clinical Research Clinical Trials Data Monitoring Committees Collaborations Collection Communication Communities Data Development Disease Disease Outcome Educational Intervention Enrollment Ensure Exercise Exercise Test Frequencies Funding Gender Goals Health Health Benefit Heterogeneity Human Individual Institution Institutional Review Boards Intervention Longevity Manuals Manuscripts Maps Measurement Minority Groups Molecular Multi-site clinical study Observational Study Participant Pathway interactions Phase Phenotype Physical activity Physiological Procedures Protocols documentation Public Health Race Randomized Randomized, Controlled Trials Recruitment Activity Research Research Personnel Resistance Resources Schedule Site Suspensions Time Tissues Training Training Programs Transducers United States National Institutes of Health Visit Youth age group clinical center cohort design endurance exercise ethnic minority exercise training falls follow-up gender equality improved innovation insight multiple omics novel operation pandemic disease phenotypic data pre-clinical public database quality assurance racial minority recruit resistance exercise response sedentary sex working group

项目摘要

PROJECT SUMMARY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers that underlie the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) that are randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators and are not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex balanced and with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, MoTrPAC activities were suspended for over a year (beginning in March 2020) with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric clinical centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led to the NIH Common Fund to release the current NOFO (RFA-RM- 23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.

项目概要体力活动分子传感器联盟 (MoTrPAC) 旨在发现和表征影响人类运动效果的一系列分子传感器。 MoTrPAC 推出于 2016 年与六个成人临床中心和一个儿科中心合作生成了广泛的手册指导涉及临床操作各个方面的研究方案（第一阶段）。第二阶段于 2019 年秋季开始，所有人类临床中心在初步招募方面均取得了良好进展协议的目标和实施。 NIH 制定的最初目标是招募 270 名儿童（10-17 岁）岁）和 1980 名久坐的成年人（18 岁或以上）随机接受耐力训练（170 名青少年，840 名成人）、阻力训练（840 名成人）或非运动控制（50 名青少年，300 名成人）。一个另外一组接受过高度活跃耐力（50 名青少年、150 名成人）和阻力（150 名成人）训练的人员作为比较者，不参加 MoTrPAC 演习训练计划。招聘及招生方式性别平衡，参与者年龄各异（10-17、18-39、40-59 和 >60 岁年龄组）和不同种族。由于 COVID-19 大流行，MoTrPAC 活动受到影响暂停一年多（从 2020 年 3 月开始），并在 2022 年之前继续受到限制。由于大流行、成人和儿科的招聘活动遇到了许多挑战临床中心已加快速度，预计将成功实现目标注册人数在新的奖励期结束时。这导致 NIH 共同基金发布了当前的 NOFO (RFA-RM- 23-010）为 MoTrPAC 提供资金以完成临床研究的招募和随访，包括完成久坐的成人和儿童的机械随机对照试验以及观察性研究高度活跃的成人和儿童。这将丰富对于理解运动至关重要的参与者群体年龄、性别和少数群体之间的适应性和异质性。总而言之，此扩展将允许 MoTrPAC将按照最初设想完成预期目标，并将为公众提供更完整的信息运动对健康的益处的数据库，并提供有关身体活动如何减轻疾病的见解。